최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
---|---|
국제특허분류(IPC7판) |
|
출원번호 | US-0701265 (2003-11-04) |
등록번호 | US-9096636 (2015-08-04) |
발명자 / 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 | 피인용 횟수 : 0 인용 특허 : 400 |
Oligomer compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capble of hybridizing to a selected tar
Oligomer compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capble of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes at least one nucleotide comprising a chimeric organic composition. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide comprising a chimeric organic composition.
1. A composition comprising a duplex consisting of a first chemically synthesized oligonucleotide and a second chemically synthesized oligonucleotide, wherein: each of the first chemically synthesized oligonucleotide and the second chemically synthesized oligonucleotide independently consists of 17
1. A composition comprising a duplex consisting of a first chemically synthesized oligonucleotide and a second chemically synthesized oligonucleotide, wherein: each of the first chemically synthesized oligonucleotide and the second chemically synthesized oligonucleotide independently consists of 17 to 25 linked nucleosides, each nucleoside comprising a nucleobase and a sugar;the first chemically synthesized oligonucleotide is 100% complementary to the second chemically synthesized oligonucleotide and to a target mRNA;the first chemically synthesized oligonucleotide and the second chemically synthesized oligonucleotide are not covalently linked to each other; andthe first chemically synthesized oligonucleotide is a gapmer, wherein the gap comprises at least 4 nucleosides, each comprising a 2′-hydroxy-pentofuranosyl sugar moiety, and wherein each nucleoside of each wing comprises a 2′-sugar modification; andthe second chemically synthesized oligonucleotide comprises at least one nucleoside that comprises a 2′-sugar modification. 2. The composition of claim 1, wherein the second chemically synthesized oligonucleotide is a gapmer, wherein the gap comprises at least 4 nucleosides, each comprising a 2′-hydroxyl pentofuranosyl sugar moiety, and wherein each nucleoside of each wing comprises a 2′ modification. 3. The composition of claim 1, wherein each nucleoside of at least one of the wings of the gapmer comprises a 2′ sugar modification selected from fluoro, alkoxy, amino-alkoxy, allyloxy, imidazolylalkoxy, and methoxyethoxy. 4. The composition of claim 1, wherein each nucleoside of the 3′ wing of the gapmer comprises a 2′-OCH3. 5. The composition of claim 1, wherein each wing of the gapmer is from two to seven nucleosides in length. 6. The composition of claim 1, wherein at least one of the first chemically synthesized oligonucleotide and the second chemically synthesized oligonucleotide comprises at least one phosphorothioate linkage. 7. The composition of claim 6, wherein each of the first chemically synthesized oligonucleotide and the second chemically synthesized oligonucleotide comprises at least one phosphorothioate linkage.
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.