Apparatus and method for managing chronic pain with infrared and low-level light sources
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-005/06
A61N-001/05
출원번호
US-0234102
(2011-09-15)
등록번호
US-9061135
(2015-06-23)
발명자
/ 주소
Keller, Matthew D.
Owen, James M.
Yuan, Shuming
출원인 / 주소
Lockheed Martin Corporation
대리인 / 주소
Lemaire, Charles A.
인용정보
피인용 횟수 :
1인용 특허 :
180
초록▼
Method and apparatus for infrared-light nerve stimulation plus low-level light therapy (INS-plus-LLLT) that includes providing an infrared-light nerve stimulation plus low-level light therapy (INS-plus-LLLT) device; implanting the INS-plus-LLLT device in the animal; emitting a plurality of infrared
Method and apparatus for infrared-light nerve stimulation plus low-level light therapy (INS-plus-LLLT) that includes providing an infrared-light nerve stimulation plus low-level light therapy (INS-plus-LLLT) device; implanting the INS-plus-LLLT device in the animal; emitting a plurality of infrared laser-light nerve-stimulation signals from the INS-plus-LLLT device and directing the plurality of infrared laser-light nerve stimulation signals toward a neural tissue of the animal in order to trigger an action potential response in the neural tissue; and generating a plurality of low-level light therapy signals using the INS-plus-LLLT device and directing the low-level light therapy signals toward the neural tissue of the animal, wherein the low-level light therapy signals are configured to be efficacious for pain management in order to reduce an acute pain of the animal.
대표청구항▼
1. An apparatus comprising: an infrared-light nerve stimulation plus low-level light therapy (INS-plus-LLLT) device configured to be implanted in an animal, and having a cuff configured to be positioned around a nerve bundle in the animal, wherein the INS-plus-LLLT device includes: a plurality of ne
1. An apparatus comprising: an infrared-light nerve stimulation plus low-level light therapy (INS-plus-LLLT) device configured to be implanted in an animal, and having a cuff configured to be positioned around a nerve bundle in the animal, wherein the INS-plus-LLLT device includes: a plurality of nerve-stimulation light sources that output pulsed infrared light nerve-stimulation signals in an inward direction toward the nerve bundle within the cuff, wherein the plurality of nerve-stimulation light sources is operable to output the pulsed infrared light nerve-stimulation signals into the nerve bundle at a penetration depth of approximately 400 μm;a low-level light therapy unit that outputs low-level light therapy signals in an outward direction from the cuff toward tissue of the animal located outside the cuff, wherein the LLLT signals configured to be efficacious for pain management, wherein the low-level light therapy unit is operable to output the low-level light therapy signals into the tissue at a penetration depth of approximately one centimeter; anda controller operatively coupled to control the plurality of nerve-stimulation light sources and the low-level light therapy unit. 2. The apparatus of claim 1 wherein the low-level light therapy signals include near-infrared light signals. 3. The apparatus of claim 1, wherein the infrared light nerve-stimulation signals are output for a duration of a first time period, wherein the low-level light therapy signals are output for a duration of a second time period, and wherein the second time period is longer than the first time period. 4. The apparatus of claim 3, wherein the first time period has at least some overlap with the second time period. 5. The apparatus of claim 3, wherein the first time period has no overlap with the second time period. 6. The apparatus of claim 1, wherein the plurality of nerve-stimulation light sources includes a plurality of vertical-cavity-surface-emitting-laser (VCSEL) arrays including a first VCSEL array and a second VCSEL array, wherein first VCSEL array is located on a first side of the nerve bundle of the animal and the second VCSEL array is located on a second side of the nerve bundle of the animal, opposite the first side, and wherein the low-level light therapy unit is located on the first side of the nerve bundle of the animal. 7. The apparatus of claim 1, wherein the pulsed infrared light nerve-stimulation signals have an energy density of about 0.4 joules-per-square-centimeter (0.4 J/cm2). 8. The apparatus of claim 1, wherein the plurality of nerve-stimulation light sources has an available power density of approximately 160 watts-per-centimeter-squared (W/cm2). 