A device for sealing a patent foramen ovale (PFO) in the heart is provided. The device includes a left atrial anchor adapted to be placed in a left atrium of the heart, a right atrial anchor adapted to be placed in a right atrium of the heart, and an elongate member adapted to extend through the pas
A device for sealing a patent foramen ovale (PFO) in the heart is provided. The device includes a left atrial anchor adapted to be placed in a left atrium of the heart, a right atrial anchor adapted to be placed in a right atrium of the heart, and an elongate member adapted to extend through the passageway and connect the left and right atrial anchors. The right atrial anchor preferably includes a plurality of arms and a cover attached to the arms. The left atrial anchor also includes a plurality of arms and preferably does not include a cover. Preferably, the elongate member has a first end of fixedly connected to the left atrial anchor and a portion, proximal to the first end, releasably connected to the right atrial anchor. Preferably, the elongate member is flexible.
대표청구항▼
1. A device for sealing a passageway in a human heart, the device comprising: a first anchor adapted to be placed proximate a first end of the passageway, the first anchor deployable from a collapsed state to an expanded state, the first anchor having an open structure that permits blood to pass thr
1. A device for sealing a passageway in a human heart, the device comprising: a first anchor adapted to be placed proximate a first end of the passageway, the first anchor deployable from a collapsed state to an expanded state, the first anchor having an open structure that permits blood to pass through the first anchor when the first anchor is in the expanded state;a second anchor adapted to be placed proximate a second end of the passageway, the second anchor deployable from a collapsed state to an expanded state, the second anchor having a covering for occluding blood flow through the second anchor when the second anchor is in the expanded state;an elongate member adapted to extend through the passageway and connect the first and second anchors; anda locking element positionable on the elongate member;wherein the second anchor is movable along the elongate member relative to the first anchor, wherein the locking element is movable along the elongate member towards the second anchor to secure the location of the second anchor on the elongate member, and wherein the locking element is arranged to engage the outer surface of the elongate member so as to permit movement of the locking element along the elongate member towards the second anchor but resist movement of the locking element along the elongate member away from the second anchor, whereby the locking element is configured to resist movement of the second anchor away from the first anchor along the elongate member. 2. The device of claim 1, wherein the passageway is a patent foramen ovale. 3. The device of claim 1, wherein the first anchor includes a plurality of arms radiating from a central hub of the first anchor. 4. The device of claim 1, wherein the second anchor includes a plurality of arms radiating from a central hub of the second anchor. 5. The device of claim 1, wherein the elongate member is flexible. 6. The device of claim 1, wherein the first anchor pivots relative to the elongate member. 7. The device of claim 1, wherein the second anchor pivots relative to the elongate member. 8. The device of claim 1, wherein the elongate member is capable of moving through the second anchor to vary a length of the elongate member between the first and second anchors. 9. The device of claim 1, wherein the elongate member is configured to move through the second anchor to vary a tension of the elongate member. 10. The device of claim 1, wherein the second anchor includes a plurality of arms, and wherein the covering spans between its plurality of arms. 11. The device of claim 10, wherein the first anchor includes a plurality of arms, and wherein the first anchor does not include structure spanning between its plurality of arms. 12. The device of claim 5, wherein the elongate member is sufficiently flexible to conform to a shape of the passageway. 13. The device of claim 1, wherein the elongate member is a braided structure. 14. The device of claim 1, wherein the elongate member is a multifilar structure. 15. The device of claim 1, wherein the elongate member is configured to permanently connect the first and second anchors implanted in the heart. 16. The device of claim 1, wherein at least a portion of the elongate member is configured to remain implanted in the heart with the device. 17. The device of claim 1, wherein the elongate member has a first end fixedly connected to the first anchor. 18. The device of claim 1, wherein the locking element is tubular. 19. A method of sealing a passageway in a heart, comprising: deploying a first anchor from a collapsed state to an expanded state, the first anchor having an open structure that permits blood to pass through the first anchor when the first anchor is in the expanded state;positioning the first anchor in the expanded state against a first portion of body tissue proximate a first end of the passageway;deploying a second anchor from a collapsed state to an expanded state, the second anchor having a covering for occluding blood flow through the second anchor when the second anchor is in the expanded state, the second anchor being movable along an elongate member relative to the first anchor, the elongate member extending through the passageway and connecting the first and second anchors;positioning the second anchor in the expanded state against a second portion of body tissue proximate a second end of the passageway; andmoving a locking element along the elongate member towards the second anchor to secure the location of the second anchor on the elongate member, the locking element being arranged to engage the outer surface of the elongate member so as to permit movement of the locking element along the elongate member towards the second anchor but resist movement of the locking element along the elongate member away from the second anchor, whereby the locking element is configured to resist movement of the second anchor away from the first anchor along the elongate member. 20. The method of claim 19, wherein the passageway is a patent foramen ovale. 21. The method of claim 19, wherein moving the locking element along the elongate member towards the second anchor comprises moving the locking element to a position proximate the second anchor, whereby the locking element resists movement of the second anchor away from the first anchor. 22. The method of claim 21, further comprising severing the elongate member adjacent the second anchor. 23. The method of claim 19, wherein the second anchor includes a plurality of arms, and wherein the covering spans between its plurality of arms. 24. The method of claim 23, wherein the first anchor includes a plurality of arms, and wherein the first anchor does not include structure spanning between its plurality of arms. 25. The method of claim 20, wherein the elongate member is sufficiently flexible to conform to a shape of the patent foramen ovale. 26. The method of claim 19, further comprising moving the second anchor along the elongate member towards the first anchor prior to moving the locking element along the elongate member towards the second anchor. 27. The device of claim 1, wherein the locking element is movable along the elongate member to a position engaging the second anchor, whereby the locking element resists movement of the second anchor away from the first anchor. 28. The method of claim 19, wherein moving the locking element along the elongate member towards the second anchor comprises moving the locking element to a position engaging the second anchor, whereby the locking element resists movement of the second anchor away from the first anchor. 29. The device of claim 1, wherein the elongate member has a substantially smooth outer surface, and wherein the locking element includes a plurality of projecting grips arranged to engage the outer surface of the elongate member so as to permit movement of the locking element along the elongate member towards the second anchor but resist movement of the locking element along the elongate member away from the second anchor. 30. The method of claim 19, wherein the elongate member has a substantially smooth outer surface, and wherein the locking element includes a plurality of projecting grips arranged to engage the outer surface the outer surface of the elongate member so as to permit movement of the locking element along the elongate member towards the second anchor but resist movement of the locking element along the elongate member away from the second anchor. 31. The device of claim 1, wherein the covering of the second anchor comprises a porous material having a porosity sufficient to encourage ingrowth of tissue. 32. The device of claim 19, wherein the covering of the second anchor comprises a porous material having a porosity sufficient to encourage ingrowth of tissue.
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