초록 ▼

Devices such as orthopedic implants are composed of a thermoplastic resin such as polyaryletheretherketone (PEEK), and include a ceramic species, such as a zeolite, to enhance its hydrophilic properties. The ceramic species can be a surface coating, can be incorporated or embedded into the thermopla

Devices such as orthopedic implants are composed of a thermoplastic resin such as polyaryletheretherketone (PEEK), and include a ceramic species, such as a zeolite, to enhance its hydrophilic properties. The ceramic species can be a surface coating, can be incorporated or embedded into the thermoplastic resin, or can be both a surface coating and incorporated or embedded into the resin. In certain embodiments, the ceramic species is zeolite that is incorporated into the device, especially at the exposed surface of the device, and is devoid of antimicrobial metal ions. The device is introduced into the body surgically.

대표청구항 ▼

1. A medical implant having an exposed surface, said implant comprising a thermoplastic resin having aluminosilicate particles incorporated therein, said aluminosilicate particles being devoid of antimicrobial metal ions and being present in said resin in an amount sufficient to impart a negative ch

1. A medical implant having an exposed surface, said implant comprising a thermoplastic resin having aluminosilicate particles incorporated therein, said aluminosilicate particles being devoid of antimicrobial metal ions and being present in said resin in an amount sufficient to impart a negative charge to said exposed surface of said implant. 2. The implant of claim 1, where said implant is an interbody spinal cage. 3. The implant of claim 1, wherein said thermoplastic resin comprises PEEK. 4. The implant of claim 1, wherein said aluminosilicate is represented by the formula XM2/nO.Al2O3.YsiO2.ZH2O wherein M represents an ion-exchangeable ion, n represents the atomic valency of the (metal) ion, X and Y represent coefficients of metal oxide and silica respectively, and Z represents the number of water of crystallization. 5. A method of minimizing biofilm formation in a patient, comprising implanting in said patient a device having an exposed surface, said device comprising a thermoplastic resin having aluminosilicate particles incorporated therein, said aluminosilicate particles being devoid of antimicrobial metal ions and being present in said resin in an amount sufficient to impart a negative charge to said exposed surface of said device. 6. The method of claim 5, wherein said aluminosilicate is represented by the formula XM2/nO.Al2O3.YsiO2.ZH2O wherein M represents an ion-exchangeable ion, n represents the atomic valency of the (metal) ion, X and Y represent coefficients of metal oxide and silica respectively, and Z represents the number of water of crystallization. 7. A medical implant having an exposed surface, said implant comprising a thermoplastic resin having aluminosilicate particles incorporated therein, said aluminosilicate particles being devoid of antimicrobial metal ions, wherein said aluminosilicate particles are present in an amount effective for rendering said exposed surface hydrophilic. 8. The implant of claim 7, wherein said thermoplastic resin comprises PEEK. 9. The implant of claim 7, wherein said implant is an interbody spinal cage. 10. The implant of claim 7, wherein said aluminosilicate is represented by the formula XM2/nO.Al2O3.YsiO2.ZH2O wherein M represents an ion-exchangeable ion, n represents the atomic valency of the (metal) ion, X and Y represent coefficients of metal oxide and silica respectively, and Z represents the number of water of crystallization.