Hemostatic devices for promoting blood clotting can include a substrate (e.g., gauze, textile, sponge, sponge matrix, one or more fibers, etc.), a hemostatic material disposed thereon such as kaolin clay, and a binder material such as crosslinked calcium alginate with a high guluronate monomer molar
Hemostatic devices for promoting blood clotting can include a substrate (e.g., gauze, textile, sponge, sponge matrix, one or more fibers, etc.), a hemostatic material disposed thereon such as kaolin clay, and a binder material such as crosslinked calcium alginate with a high guluronate monomer molar percentage disposed on the substrate to substantially retain the hemostatic material material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood to accelerate clotting. Moreover, when exposed to blood, the binder has low solubility and retains a majority of the clay material on the gauze. A bandage that can be applied to a bleeding wound to promote blood clotting includes a flexible substrate and a gauze substrate mounted thereon.
대표청구항▼
1. A hemostatic device comprising: a substrate;a hemostatic clay material disposed on at least one side of the substrate; anda high-G crosslinked calcium alginate binder configured to immobilize the hemostatic clay material on the substrate;wherein the hemostatic device is subjected to a drying proc
1. A hemostatic device comprising: a substrate;a hemostatic clay material disposed on at least one side of the substrate; anda high-G crosslinked calcium alginate binder configured to immobilize the hemostatic clay material on the substrate;wherein the hemostatic device is subjected to a drying process;wherein the binder has an effect of substantially retaining the hemostatic clay material on the substrate when exposed to blood; andwherein the device is configured such that when treating bleeding, application of the device is capable of causing blood to be absorbed into the substrate and causing at least a portion of the hemostatic clay material to come into direct contact with blood to assist in accelerating clotting. 2. The device of claim 1, wherein the substrate comprises at least one of the following: a gauze material, a woven material, a sponge, a sponge matrix, or a foamed polymer. 3. The device of claim 1, further comprising a pharmaceutically-active composition selected from the group consisting of antibiotics, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines, compounds containing silver or copper ions, and combinations of the foregoing compositions. 4. The device of claim 1, wherein the substrate comprises a material selected from the group consisting of cotton, silk, wool, plastic, cellulose, rayon, polyester, polyurethane, polyethylene foam, PHEMA foam, polyacrylic acid foam, low-density polyether, polyvinyl alcohol, polyhydroxybutyrate methyl methacrylate, poly methylmethacrylate, or combinations of the foregoing. 5. The device of claim 1, wherein the substrate is flexible to allow the substrate to form to a shape of the bleeding wound and to retain a shape of the bleeding wound. 6. The device of claim 1, further comprising a release agent disposed on the hemostatic device. 7. The device of claim 1, wherein the binder also acts as a release agent. 8. The hemostatic device of claim 1, wherein the binder is applied to the substrate by a spraying process. 9. The hemostatic device of claim 1, wherein the binder and the hemostatic clay material are applied to the substrate by a spraying process. 10. The hemostatic device of claim 1, wherein the binder is applied to the substrate by immersing the substrate in a liquid comprising the binder. 11. The hemostatic device of claim 1, wherein the binder and the hemostatic clay material are applied to the substrate by immersing the substrate in a liquid comprising the binder and the hemostatic clay material. 12. A method of making a hemostatic device comprising: providing a high-G crosslinked calcium alginate binder solution;adding a hemostatic clay material to the solution;applying the solution containing the hemostatic clay material to a substrate;subjecting the substrate to a drying process;wherein the binder has an effect of immobilizing the hemostatic clay material on the substrate when immersed in saline and water; andwherein the device is configured such that when treating bleeding, application of the device is capable of causing blood to be absorbed into the substrate and causing at least a portion of the hemostatic clay material to come into direct contact with blood to assist in accelerating clotting. 13. The method of claim 12, further comprising providing a pharmaceutically-active composition selected from the group consisting of antibiotics, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines, compounds containing silver or copper ions, and combinations of the foregoing compositions. 14. The method of claim 12, wherein the substrate comprises a material selected from the group consisting of cotton, silk, wool, plastic, cellulose, rayon, polyester, polyurethane, polyethylene foam, PHEMA foam, polyacrylic acid foam, low-density polyether, polyvinyl alcohol, polyhydroxybutyrate methyl methacrylate, poly methylmethacrylate, or combinations of the foregoing. 15. The method of claim 12, wherein the substrate is flexible to allow the substrate to form to a shape of the bleeding wound and to retain a shape of the bleeding wound. 16. The method of claim 12, further comprising disposing a release agent on the hemostatic device. 17. The method of claim 16, wherein the release agent is selected from the group consisting of calcium alginate, polyvinyl alcohol, glycerol, silicone, carboxymethyl cellulose, chitosan, hyaluronan, acid soluble collagen, and gelatin. 18. A hemostatic device comprising: a sponge matrix;a hemostatic clay material; anda high-G crosslinked calcium alginate binder configured to immobilize the hemostatic clay material to the sponge;wherein the device is configured such that when treating bleeding, application of the device is capable of causing blood to be drawn into the sponge matrix and causing at least a portion of the hemostatic clay material to come into direct contact with blood to assist in accelerating clotting. 19. The device of claim 18, wherein the sponge matrix comprises a foamed polymer. 20. The device of claim 19, wherein the foamed polymer includes a material selected from the group consisting of polyester, polyurethane, polyethylene foam, PHEMA foam, polyacrylic acid foam, low-density polyether, polyvinyl alcohol, polyhydroxybutyrate methyl methacrylate, poly methylmethacrylate, or combinations of the foregoing. 21. The device of claim 18, wherein the hemostatic clay material comprises kaolinite. 22. The device of claim 18, wherein the hemostatic clay material is selected from the group consisting of attapulgite, bentonite, kaolin, kaolinite, and combinations of the foregoing materials. 23. The device of claim 18, further comprising a pharmaceutically-active composition selected from the group consisting of antibiotics, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines, compounds containing silver or copper ions, and combinations of the foregoing compositions. 24. The device of claim 18, wherein the sponge is highly flexible to allow the sponge to form to a shape of the bleeding wound and to retain a shape of the bleeding wound. 25. The device of claim 18, further comprising a release agent disposed on the hemostatic device. 26. The device of claim 18, wherein the binder also acts as a release agent. 27. The hemostatic device of claim 18, wherein the binder is applied to the sponge by a spraying process. 28. The hemostatic device of claim 18, wherein the binder and the hemostatic clay material are applied to the sponge by a spraying process. 29. The hemostatic device of claim 18, wherein the binder is applied to the substrate by immersing the sponge in a liquid comprising the binder. 30. The hemostatic device of claim 18, wherein the binder and the hemostatic clay material are applied to the sponge by immersing the sponge in a liquid comprising the binder and the hemostatic clay material. 31. The hemostatic device of claim 18 further comprising compressing at least a portion of the sponge during the application process.
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