Compositions and methods of preparation thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12N-009/74
C12N-005/078
A61K-035/16
A61K-035/19
A61K-035/14
C07K-014/745
출원번호
US-0796045
(2007-04-26)
등록번호
US-9096839
(2015-08-04)
발명자
/ 주소
Kanayinkal, Tessy
Yonce, Laura A.
Mullins-Hirte, Debra
Huang, Trevor C.
Cariappa, Rohit
Merte, Kenneth E.
Keogh, James R.
McIntosh, Kevin D.
Steffens, Brian J.
Nayak, Asha S.
Johnson, Erick L.
출원인 / 주소
Arteriocyte Medical Systems, Inc.
대리인 / 주소
Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
인용정보
피인용 횟수 :
0인용 특허 :
45
초록
The present invention provides biological compositions and methods for making the same.
대표청구항▼
1. A method of preparing a fibrin composition, the method consisting of: contacting a first portion of an anticoagulated whole blood, a fraction of the anticoagulated whole blood, or a component of the anticoagulated whole blood with a contact activation agent and an extrinsic coagulation pathway in
1. A method of preparing a fibrin composition, the method consisting of: contacting a first portion of an anticoagulated whole blood, a fraction of the anticoagulated whole blood, or a component of the anticoagulated whole blood with a contact activation agent and an extrinsic coagulation pathway initiation agent to provide a coagulated mass in less than about 30 minutes;extracting thrombin from the coagulated mass to provide a thrombin composition;fractionating a second portion of the anticoagulated whole blood, the fraction of the anticoagulated whole blood, or the component of the anticoagulated whole blood to obtain a fibrinogen composition and a platelet plasma composition;contacting the fibrinogen composition, platelet plasma composition, or a combination thereof with a recombinant protein composition;contacting the thrombin composition with a stabilizing agent to provide a thrombin composition having a table-life of more than about 6 hours, wherein the anticoagulated whole blood, a fraction thereof or a component thereof is not contacted with the stabilizing agent during the generation of the coagulated mass;contacting the thrombin composition, the fibrinogen composition and the platelet plasma composition to generate a fibrin composition; andadding at least one micro-particle to the fibrin composition, wherein the at least one micro-particle includes at least one of the following: a pharmaceutical agent, a therapeutic agent, a medical agent, a biological agent, and any combination thereof;adding at least one protecting group to protect one or more functional groups of at least one of the following: the thrombin composition, the fibrinogen composition, the platelet plasma composition, and the fibrin composition, wherein the protecting group includes at least one of the following: a carbonyl protecting group, an alcohol protecting group, and an amine protecting group. 2. The method of claim 1, wherein the stabilizing agent comprises a polyol, PEG, ammonium sulfate, a non-polar solvent, a polar solvent, a methyl isobutyl ketone alcohol, glycol, tricloroacetic acid, acetate salt, or any combination thereof. 3. The method of claim 2, wherein the stabilizing agent comprises ethanol. 4. The method of claim 3, wherein about 8% to about 25% volume/volume ethanol is added to the thrombin composition. 5. The method of claim 4, wherein about 10% volume/volume ethanol is added to the thrombin composition. 6. The method of claim 1, wherein the thrombin composition has a table-life of more than 12 hours. 7. The method of claim 6, wherein the thrombin composition has a table-life of from more than 12 up to 24 hours. 8. The method of claim 1, wherein the coagulated mass is generated in less than about 10 minutes. 9. The method of claim 8, wherein the coagulated mass is generated in less than about 5 minutes. 10. The method of claim 9, wherein the coagulated mass is generated in less than about 3 minutes. 11. The method of claim 10, wherein the coagulated mass is generated in about 1 minute to about 3 minutes. 12. The method of claim 1, wherein the first portion is a portion of the anticoagulated whole blood, a portion of the fraction of the anticoagulated whole blood or a portion of the component of the anticoagulated whole blood and comprises platelet rich plasma (PRP), platelet poor plasma (PPP), or a combination thereof. 13. The method of claim 12, wherein the first portion is a portion of the anticoagulated whole blood, a portion of the fraction of the anticoagulated whole blood or a portion of the component of the anticoagulated whole blood and comprises platelet rich plasma (PRP). 14. The method of claim 12, wherein the first portion is a portion of the anticoagulated whole blood, a portion of the fraction of the anticoagulated whole blood or a portion of the component of the anticoagulated whole blood and comprises platelet poor plasma (PPP). 15. The method of claim 1, wherein the second portion is a portion of the anticoagulated whole blood, a portion of the fraction of the anticoagulated whole blood or a portion of the component of the anticoagulated whole blood and comprises platelet rich plasma (PRP), platelet poor plasma (PPP), or a combination thereof. 16. The method of claim 15, wherein the second portion is a portion of the anticoagulated whole blood, a portion of the fraction of the anticoagulated whole blood or a portion of the component of the anticoagulated whole blood and comprises platelet rich plasma (PRP).
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