Applicators for storing sterilizing, and dispensing an adhesive
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-035/00
A61B-017/00
B65D-035/36
B65D-051/22
A46B-011/00
A61F-013/40
A61B-019/00
출원번호
US-0287238
(2011-11-02)
등록번호
US-9066711
(2015-06-30)
발명자
/ 주소
Ruiz, Sr., Rafael
Zhang, Sheng
Krauss, Martin
출원인 / 주소
Adhezion Biomedical, LLC
대리인 / 주소
Stradley Ronon Stevens & Young, LLP
인용정보
피인용 횟수 :
0인용 특허 :
114
초록▼
Applicators for storing, sterilizing, and dispensing adhesives. The applicators comprise a porous tip, a body, and a container containing a polymerizable cyanoacrylate monomer adhesive. The applicators are sterilized by radiation, and following sterilization, the adhesive remains substantially unpol
Applicators for storing, sterilizing, and dispensing adhesives. The applicators comprise a porous tip, a body, and a container containing a polymerizable cyanoacrylate monomer adhesive. The applicators are sterilized by radiation, and following sterilization, the adhesive remains substantially unpolymerized for about twenty four months.
대표청구항▼
1. An applicator for storing and dispensing an adhesive comprising: a) a container comprising walls defining a chamber comprising a proximal end and a distal end and an opening at the distal end of the chamber, said walls comprising a single layer of a copolymer of acrylonitrile and methyl acrylate
1. An applicator for storing and dispensing an adhesive comprising: a) a container comprising walls defining a chamber comprising a proximal end and a distal end and an opening at the distal end of the chamber, said walls comprising a single layer of a copolymer of acrylonitrile and methyl acrylate or comprising multiple layers with the inner-most layer comprising a copolymer of acrylonitrile and methyl acrylate, said chamber further comprising a frangible distal seal, a frangible middle seal, and frangible a proximal seal covering the distal end of the chamber, said proximal seal having a side in communication with an adhesive stored in the chamber between the proximal seal and the proximal end of the chamber, said adhesive comprising a cyanoacrylate monomer, a free radical stabilizer in an amount of 200 ppm to 15,000 ppm, and an anionic stabilizer in an amount of about 10 ppm to about 200 ppm;b) a body comprising a proximal end and a distal end, a flange comprising at least one hole, a channel in communication with the hole, said channel extending through the body, and having an opening at the distal end of the body, and a grip capable of constricting the channel when inward pressure is applied to the grip,wherein the proximal end of the body is positioned between the middle frangible seal and the proximal frangible seal of the chamber when the applicator is not activated, and is capable of penetrating the proximal frangible seal when the body and the container are compressed together; andc) a porous tip in communication with the opening at the distal end of the channel;wherein the applicator is activated by compressing the body and the container together whereupon the flange penetrates the proximal seal and allows the adhesive to flow into the hole, through the channel, and out of the porous tip, and wherein at least the container is sterilized by radiation, and the adhesive stored in the container does not cure upon radiation exposure and for at least about twelve months of shelf storage thereafter. 2. The applicator of claim 1, wherein the cyanoacrylate monomer comprises a monomer of 2-octyl cyanoacrylate, dodecyl cyanoacrylate, 2-ethylhexyl cyanoacrylate, butyl cyanoacrylate, methyl cyanoacrylate, 3-methoxybutyl cyanoacrylate, 2-butoxyethyl cyanoacrylate, 2-isopropoxyethyl cyanoacrylate, 1-methoxy-2-propyl cyanoacrylate, or a combination thereof. 3. The applicator of claim 1, wherein the radiation is gamma radiation, electron beam radiation, or x-ray radiation. 4. The applicator of claim 1, wherein the adhesive stored in the chamber of the container does not cure upon radiation exposure and for at least about twenty four months of shelf storage thereafter. 5. The applicator of claim 1, wherein the porous tip comprises a swab, sponge, foam, or a brush. 6. The applicator of claim 1, further comprising a tip overlay removably placed over top of the porous tip. 7. An applicator for storing and dispensing an adhesive comprising: a) a flexible handle comprising a distal end, a housing for containing a removable adhesive container, and a female end of a luer lock at the distal end of the handle;b) a body comprising a proximal end and a distal end, a male end of a luer lock at the proximal end of the body, said male end being capable of connecting to the female end at the distal end of the handle, and a channel extending through the body, and having an opening at the distal end of the body;c) a porous tip in communication with the channel opening at the distal end of the body; andd) a removable container comprising a distal end, and comprising a single layer of a copolymer of acrylonitrile and methyl acrylate or comprising multiple layers with the inner-most layer comprising a copolymer of acrylonitrile and methyl acrylate, said container being capable of fitting within the housing, and further comprising a frangible seal covering the distal end of the container and having a side in communication with an adhesive stored in the container, said adhesive comprising a cyanoacrylate monomer, a free radical stabilizer in an amount of 200 ppm to 15,000 ppm, and an anionic stabilizer in an amount of about 10 ppm to about 200 ppm;wherein the applicator is activated by compromising the frangible seal whereupon the adhesive may flow into and through the channel and out of the porous tip, and wherein at least the container is sterilized by radiation, and the adhesive stored in the container does not cure upon radiation exposure and for at least about twelve months of shelf storage thereafter. 