Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change
Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.
대표청구항▼
1. A system for treating a target tissue of a patient, said system comprising: a handpiece having a size and a shape suitable for being supported in a hand of an operator, and at least one cooling fluid supply path disposed in the handpiece;a probe detachably coupled to the handpiece so as to be rep
1. A system for treating a target tissue of a patient, said system comprising: a handpiece having a size and a shape suitable for being supported in a hand of an operator, and at least one cooling fluid supply path disposed in the handpiece;a probe detachably coupled to the handpiece so as to be replaceable with respect to the handpiece, the probe comprising a probe body and an array of tissue penetrating needles extending distally from the probe body, wherein each tissue penetrating needle of the array of tissue penetrating needles comprises a proximal portion, a distal portion, a lumen extending distally from the probe body, a supply tube extending distally from the probe body within the lumen, the supply tube being detachably and fluidly coupled to the at least one cooling fluid supply path, and comprising a sealed and sharpened distal end insertable into the target tissue of the patient through a skin surface, wherein each tissue penetrating needle of the array of tissue penetrating needles has a size suitable for insertion through the skin surface without leaving a visible scar following removal thereof; anda cooling fluid source coupled to the at least one cooling fluid supply path, such that when cooling is initiated, cooling fluid flows into the lumens of the array of tissue penetrating needles so as to cool the target tissue below the skin surface to remodel the target tissue,wherein the supply tube comprises a fused silica supply tube. 2. The system of claim 1, wherein the cooling fluid source is self-contained within the handpiece. 3. The system of claim 1, wherein each tissue penetrating needle of the array of tissue penetrating needles is substantially linear. 4. The system of claim 1, wherein the cooling fluid source comprises a single-use cartridge. 5. The system of claim 4, wherein the single-use cartridge is disposed in the handpiece. 6. The system of claim 1, wherein the cooling fluid source comprises a refillable cartridge. 7. The system of claim 1, further comprising a housing, the cooling fluid source disposed therein, and wherein the housing is coupled to the handpiece with a flexible body. 8. The system of claim 1, further comprising a controller operably coupled to the at least one cooling fluid supply path so as to control a treatment time or a treatment temperature. 9. The system of claim 8, wherein the controller is disposed in the handpiece. 10. The system of claim 8, further comprising a controller housing, the controller being disposed therein, and wherein the controller housing is coupled to the handpiece with a flexible body. 11. The system of claim 1, further comprising a power source. 12. The system of claim 11, wherein the power source is disposed within the handpiece. 13. The system of claim 11, wherein the power source comprises a battery. 14. The system of claim 1, further comprising a skin protection element configured to protect the skin surface from injury caused by cooling from the cooling fluid source, the skin protection element adjacent a distal end of the probe body. 15. The system of claim 14, wherein the skin protection element comprises a resistive heater or a heated pad. 16. The system of claim 14, wherein the skin protection element comprises a biocompatible fluid, a cryoprotectant material, or insulation.
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