[특허]Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces

Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-038/28 A61K-009/50 A61K-009/16 A61K-038/13 A61K-038/25 A61K-038/27 A61K-038/29
출원번호	US-0797657 (2013-03-12)
등록번호	US-9066881 (2015-06-30)
발명자 / 주소	Hokenson, Mark Oberg, Keith A.
출원인 / 주소	MannKind Corporation
대리인 / 주소	K&L Gates LLP
인용정보	피인용 횟수 : 0 인용 특허 : 57

초록

Methods are provided for promoting the adsorption of an active agent to microparticles by modifying the structural properties of the active agent in order to facilitate favorable association to the microparticle.

대표청구항 ▼

1. A method of promoting binding of an active agent to a preformed crystalline diketopiperazine microparticle in suspension comprising: modifying the chemical potential of the active agent in the suspension by modifying the structure, flexibility, rigidity, solubility or stability of the active agent to allow for an energetically favorable interaction between the active agent and the preformed crystalline diketopiperazine microparticle independent of removal of solvent; wherein said modifying step causes adsorption of said active agent onto a surface of said preformed crystalline diketopiperazine microparticle to provide a coating of said active agent on said preformed crystalline diketopiperazine microparticle, said preformed crystalline diketopiperazine microparticle does not comprise an active agent, and said active agent comprises an antibody or fragment thereof. 2. The method of claim 1 wherein the antibody or fragment thereof is humanized or chimeric. 3. The method of claim 1 wherein the antibody or fragment thereof comprises F(ab), F(ab)2, or a single-chain antibody. 4. The method of claim 3 wherein the antibody or fragment thereof is fused to a polypeptide. 5. The method of claim 1 wherein the antibody or fragment thereof can recognize a disease-associated antigen. 6. The method of claim 5 wherein the disease-associated antigen is a tumor-associated antigen or an infectious pathogen-related antigen. 7. The method of claim 5 wherein the disease-associated antigen is one of cancer antigens, cytokines, infectious agents, inflammatory mediators, hormones, and cell surface antigens. 8. The method of claim 7 wherein the antibody or fragment thereof is one of anti-SSX-241-49 (synovial sarcoma, X breakpoint 2), anti-NY-ESO-1 (esophageal tumor associated antigen), anti-PRAME (preferentially expressed antigen of melanoma), anti-PSMA (prostate-specific membrane antigen), anti-Melan-A (melanoma tumor associated antigen), anti-tyrosinase (melanoma tumor associated antigen), and anti-MOPC-21 (myeloma plasma-cell protein). 9. The method of claim 1 wherein modifying the chemical potential of the active agent comprises altering solution conditions by adding an active agent modifier to the solution wherein said active agent modifier is selected from the group consisting of sodium chloride, hexylene-glycol (Hex-Gly), trehalose, glycine, polyethylene glycol, trimethylamine N-oxide, mannitol, proline, methanol, ethanol, trifluoroethanol, hexafluoroisopropanol, NaSCN, (CH3)3N—HCl, Na2NO3, NaClO4, cesium chloride, sodium citrate, sodium sulfate, and water. 10. The method of claim 9 wherein said active agent modifier is sodium chloride. 11. The method of claim 1 wherein said modifying the chemical potential of the active agent step comprises dissolving the active agent in a fluid phase of the suspension of preformed crystalline diketopiperazine microparticles and changing the pH of the fluid phase. 12. The method of claim 9 wherein the active agent modifier improves the structural stability of the active agent. 13. The method of claim 1 wherein the diketopiperazine is fumaryl diketopiperazine. 14. The method of claim 1 further comprising a step for removing the solvent after the adsorption has occurred.

이 특허에 인용된 특허 (57)