9. A method comprising: providing an infrared-light nerve stimulation plus low-level light therapy (INS-plus-LLLT) device having a cuff;implanting the INS-plus-LLLT device in the animal such that the cuff is positioned around a nerve bundle of the animal;emitting a plurality of pulsed infrared light nerve-stimulation signals from the INS-plus-LLLT device and directing the plurality of pulsed infrared light nerve-stimulation signals in an inward direction toward the nerve bundle within the cuff in order to trigger an action potential response in the nerve bundle, wherein the directing includes outputting the pulsed infrared light nerve stimulation signals into the nerve bundle at a penetration depth of approximately 400 μm; andgenerating a plurality of low-level light therapy signals using the INS-plus-LLLT device and directing the low-level light therapy signals in an outward direction from the cuff toward tissue of the animal located outside the cuff, wherein the low-level light therapy signals are configured to be efficacious for pain management of the animal, and wherein the directing of the low-level light therapy signals includes outputting the low-level light therapy signals into the tissue at a penetration depth of approximately one centimeter. 10. The method of claim 9, wherein the generating of the plurality of low-level light therapy signals includes generating near-infrared light signals. 11. The method of claim 9, wherein the emitting of the plurality of infrared light nerve-stimulation signals is performed for a duration of a first time period, wherein the generating of the plurality of low-level light therapy signals is performed for a duration of a second time period, and wherein the second time period is longer than the first time period. 12. The method of claim 11, wherein the first time period has at least some overlap with the second time period. 13. The method of claim 11, wherein the first time period has no overlap with the second time period. 14. The method of claim 9, wherein the pulsed infrared light nerve-stimulation signals have an energy density of about 0.4 joules-per-square-centimeter (0.4 J/cm2). 15. The method of claim 9, wherein the pulsed infrared light nerve-stimulation signals have an energy density of about 0.8 joules-per-square-centimeter (0.8 J/cm2). 16. An apparatus comprising: an infrared-light nerve stimulation plus low-level light therapy (INS-plus-LLLT) device configured to be implanted in an animal, and having a cuff configured to be positioned around a nerve bundle in the animal, wherein the INS-plus-LLLT device includes: means for emitting a plurality of pulsed infrared laser-light nerve-stimulation signals and directing the plurality of pulsed infrared laser-light nerve-stimulation signals in an inward direction toward the nerve bundle within the cuff in order to trigger an action potential response in the nerve bundle, wherein the means for emitting and directing the pulsed infrared laser-light nerve-stimulation signals outputs the pulsed infrared laser-light nerve-stimulation signals into the nerve bundle at a penetration depth of approximately 400 μm;means for generating a plurality of low-level light therapy signals and directing the low-level light therapy signals in an outward direction from the cuff toward tissue of the animal located outside the cuff in order to reduce a pain of the animal, wherein the means for generating and directing the low-level light therapy signals outputs the low-level light therapy signals into the tissue at a penetration depth of approximately one centimeter; andmeans for controlling the means for emitting and the means for generating. 17. The apparatus of claim 16, wherein the means for generating the plurality of low-level light therapy signals includes means for generating near-infrared light signals. 18. The apparatus of claim 16, wherein the means for emitting the plurality of infrared laser-light nerve-stimulation signals is configured to emit the plurality of infrared laser-light nerve-stimulation signals for a duration of a first time period, wherein the means for generating the plurality of low-level light therapy signals is configured to generate the plurality of low-level light therapy signals for a duration of a second time period, and wherein the second time period is longer than the first time period. 19. The apparatus of claim 18, wherein the first time period has at least some overlap with the second time period. 20. The apparatus of claim 16, wherein the pulsed infrared laser-light nerve-stimulation signals have an energy density of about 0.4 joules-per-square-centimeter (0.4 J/cm2).
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