[특허]Systems and methods for mixing therapeutic agents before and/or during administration

Systems and methods for mixing therapeutic agents before and/or during administration 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	B01F-013/08 A61M-005/315 B01F-011/00 B01F-013/00 B01F-015/02 A61M-025/00
출원번호	US-0029477 (2011-02-17)
등록번호	US-9050414 (2015-06-09)
발명자 / 주소	Schoenle, Victor Leo Piippo Svendsen, Cassandra Ann Tibesar Jensen, Kristina Oreschnick, Mark B. Borrell, Alyson M.
출원인 / 주소	Cardiovascular Systems, Inc.
대리인 / 주소	Winthrop & Weinstine, P.A.
인용정보	피인용 횟수 : 0 인용 특허 : 38

초록 ▼

The invention provides systems and methods for mixing of therapeutic agents before and/or during the localized application of the therapeutic agents. Most preferably, the present invention provides systems and methods for mixing of therapeutic agents before and/or during administration of the agents within a biological lumen. Various embodiments of the present invention comprise systems and methods for inducing a mixing state in the therapeutic agents, thereby inducing and/or maintaining homogeneity of the agents before and/or during localized delivery.

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1. A system for mixing at least one therapeutic agent before and/or during localized delivery of the at least one therapeutic agent to treat a bodily disorder, comprising a mixing and delivery syringe, wherein the syringe comprises: a hollow body having a proximal end and a distal end, wherein the at least one therapeutic agent is stored;a distal port in fluid communication with the distal end of hollow body; anda plunger assembly comprising: a plunging base disposed within the hollow body;a fan disposed within the hollow body, the fan comprising rotatable blades extending radially from a rotatable central axle;a threaded shaft comprising a distal end rotatably coupled with the rotatable central axle for enabling rotational movement of the rotatable blades about the distal end of the threaded shaft;a threaded block in threaded communication with the threaded shaft; anda floating motor mounted on a proximal end of the threaded shaft;wherein, the motor is configured to rotate the threaded shaft;the rotation of the threaded shaft in a first direction induces threaded translation of the threaded shaft through the threaded block;the threaded translation of the threaded shaft induces axial translation of the floating motor, the fan and the plunging base towards the distal end of the hollow body; andthe axial translation of the fan induces the rotational movement of the rotatable blades about the distal end of the threaded shaft, wherein when resistance is encountered at the distal end of the hollow body, the floating motor reverses rotational direction to a second rotational direction, wherein the rotation of the threaded shaft in the second direction induces threaded translation of the threaded shaft through the threaded block and the threaded translation of the threaded shaft induxes axial translation of the floating motor, the fan and the plunging base towards the proximal end of the hollow body, wherein when resistance is encountered at the proximal end of the hollow body, the floating motor reverses rotational direction to the second rotational direction until resistance is encountered at the distal end of the hollow body. 2. The system of claim 1, wherein the bodily disorder is within a vasculature. 3. The system of claim 1, wherein the bodily disorder comprises restenosis. 4. The system of claim 1, wherein the at least one therapeutic agent comprises at least one therapeutic cell. 5. The system of claim 1, wherein the at least one therapeutic agent comprises a cytoskeletal inhibitor. 6. The system of claim 1, wherein the at least one therapeutic agent comprises a smooth muscle inhibitor. 7. The system of claim 1, wherein the rotation of the threaded shaft in a second direction opposite the first direction axially translates the fan and the plunging base towards the distal end of the hollow body. 8. The system of claim 7, wherein the rotational movement of the fan at least partially mixes the at least one therapeutic agent. 9. The system of claim 8, wherein the axial translation of the fan and the plunging base towards the distal end expels at least a portion of the at least one therapeutic agent through the distal port. 10. The system of claim 9, comprising a delivery sheath comprising: a distal end; anda proximal end in fluid communication with the distal port;wherein, the at least one therapeutic agent expelled through the distal port exits through the distal end of the delivery sheath. 11. The system of claim 10, comprising a therapeutic delivery means in fluid communication with the distal end of the delivery sheath, wherein the therapeutic deliver means is selected from the group consisting of: a balloon, a stent, and a delivery apparatus comprising one or more holes through which the homogeneous composition is released. 12. The system of claim 10, wherein the bodily disorder is within a vasulature and wherein the distal end of the delivery sheath is disposed proximate the bodily disorder. 13. The system of claim 7, wherein the rotational movement of the fan mixes the at least one therapeutic agent into a homogeneous composition.

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