Ono Satoshi,JPX ; Yamafuji Tetsuo,JPX ; Yamamoto Hirohiko,JPX ; Egawa Hiroyuki,JPX ; Furuta Yousuke,JPX ; Kaga Hidetoshi,JPX, 2,3-diketopiperazine derivatives or their salts.
상세보기
Ono Satoshi,JPX ; Yamafuji Tetsuo,JPX ; Yamamoto Hirohiko,JPX ; Egawa Hiroyuki,JPX ; Furuta Yousuke,JPX ; Kaga Hidetoshi,JPX, 2,3-diketopiperazine derivatives or their salts.
상세보기
Edwards, David A.; Caponetti, Giovanni; Hrkach, Jeffrey S.; Lotan, Noah; Hanes, Justin; Ben-Jebria, Abdellaziz; Langer, Robert S., Aerodynamically light particles for pulmonary drug delivery.
상세보기
Crummenauer Michael (Oberworesbach DEX) Dietrich Uwe (Schwollen DEX) Galle Alfred (Idar-Oberstein DEX), Bottom-heated utensil for conductive or induction heating.
상세보기
Milstein Sam J., Carbon-substituted diketopiperazine delivery systems.
상세보기
Milstein, Sam J., Carbon-substituted diketopiperazine delivery systems.
상세보기
Milstein, Sam J., Carbon-substituted diketopiperazine delivery systems.
상세보기
Milstein,Sam J., Carbon-substituted diketopiperazine delivery systems.
상세보기
Sam J. Milstein, Carbon-substituted diketopiperazine delivery systems.
상세보기
Kirby, Kenneth B; Pettersson, Berno, Compositions for rapid and non-irritating transdermal delivery of pharmaceutically active agents and methods for formulating such compositions and delivery thereof.
상세보기
Steiner,Solomon S.; Gelber,Cohava; Feldstein,Robert S.; Pohl,Roderike, Compositions for treatment or prevention of bioterrorism.
상세보기
Platz, Robert M.; Patton, John S.; Foster, Linda; Eljamal, Mohammed, Devices compositions and methods for the pulmonary delivery of aerosolized medicaments.
상세보기
Kraft, Kelly S.; Somerville, Karla, Diketopiperazine microparticles with defined isomer contents.
상세보기
Leone-Bay, Andrea; Moye-Sherman, Destardi; Wilson, Bryan R., Diketopiperazine salts for drug delivery and related methods.
상세보기
Milstein Sam J., Diketopiperazine-based delivery systems.
상세보기
Milstein Sam J. (Larchmont NY), Diketopiperazine-based delivery systems.
상세보기
Platz Robert M. ; Brewer Thomas K. ; Boardman Terence D., Dispersible macromolecule compositions and methods for their preparation and use.
상세보기
Robert M. Platz ; Thomas K. Brewer ; Terence D. Boardman, Dispersible macromolecule compositions and methods for their preparation and use.
상세보기
Poole, Trent; Steiner, Solomon S., Inhalation apparatus.
상세보기
Stevenson, Cynthia; Hastedt, Jayne E.; Lehrman, S. Russ; Chiang, Hi-Shi; Bennett, David B.; Lesikar, David; Yang, Bing; Gong, David; Cabot, Kirsten, Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation.
상세보기
Anderson ; Jr. James H. (Carmel IN) De Felippis Michael R. (Indianapolis IN) Frank Bruce H. (Indianapolis IN) Havel Henry A. (Indianapolis IN), Insulin analog formulations.
상세보기
Colombo, Paolo; Cagnani, Stefano; Ventura, Paolo, Insulin highly respirable microparticles.
상세보기
Tanaka, Akihiro, Lens actuator.
상세보기
Matsumoto Fuyuhiko (Kawasaki JPX) Tani Masato (Kawasaki JPX) Enomoto Takamichi (Kanagawa JPX), Liquid crystal display cell with electrodes of substantially amorphous metal oxide having low resistivity.
상세보기
Solomon S. Steiner ; Robert Feldstein ; Huiling Lian ; Christopher A. Rhodes ; Gregory S. Shen, Method for drug delivery to the pulmonary system.
상세보기
Wilson, Bryan R.; Grant, Marshall, Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent.
상세보기
Steiner Solomon S. (Mount Kisco NY) Rhodes Christopher A. (Stamford CT) Shen Gregory S. (Hartsdale NY) McCabe R. Tyler (Yorktown NY), Method for making self-assembling diketopiperazine drug delivery system.
상세보기
Jensen Steen,DKX ; Hansen Philip,DKX, Method for producing powder formulation comprising an insulin.
상세보기
Hokenson, Mark; Oberg, Keith A., Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces.
상세보기
Oberg, Keith A., Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents.
상세보기
