Methods of treating psoriasis using allantoin
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/4166
A61K-009/00
A61K-009/06
출원번호
US-0062295
(2013-10-24)
등록번호
US-9095574
(2015-08-04)
발명자
/ 주소
Farber, Elliott
Ryan, Robert
출원인 / 주소
Scioderm, Inc.
대리인 / 주소
Sterne, Kessler, Goldstein & Fox P.L.L.C.
인용정보
피인용 횟수 :
1인용 특허 :
87
초록▼
Embodiments herein provide formulations and methods for treatment of inflammatory skin diseases using allantoin in an amount from about 0.5% to about 15.0% by weight. Inflammatory skin diseases treated by embodiments herein include, without limitation, cutaneous porphyria, sclerodema, epidermolysis
Embodiments herein provide formulations and methods for treatment of inflammatory skin diseases using allantoin in an amount from about 0.5% to about 15.0% by weight. Inflammatory skin diseases treated by embodiments herein include, without limitation, cutaneous porphyria, sclerodema, epidermolysis bulosa, psoriasis, decubitus ulcers, pressure ulcers, diabetic ulcers, venous stasis ulcers, sickle cell ulcers, ulcers caused by burns, eczema, urticaria, atopic dermatitis, dermatitis herpetiform, contact dermatitis, arthritis, gout, lupus erythematosus, acne, alopecia, carcinomas, psoriasis, rosacea, miliaria, skin infections, post-operative care of incisions, post-operative skin care following any variety of plastic surgery operations, skin care following radiation treatment, care of dry, cracked or aged skin and skin lines as well as other conditions affecting the skin and having an inflammatory component, symptoms thereof, or a combination thereof. Symptoms treated may include pain, inflammation, redness, itching, scarring, skin thickening, milia, or a combination thereof.
대표청구항▼
1. A method for treating or reducing reoccurrence of psoriasis in a patient in need thereof comprising contacting the patient's skin with an effective amount of a composition comprising allantoin in an amount from about 3.0% to about 15% by weight; an emollient; an emulsifier; citric acid; propylene
1. A method for treating or reducing reoccurrence of psoriasis in a patient in need thereof comprising contacting the patient's skin with an effective amount of a composition comprising allantoin in an amount from about 3.0% to about 15% by weight; an emollient; an emulsifier; citric acid; propylene glycol; butylated hydroxytoluene (BHT); a preservative which is selected from the group consisting of methylparaben, propylparaben, and a combination thereof; tetrasodium EDTA; a viscosity enhancing agent which is selected from the group consisting of cetyl alcohol, stearyl alcohol, and a combination thereof; and water, wherein the composition is an oil-in-water emulsion and does not contain coal tar. 2. The method of claim 1, wherein the composition is administered to the subject daily. 3. The method of claim 1, wherein the allantoin is in an amount of about 3.0% to about 9.0%. 4. The method of claim 1, wherein the composition results in penetration of the allantoin across the skin membrane of the patient in a dose dependent manner. 5. The method of claim 1, wherein the composition results in penetration of the allantoin across the skin membrane of the patient without an increase in systemic blood levels of allantoin in the patient. 6. The method of claim 1, wherein the emollient is selected from the group consisting of lanolin oil, cod liver oil, mineral oil, an alcohol, and any combination thereof. 7. The method of claim 1, wherein the emulsifier is selected from the group consisting of sodium lauryl sulfate, a white wax, and a combination thereof. 8. The method of claim 1, wherein the pH of the composition is about 4.0 to about 5.5 at room temperature. 9. A method for reducing or clearing psoriatic plaques in a patient in need thereof comprising contacting the plaques with an effective amount of a composition comprising allantoin in an amount from about 3.0% to about 15% by weight; an emollient; an emulsifier; citric acid; propylene glycol; butylated hydroxytoluene (BHT); a preservative which is selected from the group consisting of methylparaben, propylparaben, and a combination thereof; tetrasodium EDTA; a viscosity enhancing agent which is selected from the group consisting of cetyl alcohol, stearyl alcohol, and a combination thereof; and water, wherein the composition is an oil-in-water emulsion and does not contain coal tar. 10. The method of claim 9, wherein the composition is administered to the subject daily. 11. The method of claim 9, wherein the allantoin is in an amount of about 3.0% to about 9.0%. 12. The method of claim 9, wherein the composition results in penetration of the allantoin across the skin membrane of the patient in a dose dependent manner. 13. The method of claim 9, wherein the composition results in penetration of the allantoin across the skin membrane of the patient without an increase in systemic blood levels of allantoin in the patient. 14. The method of claim 9, wherein the emollient is selected from the group consisting of lanolin oil, cod liver oil, mineral oil, an alcohol, and any combination thereof. 15. The method of claim 9, wherein the emulsifier is selected from the group consisting of sodium lauryl sulfate, a white wax, and a combination thereof. 16. The method of claim 9, wherein the pH of the composition is about 4.0 to about 5.5 at room temperature.
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이 특허에 인용된 특허 (87)
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