초록 ▼

This invention relates to the treatment of a patient's lung, for example, a lung exhibiting chronic obstructive pulmonary disease (COPD) and in particular to methods and devices for affecting lung volume reduction, preferably for achieving acute or immediate lung volume reduction following treatment

This invention relates to the treatment of a patient's lung, for example, a lung exhibiting chronic obstructive pulmonary disease (COPD) and in particular to methods and devices for affecting lung volume reduction, preferably for achieving acute or immediate lung volume reduction following treatment. The lung volume reduction is effected by delivering a condensable vapor at a temperature above body temperature to the desired regions of the patient's lung to damage tissue therein. Blood flow and air flow to the damaged tissue region is essentially terminated, rendering the target region non-functional. Alternative energy sources may be used to effect the thermal damage to the lung tissue.

대표청구항 ▼

1. A method of treating a patient's lung comprising: determining a predetermined volume of condensable vapor to deliver based on a diagnostic evaluation or a parameter of the patient;after the determining step, delivering the predetermined volume of condensable vapor to a sub segmental bronchi of th

1. A method of treating a patient's lung comprising: determining a predetermined volume of condensable vapor to deliver based on a diagnostic evaluation or a parameter of the patient;after the determining step, delivering the predetermined volume of condensable vapor to a sub segmental bronchi of the patient's lung, and raising the temperature of tissue in the lung to render it non-functional. 2. The method of claim 1 further comprising monitoring pressure within the sub segmental bronchi and venting the sub segmental bronchi if a pressure limit is reached. 3. The method of claim 1 further comprising monitoring temperature within the sub segmental bronchi and lavaging the sub segmental bronchi if a temperature limit is reached. 4. The method of claim 1 wherein delivering the predetermined volume of the condensable vapor to the sub segmental bronchi of the patient's lung comprises inducing neointima hyperplasia in the lung. 5. The method of claim 1 wherein delivering the predetermined volume of the condensable vapor to the sub segmental bronchi of the patient's lung comprises inducing tissue injury and necrosis leading to fibrosis. 6. The method of claim 1 wherein a vacuum is generated within the sub segmental bronchi to facilitate collapse of tissue structures thereof. 7. The method of claim 6 wherein the tissue structures collapsed are at least one of the group consisting of an air sac of the patient's sub segmental bronchi, terminal bronchioles in the sub segmental bronchi and collateral passageways in the sub segmental bronchi. 8. A method of treating a patient's lung comprising: determining a predetermined volume of condensable vapor to deliver based on a diagnostic evaluation or a parameter of the patient; andafter the determining step, delivering the predetermined volume of condensable vapor having a temperature of approximately 60 to 100 degrees C. to a targeted region of the patient's lung, and raising the temperature of tissue in the targeted region to render it non-functional. 9. The method of claim 8 further comprising monitoring pressure within the targeted region and venting the targeted region if a pressure limit is reached. 10. The method of claim 8 further comprising monitoring temperature within the targeted region and lavaging the targeting region if a temperature limit is reached. 11. The method of claim 8 wherein delivering the predetermined volume of the condensable vapor to the targeted region of the patient's lung comprises inducing neointima hyperplasia in the lung. 12. The method of claim 8 wherein delivering the predetermined volume of the condensable vapor to the targeted region of the patient's lung comprises inducing tissue injury and necrosis leading to fibrosis in the lung. 13. The method of claim 8 wherein a vacuum is generated within the targeted region to facilitate collapse of tissue structures thereof. 14. The method of claim 13 wherein the tissue structures collapsed are at least one of the group consisting of an air sac of the patient's targeted region, terminal bronchioles in the targeted region and collateral passageways in the targeted region.