8. The applicator of claim 7, wherein the cyanoacrylate monomer comprises a monomer of 2-octyl cyanoacrylate, dodecyl cyanoacrylate, 2-ethylhexyl cyanoacrylate, butyl cyanoacrylate, methyl cyanoacrylate, 3-methoxybutyl cyanoacrylate, 2-butoxyethyl cyanoacrylate, 2-isopropoxyethyl cyanoacrylate, 1-methoxy-2-propyl cyanoacrylate, or a combination thereof. 9. The applicator of claim 7, wherein the container is a stick pack container. 10. The applicator of claim 7, wherein the frangible seal comprises aluminum foil laminated with a copolymer of acrylonitrile and methyl acrylate on the side in communication with the adhesive stored in the container. 11. The applicator of claim 7, wherein the radiation is gamma radiation, electron beam radiation, or x-ray radiation. 12. The applicator of claim 7, wherein the adhesive stored in the chamber of the container does not cure upon radiation exposure and for at least about twenty four months of shelf storage thereafter. 13. The applicator of claim 7, wherein the porous tip comprises a swab, sponge, foam, or a brush. 14. The applicator of claim 7, further comprising a tip overlay removably placed over top of the porous tip. 15. An applicator for storing and dispensing an adhesive comprising: a) a container comprising walls defining a chamber having a distal end and an opening at the distal end of the chamber, said walls comprising a single layer of a copolymer of acrylonitrile and methyl acrylate or comprising multiple layers with the inner-most layer comprising a copolymer of acrylonitrile and methyl acrylate, a frangible seal covering the opening and having a side in communication with the chamber, an adhesive comprising a cyanoacrylate monomer, a free radical stabilizer in an amount of 200 ppm to 15,000 ppm, and an anionic stabilizer in an amount of about 10 ppm to about 200 ppm stored in the chamber, and optionally, screw threads on the exterior of the walls of the container;b) a body comprising a proximal end and a distal end, a cavity at the proximal end of the body, a channel having a proximal end and a distal and, said channel being in communication with the cavity, extending through the body, and having an opening at the distal end of the channel, a grip capable of constricting the channel when inward pressure is applied to the grip, at least one projection in the cavity, wherein the projection is capable of penetrating the frangible seal when the body and the container are compressed together, and optionally, screw threads on the walls of the cavity capable of engaging the screw threads on the exterior of the walls of the container; andc) a porous tip in communication with the opening at the distal end of the channel;wherein the applicator is activated by compressing the body and the container together whereupon the projection penetrates the frangible seal and allows the adhesive to flow into and through the channel and out of the porous tip, and wherein at least the container is sterilized by radiation, and the adhesive stored in the chamber of the container does not cure upon radiation exposure and for at least about twelve months of shelf storage thereafter. 16. The applicator of claim 15, wherein the cyanoacrylate monomer comprises a monomer of 2-octyl cyanoacrylate, dodecyl cyanoacrylate, 2-ethylhexyl cyanoacrylate, butyl cyanoacrylate, methyl cyanoacrylate, 3-methoxybutyl cyanoacrylate, 2-butoxyethyl cyanoacrylate, 2-isopropoxyethyl cyanoacrylate, 1-methoxy-2-propyl cyanoacrylate, or a combination thereof. 17. The applicator of claim 15, wherein the frangible seal comprises aluminum foil laminated with a copolymer of acrylonitrile and methyl acrylate on the side in communication with the chamber. 18. The applicator of claim 15, wherein the radiation is gamma radiation, electron beam radiation, or x-ray radiation. 19. The applicator of claim 15, wherein the adhesive stored in the chamber of the container does not cure upon radiation exposure and for at least about twenty four months of shelf storage thereafter. 20. The applicator of claim 15, wherein the porous tip comprises a swab, sponge, foam, or a brush. 21. The applicator of claim 15, wherein the container comprises screw threads on the exterior of the walls of the container and the cavity comprises screw threads on the walls of the cavity, and the applicator is activated by screwing the body and the container together whereupon the projection penetrates the frangible seal and allows the adhesive to flow into and through the channel and out of the porous tip. 22. The applicator of claim 15, further comprising a tip overlay removably placed over top of the porous tip. 23. The applicator of claim 15, further comprising, a removable lock between the container and the body that prevents the body and the container from being compressed together and that, when removed, allows the body and the container to be compressed together. 24. The applicator of claim 1, further comprising, a removable lock between the container and the body that prevents the body and the container from being compressed together and that, when removed, allows the body and the container to be compressed together.
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