A neuromodulation device includes an ablation valve with electrodes provided about its circumference. The valve dynamically reacts to fluid pressure within the vessel. When a pressure within and distal said ablation valve is greater than the body fluid pressure within the vessel, said ablation valve
A neuromodulation device includes an ablation valve with electrodes provided about its circumference. The valve dynamically reacts to fluid pressure within the vessel. When a pressure within and distal said ablation valve is greater than the body fluid pressure within the vessel, said ablation valve closes and the electrodes move out of contact with the endothelium of the vessel. When a pressure within and distal the ablation valve is less than the body fluid pressure upstream of the valve, the valve opens such that the electrodes are in circumferential contact with the endothelium. Fluid can be injected into the valve to alter the local pressure about the valve and force the electrodes into contact with the endothelium.
대표청구항▼
1. A neuromodulation device for use in a vessel having an endothelium and carrying body fluid with a fluid pressure, comprising: a) an elongate flexible introducer having a proximal end and distal end;b) an expandable ablation valve at said distal end of said introducer, said ablation valve having a
1. A neuromodulation device for use in a vessel having an endothelium and carrying body fluid with a fluid pressure, comprising: a) an elongate flexible introducer having a proximal end and distal end;b) an expandable ablation valve at said distal end of said introducer, said ablation valve having a proximal surface, a distal surface, a circumference, and a plurality of electrodes displaced about said circumference, said ablation valve adapted to dynamically react to fluid pressure within the vessel such that, i) when a pressure within and on said distal surface of said ablation valve is less than the fluid pressure on said proximal surface of said ablation valve, said ablation valve is in a retreated configuration in which said electrodes are configured to be out of circumferential contact with the endothelium of the vessel, andii) when said pressure within and on said distal surface of said ablation valve is greater than the fluid pressure on said proximal surface of said ablation valve, said ablation valve is in a contact configuration in which said electrodes are configured to be in circumferential contact with the endothelium of the vessel; andc) a conductor extending along said introducer, said conductor having a distal end electrically coupled to said electrodes of said ablation valve and a proximal end extended to a terminal for coupling to a RF generator. 2. A neuromodulation device according to claim 1, wherein: said introducer is a catheter defining a lumen having a distal opening that is located at an interior of said ablation valve. 3. A neuromodulation device according to claim 1, wherein: a proximal end of said ablation valve is located substantially coincident with said distal opening of said lumen. 4. A neuromodulation device according to claim 1, wherein: said ablation valve expands to said contact configuration during diastole, and moves to said retreated configuration during systole. 5. A neuromodulation device according to claim 1, wherein: said ablation valve comprises an inner layer defined by electrospun fibers, and an expandable structure over said inner layer comprising a braid of filaments which cross over each other, at least a plurality of said filaments having a spring bias to assume a preferred crossing angle relative to each other, a proximal end of said braid of filaments radially collapsed and coupled to the distal end of said elongate introducer. 6. A neuromodulation device according to claim 5, wherein: in each of said contact configuration and said retreated configuration, said ablation valve has respective frustoconical shapes. 7. A neuromodulation device according to claim 5, wherein: said filaments define at least a plurality of electrodes. 8. A neuromodulation device according to claim 7, wherein: said filaments comprise insulated wires, and each said electrode is defined at a portion of said wire at which a portion of the insulation has been removed to expose an interior conductive metal of said wire. 9. A neuromodulation device according to claim 7, wherein: said filaments include non-conductive filaments. 10. A neuromodulation device according to claim 7, wherein: an outer layer of electrospun fibers provided over said filaments. 11. A neuromodulation device according to claim 7, wherein: said device is bipolar. 12. A neuromodulation device according to claim 11, wherein: said electrodes includes first and second electrically isolated sets of electrodes, and said conductor comprises first and two electrically isolated conductors, said first conductor electrically coupled to said first set of electrodes, and said second electrode coupled to said second set of electrodes. 13. A neuromodulation device according to claim 7, wherein: said device is monopolar. 14. A neuromodulation device according to claim 1, further comprising: a sleeve into which said introducer and ablation valve are provided for delivery to a treatment site, said introducer longitudinally displaceable relative to said sleeve to advance said ablation valve out of a distal end of said sleeve. 15. A neuromodulation device according to claim 1, further comprising: an inner catheter having a proximal end and a distal end and extending through said introducer, wherein a distal end of said ablation valve is coupled to said distal end of said inner catheter, and said inner catheter and introducer are longitudinally translatable relative to each other to move said ablation valve between said open and closed configurations. 16. A neuromodulation device according to claim 1, further comprising: said RF generator electrically coupled to said terminal. 17. A neuromodulation device for use in a vessel having an endothelium and carrying body fluid with a fluid pressure, comprising: a) an elongate flexible introducer having a proximal end and distal end;b) an expandable ablation valve at said distal end of said introducer, said ablation valve having a first surface, an opposing second surface, a circumference, and a plurality of electrodes displaced about said circumference, said ablation valve adapted to dynamically react to fluid pressure within the vessel such that, i) when a pressure within and on said second surface of said ablation valve is less than the fluid pressure on said first surface of said ablation valve, said ablation valve is in a retreated configuration in which said electrodes are configured to be out of circumferential contact with the endothelium of the vessel, andii) when said pressure within and on said second surface of said ablation valve is greater than the fluid pressure on said first surface of said ablation valve, said ablation valve is in a contact configuration in which said electrodes are configured to be in circumferential contact with the endothelium of the vessel; andc) a conductor extending along said introducer, said conductor having a distal end electrically coupled to said electrodes of said ablation valve and a proximal end extended to a terminal for coupling to a RF generator.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (119)
Kletschka,Harold D.; Packard,Brian, Angioplasty device and method of making same.
