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Method of determining the nucleotide sequence of oligonucleotides and DNA molecules

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
  • C12P-019/34
  • C07H-021/02
출원번호 US-0969872 (2010-12-16)
등록번호 US-9096898 (2015-08-04)
발명자 / 주소
  • Williams, Peter
  • Taylor, Thomas J.
  • Williams, Daniel J. B.
  • Gould, Ian
  • Hayes, Mark A.
출원인 / 주소
  • LIFE TECHNOLOGIES CORPORATION
인용정보 피인용 횟수 : 12  인용 특허 : 348

초록

The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template syst

대표청구항

1. A method of analyzing a nucleic acid molecule, the method comprising: (a) providing a template/primer duplex;(b) contacting the duplex with a single type of unlabeled and unblocked deoxyribonucleotide in the presence of a polymerase under conditions that allow extension of the primer by incorpora

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