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Embodiments include dental appliances, dental appliance systems, and methods of making and using such appliances. In one embodiment, a dental appliance includes a shell having a number of cavities to receive one or more teeth, each cavity having an inner surface. At least a first portion of a partic

Embodiments include dental appliances, dental appliance systems, and methods of making and using such appliances. In one embodiment, a dental appliance includes a shell having a number of cavities to receive one or more teeth, each cavity having an inner surface. At least a first portion of a particular cavity is scaled-up in size by a first selected percentage over one or more dimensions of a corresponding tooth to provide a first space between the cavity inner surface and the corresponding tooth surface. At least a second portion of the particular cavity is scaled-up in size by a second scaled-up percentage over one or more dimensions of a corresponding gingival outer surface adjacent to the corresponding tooth to provide a second shape.

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1. A dental appliance comprising: a shell having a number of cavities to receive and reposition one or more teeth, each cavity having an inner surface; andwhere at least a first portion of a particular cavity is scaled-up in size by a first selected uniform percentage over one or more dimensions of

1. A dental appliance comprising: a shell having a number of cavities to receive and reposition one or more teeth, each cavity having an inner surface; andwhere at least a first portion of a particular cavity is scaled-up in size by a first selected uniform percentage over one or more dimensions of a corresponding tooth to provide a first space for the at least first portion of the particular cavity between the cavity inner surface and the corresponding tooth, where the particular cavity contains a chemical to treat the corresponding tooth, wherein the at least first portion of the particular cavity covers the corresponding tooth;where at least a second portion of the particular cavity is scaled-up in size by a second uniform scaled-up percentage over one or more dimensions of a corresponding gingival outer surface adjacent to the corresponding tooth to provide a second space, the second space being contiguous with the first space, wherein the second scaled-up percentage is different than the first selected percentage, wherein the at least second portion of the particular cavity covers the corresponding gingival outer surface;where the inner surface of the particular cavity has scaled-up proportions of the dimensions relative to the corresponding tooth; andwhere the first selected percentage is based on one or more properties of the chemical used to treat the corresponding tooth. 2. The appliance of claim 1, where the particular cavity is scaled-up in size by the first selected uniform percentage from the one or more dimensions to provide the first space between an inner surface of the cavity and a corresponding tooth, wherein the first space and the second space are uniform spaces. 3. The appliance of claim 1, including spacer structures formed into the polymeric shell to offset the inner surface of the scaled-up cavity from a corresponding tooth. 4. The appliance of claim 1, where the at least second portion of the cavity extends around a gingival margin area supporting the corresponding tooth so as to form a pocket of space between the inner surface of the cavity and the corresponding gingival margin area. 5. The appliance of claim 1, where the scale-up of the at least first portion of the cavity is in at least one of a buccal and lingual direction. 6. The appliance of claim 1, where the scale-up of the at least first portion of the cavity is on one side of the tooth to leave uniform space between the tooth and the inner surface of the particular cavity at the at least first portion. 7. The appliance of claim 1, where the at least first portion of the particular cavity is sized to contain fluoride to treat the corresponding tooth, the first selected uniform percentage being 1%. 8. The appliance of claim 1, where the at least first portion of particular cavity is sized to contain a whitening agent to treat the corresponding tooth, the first selected uniform percentage being 5%. 9. The appliance of claim 1, where the first space is provided between the first portion of the particular cavity and a buccal surface of the corresponding tooth. 10. The appliance of claim 1, where the second space is arranged to hold a reservoir of material in contact with the corresponding gingival outer surface to treat periodontal conditions. 11. The appliance of claim 1, where the second space is arranged to hold material selected from the group including: gel, paste, foam, liquid, and powder. 12. A system of removable dental positioning appliances comprising: a series of shells adapted to reposition one or more teeth from a first configuration to a successive configuration, each shell having a number of cavities to receive one or more teeth and each cavity having an inner surface;where at least a first portion of a particular cavity is scaled-up in size by a first selected uniform percentage over one or more dimensions of a corresponding tooth to provide a first space for the at least first portion between the cavity inner surface that contains a chemical to treat the corresponding tooth, wherein the at least first portion of the particular cavity covers the corresponding tooth;where at least a second portion of the particular cavity is scaled-up in size by a second uniform scaled-up percentage over one or more dimensions of a corresponding gingival outer surface adjacent to the corresponding tooth to provide a second space, the second space being contiguous with the first space, wherein the second scaled-up percentage is different than the first selected percentage, wherein the at least second portion of the particular cavity covers the corresponding gingival outer surface;where the inner surface of the particular cavity that is scaled-up in size has scaled-up proportions of the dimensions relative to the corresponding tooth;where the first selected percentage is based on one or more properties of the chemical used to treat the corresponding tooth; andwhere the inner surface of the particular cavity includes spacer structures to offset the inner surface from the corresponding tooth. 13. The system of claim 12, where the one or more properties of the chemical includes a particular viscosity of the chemical, a particular quantity of the chemical, and a particular form of delivery of the chemical. 14. The system of claim 12, where the at least first portion of particular cavity is sized to measured dimensions of a corresponding tooth. 15. The system of claim 12, where the at least first portion of the particular cavity scaled-up in size by the first selected uniform percentage comprises a cavity scaled-up in size by the first selected uniform percentage sized to contain fluoride to treat the corresponding tooth, the first selected uniform percentage being within a range of 1% to 0% but is at least greater than 0%. 16. The system of claim 12, where the at least first portion of the particular cavity scaled-up in size by the first selected uniform percentage comprises a cavity sized to contain a whitening agent to treat the corresponding tooth, the first selected uniform percentage being 5%. 17. The system of claim 12, where the at least second portion of the particular cavity scaled-up in size comprises a cavity that extends around a gingival margin area supporting the corresponding tooth so as to form a pocket of space between the inner surface of the cavity and the gingival margin area.