Apparatus for testing electrical activity from a biological tissue sample
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12M-001/34
B01L-009/00
F28F-007/00
G01N-033/483
출원번호
US-0129059
(2009-11-12)
등록번호
US-9103815
(2015-08-11)
국제출원번호
PCT/NZ2009/000250
(2009-11-12)
§371/§102 date
20110512
(20110512)
국제공개번호
WO2010/056136
(2010-05-20)
발명자
/ 주소
Lovegrove, David
Kerr, Douglas Steven
Haughey, David James
Ronayne, Michael Paul
Best, Darryl John
출원인 / 주소
Kerr Scientific Instruments Limited
대리인 / 주소
Nelson Mullins Riley & Scarborough LLP
인용정보
피인용 횟수 :
0인용 특허 :
2
초록▼
An apparatus (100) for testing electrical activity from a biological tissue sample comprises a body (1) provided with a well (4), stimulating means (8) for stimulating a sample located in the well (4), and detecting means (9) for detecting electrical activity in the sample. In one embodiment the app
An apparatus (100) for testing electrical activity from a biological tissue sample comprises a body (1) provided with a well (4), stimulating means (8) for stimulating a sample located in the well (4), and detecting means (9) for detecting electrical activity in the sample. In one embodiment the apparatus has a fluid inlet means (10) and a fluid outlet means (16) in fluid communication with the well (4). The inlet means (10) comprises an electrically conductive conduit (11A) which is in fluid contact with a fluid flowing, in use, though the outlet means (16). In some embodiments the apparatus is provided with an electrically conductive member (19) which is in electrical contact with a fluid contained, in use, in at least one of the well (4), inlet means (10) and outlet means (16). The stimulating means (8) and detecting means (9) are engaged with the body (1) by a gripping means (32) which comprises an electrically conductive gripping member (36). Related methods and apparatus are also disclosed.
대표청구항▼
1. An apparatus for testing electrical activity from a biological tissue sample, the apparatus comprising a body provided with a well, the apparatus further comprising stimulating means for stimulating a biological tissue sample which is located, in use, in the well, and detecting means for detectin
1. An apparatus for testing electrical activity from a biological tissue sample, the apparatus comprising a body provided with a well, the apparatus further comprising stimulating means for stimulating a biological tissue sample which is located, in use, in the well, and detecting means for detecting electrical activity in the tissue sample, the apparatus further comprising a fluid inlet means in fluid communication with the well and a fluid outlet means in fluid communication with the well, wherein the inlet means comprises an electrically conductive conduit and the outlet means comprises an outlet passage provided in the body, and wherein the electrically conductive conduit of the fluid inlet means extends through a portion of the outlet passage and is in fluid contact with a fluid flowing, in use, through the outlet passage. 2. The apparatus of claim 1 wherein the body is provided with an electrically conductive member which is electrically connectable to the electrically conductive conduit. 3. The apparatus of claim 1 wherein the electrically conductive conduit has an electrical resistivity of less than 1×10−6 Ωm at room temperature. 4. The apparatus of claim 1 wherein the electrically conductive conduit has a thermal conductivity of at least 10 W/m K at room temperature. 5. The apparatus of claim 4 wherein the fluid outlet means comprises a passage adapted to receive a heating element such that the heating element is in thermal contact with fluid flowing though the outlet conduit upstream of the electrically conductive conduit, to thereby transfer heat to the fluid in the inlet means through the electrically conductive conduit. 6. An apparatus for testing electrical activity from a biological tissue sample, the apparatus comprising a body provided with a well, stimulating means for stimulating a biological tissue sample located, in use, in the well, and detecting means for detecting electrical activity in the tissue sample, a fluid inlet means in fluid communication with the well and a fluid outlet means in fluid communication with the well, wherein the fluid inlet means comprises an electrically conductive conduit and the fluid outlet means comprises an outlet passage provided in the body wherein the electrically conductive conduit of the fluid inlet means extends through a portion of the outlet passage and is in fluid contact with a fluid flowing, in use, through the outlet passage, the apparatus further comprising an electrically conductive member in electrical contact with the fluid contained, in use, in at least one of the well, the inlet means and the outlet means, wherein at least one of the stimulating means and detecting means is engaged with the body by a gripping means which comprises an electrically conductive gripping member which engages the electrically conductive member, and the electrically conductive gripping member is electrically connectable to a data recording system which, in use, records the electrical activity from the sample. 7. The apparatus of claim 6 wherein the electrically conductive member comprises an annular ring. 8. The apparatus of claim 7 wherein the annular ring is set into the body. 9. The apparatus of claim 7 wherein the electrically conductive gripping member exerts a force on an inner surface of the annular ring in a radially outward direction. 10. An apparatus for testing electrical activity from a biological tissue sample, the apparatus comprising a body provided with a well, the apparatus further comprising stimulating means for stimulating a biological tissue sample which is located, in use, in the well, and detecting means for detecting electrical activity in the tissue sample, the body provided with a fluid inlet means in fluid communication with the well and outlet means comprising an upwardly open outlet port in fluid communication with the well, and adjustable fluid level regulation means adapted to draw fluid, in use, from the upwardly open outlet port at a required level, the outlet means comprising an outlet passage provided in the body and an outlet aperture which is substantially fixed in position relative to the body, and further wherein the fluid inlet means comprises an electrically conductive conduit which extends through a portion of the outlet passage and is in fluid contact with a fluid flowing, in use, through the outlet passage.
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이 특허에 인용된 특허 (2)
Farb David H. ; Yaghoubi Nader ; Gibbs Terrell T., Cellular physiology workstations for automated data acquisition and perfusion control.
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