Barbut, Denise; Pastrone, Giovanni; Maahs, Tracy D.; Tsugita, Ross S., Aortic occluder with associated filter and methods of use during cardiac surgery.
Barbut, Denise; Root, Jonathan D.; Pastrone, Giovanni; Maahs, Tracy D.; Tsugita, Ross S., Aortic occluder with associated filter and methods of use during cardiac surgery.
Barbut,Denise; Root,Jonathan D.; Pastrone,Giovanni; Maahs,Tracy D.; Tsugita,Ross S., Aortic occluder with associated filter and methods of use during cardiac surgery.
Barbut Denise ; Root Jonathan D ; Rizzari Robert ; Sellers James M ; Pastrone Giovanni ; McKenzie John, Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries.
Barbut Denise ; Root Jonathan D ; Rizzari Robert ; Sellers James M ; Pastrone Giovanni ; McKenzie John, Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries.
Barbut Denise R. ; Root Jonathan D. ; Pastrone Giovanni, Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries.
VanTassel, Robert A.; Hauser, Robert G.; Schwartz, Robert; Holmes, David; Sutton, Gregg S.; Borillo, Thomas E.; Welch, Jeffrey, Barrier device for covering the ostium of left atrial appendage.
Boyle, William J.; Huter, Benjamin C.; Peterson, Charles R.; Schwarten, Donald E.; Stack, Richard S., Deployment and recovery control systems for embolic protection devices.
Barbut, Denise R., Devices and methods for preventing distal embolization using flow reversal and perfusion augmentation within the cerebral vasculature.
Boylan, John F.; Boyle, William J.; Denison, Andy E.; Dutta, Debashis; Huter, Benjamin C.; Huter, Scott J.; Muller, Paul F.; Patel, Samir; Tarapata, Christopher J.; Wang, Chicheng; Sanchez, Francisco, Embolic protection devices.
Boyle, William J.; Burkett, David H.; Denison, Andy E.; Huter, Benjamin C.; Huter, Scott J.; Kokish, Arkady; Stalker, Kent C. B.; Wang, Chicheng; Whitfield, John D., Embolic protection devices.
Boyle, William J.; Denison, Andy E.; Huter, Benjamin C.; Huter, Scott J.; Stack, Richard S.; Stalker, Kent C. B.; Tarapata, Christopher; Whitfield, John D., Embolic protection devices.
Matthew J. Gillick ; Scott J. Huter ; Kent C. B. Stalker ; Benjamin C. Huter ; Anuja Patel, Embolic protection system and method including filtering elements.
VanTassel, Robert A.; Hauser, Robert G.; Schwartz, Robert; Holmes, David; Sutton, Gregg S.; Borillo, Thomas E.; Welch, Jeffrey, Filter apparatus for ostium of left atrial appendage.
VanTassel, Robert A.; Hauser, Robert G.; Schwartz, Robert; Holmes, David; Sutton, Gregg S.; Borillo, Thomas E.; Welch, Jeffrey, Filter apparatus for ostium of left atrial appendage.
Waksman Ron ; Weldon Thomas D. ; Meloul Raphael F. ; Hillstead Richard A. ; Rosen Jonathan J. ; Bonnoitt ; Jr. George K. ; Halpern David S. ; Larsen Charles E. ; Crocker Ian R., Method and apparatus for radiation treatment of a desired area in the vascular system of a patient.
Demarais, Denise; Clark, Benjamin J.; Zadno, Nicolas; Thai, Erik; Gifford, III, Hanson, Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach.
Deem, Mark; Gifford, III, Hanson; Demarais, Denise; Sutton, Douglas; Thai, Erik; Gelfand, Mark; Levin, Howard R., Methods and apparatus for renal neuromodulation.
Chomas, James E.; Pinchuk, Leonard; Martin, John; Arepally, Aravind; Naglreiter, Brett E.; Weldon, Norman R.; Pinchuk, Bryan M., Microvalve protection device and method of use for protection against embolization agent reflux.
Chomas, James E.; Pinchuk, Leonard; Martin, John; Arepally, Aravind; Naglreiter, Brett E.; Weldon, Norman R.; Pinchuk, Bryan M., Microvalve protection device and method of use for protection against embolization agent reflux.
Fogarty Thomas J. (Portola Valley CA) Hermann George D. (Los Gatos CA) Chin Albert K. (Palo Alto CA), Variable diameter sheath method and apparatus for use in body passages.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.