Transdermal delivery of beneficial substances effected by a hostile biophysical environment
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/195
A61K-047/18
A61K-009/00
A61K-047/02
A61K-031/192
A61K-031/519
A61K-031/198
A61K-031/522
A61K-009/06
A61K-047/06
A61K-047/10
A61K-047/14
A61K-047/26
출원번호
US-0587323
(2005-04-19)
등록번호
US-9050365
(2015-06-09)
국제출원번호
PCT/US2005/013228
(2005-04-19)
§371/§102 date
20070821
(20070821)
국제공개번호
WO2005/102282
(2005-11-03)
발명자
/ 주소
Fossel, Eric Thor
출원인 / 주소
Strategic Science & Technologies, LLC
대리인 / 주소
Wolf, Greenfield & Sacks, P.C.
인용정보
피인용 횟수 :
11인용 특허 :
104
초록▼
The present invention generally relates to the transdermal delivery of substances and, in some embodiments, to the transdermal delivery of beneficial substances by a hostile biophysical environment. In one aspect, various methods for the transdermal delivery of beneficial substances are disclosed. B
The present invention generally relates to the transdermal delivery of substances and, in some embodiments, to the transdermal delivery of beneficial substances by a hostile biophysical environment. In one aspect, various methods for the transdermal delivery of beneficial substances are disclosed. By creating a hostile biophysical environment, beneficial substances may be delivered, according to certain embodiments, through the stratum corneum of the skin into the body. Beneficial substances include, but are not limited to, pharmaceutical agents, drugs, vitamins, co-factors, peptides, dietary supplements, and others. The beneficial effects disclosed include, for instance, relief of pain and inflammation, prevention and healing of ulcers of the skin, relief of headache, improved sexual function and enjoyment, growth of hair on the scalp, improving muscle size and/or function, removing body fat and/or cellulite, treating cancer, treating viral infections and others.
대표청구항▼
1. A topical delivery vehicle for treating a subject, comprising: an oil-based cream comprising a water-containing portion, the water-containing portion comprising:(a) a nitric oxide donor comprising L-arginine and/or L-arginine hydrochloride and/or a derivative of L-arginine, and(b) ibuprofen, wher
1. A topical delivery vehicle for treating a subject, comprising: an oil-based cream comprising a water-containing portion, the water-containing portion comprising:(a) a nitric oxide donor comprising L-arginine and/or L-arginine hydrochloride and/or a derivative of L-arginine, and(b) ibuprofen, wherein the ibuprofen in the water-containing portion is 7.5% or more by weight,wherein the water-containing portion has an ionic strength of between about 0.25 M and about 15 M. 2. The delivery vehicle of claim 1, wherein the nitric oxide donor comprises L-arginine. 3. The delivery vehicle of claim 1, wherein the water-containing portion comprises an ionic salt. 4. The delivery vehicle of claim 2, wherein the L-arginine is present at a concentration of at least 0.5% by weight/volume. 5. The delivery vehicle of claim 2, wherein the L-arginine is present at a concentration of between about 0.5% and about 25% by weight/volume. 6. The delivery vehicle of claim 1, wherein the water-containing portion has a pH between about 3 and about 11. 7. The delivery vehicle of claim 3, wherein the ionic salt is present in a concentration of between about 5% and about 50% by weight/volume. 8. The delivery vehicle of claim 3, wherein the ionic salt comprises one or more of sodium chloride, choline chloride, magnesium chloride, calcium chloride. 9. A topical delivery vehicle for treating a subject, comprising: an oil-based cream comprising a water-containing portion, the water containing portion comprising:(a) an ionic salt having an ionic strength of between about 0.25 M and about 15 M,(b) L-arginine and/or L-arginine hydrochloride and/or a derivative of L-arginine, and(c) ibuprofen at a concentration of 7.5% or more by weight. 10. The delivery vehicle of claim 9, wherein the ionic salt is selected from the group consisting of lithium chloride, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, choline chloride, sodium fluoride and lithium bromide. 11. The delivery vehicle of claim 10, wherein the ionic salt is selected from the group consisting of sodium chloride and potassium chloride. 12. The delivery vehicle of claim 9, wherein the derivative of L-arginine is selected from the group consisting of D,L-arginine, D-arginine, an alkyl ester of L-arginine, an alkyl ester of D-arginine, an L-arginine salt, a D-arginine salt, an alkyl ester salt of L-arginine, an alkyl ester salt of D-arginine, L-arginine glutamate, L-arginine butyrate, L-arginine glycolate, D-arginine hydrochloride, D-arginine glutamate; L-homoarginine, N-hydroxy-L-arginine, nitrosylated L-arginine, nitrosylated L-arginine, nitrosylated N-hydroxy-L-arginine, nitrosylated N-hydroxy-L-arginine, and combinations thereof. 13. The delivery vehicle of claim 9, wherein the L-arginine and/or L-arginine hydrochloride and/or a derivative of L-arginine is present at a concentration of between about 0.5% and about 25% by weight/volume. 14. The delivery vehicle of claim 1, wherein the nitric oxide donor comprises L-arginine hydrochloride. 15. The delivery vehicle of claim 1, wherein the water-containing portion comprising has an ionic strength of between about 1 M and about 15 M. 16. The delivery vehicle of claim 9, wherein the nitric oxide donor comprises L-arginine and/or arginine hydrochloride. 17. The delivery vehicle of claim 9, wherein the water-containing portion comprises an ionic salt at a concentration of between about 5% and about 50% by weight/volume. 18. The delivery vehicle of claim 17, wherein the ionic salt comprises one or more of sodium chloride, choline chloride, magnesium chloride, or calcium chloride. 19. The delivery vehicle of claim 9, wherein the water-containing portion comprising has an ionic strength of between about 1 M and about 15 M.
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