Inhibition of bacterial biofilms with imidazole derivatives
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/4168
C07D-233/64
A01N-043/52
A01N-043/50
A61K-008/49
A61L-027/54
A61L-029/16
A61L-031/16
A61Q-011/00
A61Q-017/00
C07D-233/88
C07D-235/30
C07D-401/14
C07D-403/12
출원번호
US-0150024
(2014-01-08)
등록번호
US-9084423
(2015-07-21)
발명자
/ 주소
Melander, Christian
Cavanagh, John
Huigens, III, Robert W.
Ballard, T. Eric
Richards, Justin J.
출원인 / 주소
North Carolina State University
대리인 / 주소
Myers Bigel Sibley & Sajovec, P.A.
인용정보
피인용 횟수 :
0인용 특허 :
9
초록
Disclosure is provided for imidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.
대표청구항▼
1. A compound of Formula (II): wherein: R1 and R2 are each independently selected from the group consisting of: H, hydroxy, acyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclo, aryl, heteroaryl, alkoxy, amino, amide, sulfone, oxo, oxy, nitro, carbonyl, carboxy, and amino acid sidechain;or a phar
1. A compound of Formula (II): wherein: R1 and R2 are each independently selected from the group consisting of: H, hydroxy, acyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclo, aryl, heteroaryl, alkoxy, amino, amide, sulfone, oxo, oxy, nitro, carbonyl, carboxy, and amino acid sidechain;or a pharmaceutically acceptable salt or prodrug thereof. 2. The compound of claim 1, wherein said compound represented by Formula (II) is a compound of Formula (II)(a): or a pharmaceutically acceptable salt or prodrug thereof. 3. A compound of Formula (II)(b): wherein: R3 and R4 are each independently selected from the group consisting of: H, hydroxy, acyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclo, aryl, heteroaryl, alkoxy, amino, amide, sulfone, oxo, oxy, nitro, carbonyl, carboxy, and amino acid sidechain;or a pharmaceutically acceptable salt or prodrug thereof. 4. The compound of claim 3, wherein R3 and R4 are each independently selected from the group consisting of aryl and heteroaryl. 5. The compound of claim 3, wherein R3 and R4 are each independently a group: wherein: X, Y and Z are each independently selected from the group consisting of: H, methyl, Br and Cl. 6. The compound of claim 5, wherein R3 and R4 are the same, and wherein X and Y are each independently selected from the group consisting of: H, Br and Cl; and Z is H or methyl. 7. The compound of claim 3, wherein said compound represented by Formula (II) is a compound of Formula (II)(b)(vi): or a pharmaceutically acceptable salt or prodrug thereof. 8. The compound of claim 3, wherein two asymmetric carbon atoms of said compound have a trans configuration. 9. The compound of claim 3, wherein two asymmetric carbon atoms of said compound have a cis configuration. 10. A composition comprising a carrier and an effective amount of the compound of claim 3. 11. The composition of claim 10, wherein said composition is a dentifrice composition. 12. The dentifrice composition of claim 11, wherein the dentifrice composition comprises a toothpaste, mouthwash, chewing gum, dental floss, or dental cream. 13. A composition comprising the compound of claim 3 in a pharmaceutically acceptable carrier. 14. A composition comprising the compound of claim 3 covalently coupled to a substrate. 15. The composition of claim 14, wherein said substrate comprises a polymeric material. 16. The composition of claim 14, wherein said substrate comprises a solid support. 17. The composition of claim 14, wherein said substrate is selected from the group consisting of a drainpipe, glaze ceramic, porcelain, glass, metal, wood, chrome, plastic, vinyl, and formica. 18. The composition of claim 14, wherein the substrate is selected from the group consisting of shower curtains or liners, upholstery, laundry, and carpeting. 19. The composition of claim 14, wherein said substrate is a ship hull or portion thereof. 20. The composition of claim 14, wherein the substrate is a food contact surface. 21. A coating composition, comprising: (a) a film-forming resin;(b) a solvent that disperses said resin;(c) the compound of claim 3; and(d) optionally, at least one pigment. 22. The coating composition of claim 21, wherein said compound is covalently coupled to said resin. 23. The coating composition of claim 21, wherein said resin comprises a polymeric material. 24. A substrate coated with the coating composition of claim 21. 25. The substrate of claim 24, wherein said substrate comprises a polymeric material. 26. The substrate of claim 24, wherein said substrate comprises a solid support. 27. The substrate of claim 24, wherein said substrate is selected from the group consisting of a drainpipe, glaze ceramic, porcelain, glass, metal, wood, chrome, plastic, vinyl, and formica. 28. The substrate of claim 24, wherein the substrate is selected from the group consisting of shower curtains or liners, upholstery, laundry, and carpeting. 29. The substrate of claim 24, wherein said substrate is a ship hull or portion thereof. 30. The substrate of claim 24, wherein the substrate is a food contact surface. 31. A medical device comprising: (a) a medical device substrate; and(b) the compound of claim 1, either coating the substrate, or incorporated into the substrate. 32. The medical device of claim 31, wherein said medical device substrate is selected from the group consisting of stents, fasteners, ports, catheters, scaffolds and grafts. 33. The medical device of claim 31, wherein said compound is covalently coupled to said substrate. 34. A medical device comprising: (a) a medical device substrate; and(b) the compound of claim 3, either coating the substrate, or incorporated into the substrate. 35. The medical device of claim 34, wherein said medical device substrate is selected from the group consisting of stents, fasteners, ports, catheters, scaffolds and grafts. 36. The medical device of claim 34, wherein said compound is covalently coupled to said substrate.
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