초록

Disclosed is a preservative or antimicrobial system, and methods for its use, that includes at least one ester of salicylic acid and glycerin or a salt thereof.

대표청구항 ▼

1. A preservative or anti-microbial system comprising an effective amount of at least three of the following esters of salicylic acid and glycerin or salts thereof for inhibiting growth of a microorganism: 2. The preservative or anti-microbial system of claim 1, comprising all four of said esters o

1. A preservative or anti-microbial system comprising an effective amount of at least three of the following esters of salicylic acid and glycerin or salts thereof for inhibiting growth of a microorganism: 2. The preservative or anti-microbial system of claim 1, comprising all four of said esters of salicylic acid and glycerin or salts thereof. 3. The preservative or anti-microbial system of claim 2, comprising: 4. The preservative or anti-microbial system of claim 2, comprising: 5. The preservative or anti-microbial system of claim 1, further comprising glycerin. 6. The preservative or anti-microbial system of claim 5, comprising 15 to 25 wt % of glycerin. 7. The preservative or anti-microbial system of claim 6, comprising 18 to 22 wt % of glycerin. 8. The preservative or anti-microbial system of claim 1, further comprising a secondary preservative or antimicrobial agent. 9. The preservative or antimicrobial system of claim 8, wherein the secondary preservative or antimicrobial agent is selected from the group consisting of at least one of iodopropynyl butylcarbamate, capylyl glycol, imidazolidinyl urea, a paraben, methylsothiazoline, chlorphenesin, or benzoic acid or any combination thereof. 10. The preservative or antimicrobial system of claim 9, comprising iodopropynyl butylcarbamate or capylyl glycol or both of iodopropynyl butylcarbamate and capylyl glycol. 11. The preservative or anti-microbial system of claim 10, comprising: from 20 to 25% w/w of caprylyl glycol; andfrom 70 to 80% w/w of the ester/esters of salicylic acid and glycerin. 12. The preservative or anti-microbial system of claim 11, comprising: from 0.5 to 2% w/w of iodopropynyl butylcarbamate;from 20 to 25% w/w of caprylyl glycol; andfrom 70 to 80% w/w of the ester/esters of salicylic acid and glycerin. 13. The preservative or antimicrobial system of claim 9, comprising imidazolidinyl urea. 14. The preservative or anti-microbial system of claim 13, comprising: from 20 to 25% w/w of imidazolidinyl urea; andfrom 70 to 80% w/w of the ester/esters of salicylic acid and glycerin. 15. The preservative or anti-microbial system of claim 1, wherein said system is effective in inhibiting the growth of a gram-positive bacteria, a gram-negative bacteria, a yeast or a mold. 16. The preservative or anti-microbial system of claim 15, wherein the gram-positive bacteria is Staphyloccus aureus and/or Staphylococcus epidermidis, wherein the gram-negative bacteria is oxidative gram-gram negative bacteria selected from the group consisting of at least one of Pseudomonas aeruginosa, Pseudomonas cepacia, and/or Pseudomonas putida, wherein the gram-negative bacteria is fermentative gram-negative bacteria selected from the group consisting of Escherichia coli, Klebsiella pneumonia, and/or Enterobacter aerogenes, wherein the yeast is Candida albicans, and wherein the mold is Aspergillus niger. 17. The preservative or anti-microbial system of claim 1, wherein said system is substantially anhydrous. 18. The preservative or anti-microbial system of claim 1, wherein said system does not include salicylic acid and/or does not include a paraben. 19. The preservative or anti-microbial system of claim 1, wherein said system is comprised within a cosmetic formulation or a pharmaceutical formulation. 20. The preservative or anti-microbial system of claim 19, wherein said formulation is an emulsion, solution, or ointment. 21. The preservative or anti-microbial system of claim 1, wherein said system is a disinfectant formulation or a cleansing formulation. 22. A method of inhibiting the growth of a microorganism comprising contacting the microorganism with the preservative or anti-microbial systems of claim 1, wherein the growth of the microorganism is inhibited. 23. A method of inhibiting the growth of a microorganism in a cosmetic or pharmaceutical formulation comprising adding the preservative or anti-microbial system of claim 1 to said formulation, wherein growth of the microorganism in said formulation is inhibited. 24. A method of stabilizing an emulsion that includes caprylyl glycol comprising adding the preservative or anti-microbial system of claim 1 to the emulsion, wherein the emulsion is stabilized by the addition of said preservative or anti-microbial system.