Hokenson, Mark; Oberg, Keith A., Method of drug formulation of compositions comprising crystalline microparticle surfaces.
상세보기
Robert M. Platz ; Shigenobu Kimura JP; Yu-ichiro Satoh JP; Linda C. Foster, Methods and compositions for the dry powder formulation of interferons.
상세보기
Robert Feldstein ; Solomon S. Steiner, Methods for fine powder formation.
상세보기
Robert M. Platz ; John S. Patton ; Linda Foster ; Mohammed Eljamal, Methods of spray-drying a drug and a hydrophobic amino acid.
상세보기
Steiner Solomon S. ; Feldstein Robert ; Lian Huiling ; Rhodes Christopher A. ; Shen Gregory S., Microparticles for lung delivery comprising diketopiperazine.
상세보기
O'Hagan, Derek; Singh, Manmohan; Ott, Gary, Microparticles with adsorbent surfaces, methods of making same, and uses thereof.
상세보기
Basu,Sujit K.; Hrkach,Jeffrey; Lipp,Michael; Elbert,Katharina; Edwards,David A., Particles for inhalation having sustained release properties.
상세보기
Cho Young W. (Chester NJ), Pharmaceutical compositions.
상세보기
Julie Straub ; Howard Bernstein ; Donald E. Chickering, III ; Sarwat Khattak ; Greg Randall, Porous drug matrices and methods of manufacture thereof.
상세보기
Straub, Julie; Altreuter, David; Bernstein, Howard; Chickering, III, Donald E.; Khattak, Sarwat; Randall, Greg, Porous drug matrices and methods of manufacture thereof.
상세보기
Gordon Marc S., Processes for spray drying aqueous suspensions of hydrophobic drugs and compositions thereof.
상세보기
Gordon Marc S., Processes for spray drying hydrophobic drugs in organic solvent suspensions.
상세보기
Gordon Marc S. ; Lord John D., Processes for spray drying solutions of hydrophobic drugs and compositions thereof.
상세보기
Bernstein Howard (Cambridge MA) Morrel Eric (Needham MA) Mathiowitz Edith (Brookline MA) Schwaller Kirsten (Duxbury MA) Beck Thomas R. (Concord MA), Protein microspheres and methods of using them.
상세보기
Patton, John S.; Kuo, Mei-Chang; Harris, J. Milton; Leach, Chester; Perkins, Kimberly; Bueche, Blaine, Pulmonary administration of chemically modified insulin.
상세보기
Solomon S. Steiner ; Rodney J. Woods ; Joseph W. Sulner, Purification and stabilization of peptide and protein pharmaceutical agents.
상세보기
Steiner, Solomon S.; Woods, Rodney J.; Sulner, Joseph W., Purification and stabilization of peptide and protein pharmaceutical agents.
상세보기
Feldstein Robert (Pelham NY) Glass John (Shoreham NY) Steiner Solomon S. (Mt. Kisco NY), Self assembling diketopiperazine drug delivery system.
상세보기
Platz, Robert M.; Patton, John S.; Foster, Linda; Eljamal, Mohammed, Spray drying of macromolecules to produce inhaleable dry powders.
상세보기
Hastedt, Jayne E.; Cabot, Kirsten M.; Gong, David K.; Hester, Dennis M., Storage stable powder compositions of interleukin-4 receptor.
상세보기
Kraft, Kelly Sullivan, Substituted diketopiperazine analogs for use as drug delivery agents.
상세보기
Bckstrm Kjell G. E. (Lund SEX) Dahlbck Carl M. O. (Lund SEX) Edman Peter (Bjrred SEX) Johansson Ann C. B. (Lund SEX), Systemic administration of a therapeutic preparation.
상세보기
Gordon Marc S. ; Clark Andrew ; Brewer Thomas K., Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients.
상세보기
Gordon, Marc S.; Clark, Andrew; Brewer, Thomas K., Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients.
상세보기
Marc S. Gordon ; Andrew Clark ; Thomas K. Brewer, Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients.
상세보기
Steiner,Solomon S.; Feldstein,Robert; Fog,Per B.; Poole,Trent, Unit dose capsules for use in a dry powder inhaler.
상세보기
Gonda Igor ; Rubsamen Reid M. ; Farr Stephen J., Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin.
상세보기

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces 원문보기

초록

대표청구항 ▼

연구과제 타임라인

이 특허에 인용된 특허 (57)

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces 원문보기

초록

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

이 특허에 인용된 특허 (57)

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트