Injectable hydrogel filaments for biomedical uses
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/00
A61F-013/00
A61L-031/18
A61L-031/16
A61L-031/06
A61L-031/14
출원번호
US-0890540
(2010-09-24)
등록번호
US-9114200
(2015-08-25)
발명자
/ 주소
Constant, Michael J.
Cruise, Gregory M.
Keeley, E. Michael
Berenstein, Alejandro
출원인 / 주소
MicroVention, Inc.
대리인 / 주소
K&L Gates LLP
인용정보
피인용 횟수 :
0인용 특허 :
119
초록▼
Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations with radiopaque hydrogel filaments with delayed controlled rates of expansion permitting the repositioning of the device once inside the structure or malformation. Further described i
Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations with radiopaque hydrogel filaments with delayed controlled rates of expansion permitting the repositioning of the device once inside the structure or malformation. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.
대표청구항▼
1. A device for implantation comprising: a filament including about 30% of a difunctional, low molecular weight ethylenically unsaturated shapeable poly(tetramethylene oxide) macromer; a first ethylenically unsaturated monomer, wherein said first monomer is ionizable; a second ethylenically unsatura
1. A device for implantation comprising: a filament including about 30% of a difunctional, low molecular weight ethylenically unsaturated shapeable poly(tetramethylene oxide) macromer; a first ethylenically unsaturated monomer, wherein said first monomer is ionizable; a second ethylenically unsaturated monomer; and a visualization agent,wherein said device contains no support members and said filament has a bending resistance between about 0.5 mg and 0.1 mg. 2. The device according to claim 1 wherein said macromer has a molecular weight of about 100 grams/mole to about 5000 grams/mole. 3. The device according to claim 1 wherein said filament is environmentally-responsive. 4. The device according to claim 1 wherein said macromer comprises poly(tetramethylene oxide) diacrylate. 5. The device according to claim 1 wherein said first ethylenically unsaturated monomer comprises one or more ionizable functional groups. 6. The device according to claim 1 wherein said second ethylenically unsaturated monomer comprises N,N′-methylenebisacrylamide, N-vinyl pyrrolidinone, 2-hydroxyethyl methacrylate, derivatives thereof, or combinations thereof. 7. The device according to claim 1 wherein said macromer, said first monomer, and said second monomer are crosslinked with N,N,N′,N′-tetramethylethylenediamine, ammonium persulfate, azobisisobutyronitrile, benzoyl peroxides, 2,2′-azobis(2-methylpropionamidine) dihydrochloride, derivatives thereof, or combinations thereof. 8. The device according to claim 1 wherein said visualization agent comprises 48.6% w/w barium sulfate. 9. The device according to claim 1 wherein said visualization agent comprises 45.1% w/w barium sulfate. 10. The device according to claim 1 wherein said visualization agent comprises 59% barium sulfate after drying. 11. The device according to claim 1 comprising about 7% hydroxyethyl methacrylate, about 3% acrylic acid, about 1% bisacrylamide, and about 59% barium sulfate after drying. 12. The device according to claim 1 wherein said visualization agent comprises 56% barium sulfate after drying. 13. The device according to claim 1 comprising about 8% hydroxyethyl methacrylate, about 3% acrylic acid, and about 56% barium sulfate after drying. 14. The device according to claim 1 wherein said visualization agent comprises gadolinium or iron oxide. 15. The device according to claim 1 wherein said visualization element comprise barium. 16. The device according to claim 7 wherein said cross-linker comprises N,N′-methylenebisacrylamide. 17. The device according to claim 5 wherein said ionizable functional groups comprise basic groups or acidic groups. 18. The device according to claim 17 wherein said basic groups comprise amine groups, derivatives thereof, or combinations thereof. 19. The device according to claim 17 wherein said acidic groups comprise a carboxylic acid, derivatives thereof, or combinations thereof. 20. The device according to claim 1 wherein said filament is substantially free of acrylamide. 21. The device according to claim 1 wherein said filament is substantially non-bioresorbable. 22. The device according to claim 1 wherein said filament is bioresorbable. 23. A device for implantation comprising: a filament including about 33% of a difunctional, low molecular weight ethylenically unsaturated shapeable poly(tetramethylene oxide) macromer; a first ethylenically unsaturated monomer, wherein said first monomer is ionizable; a second ethylenically unsaturated monomer; and a visualization agent,wherein said device contains no support members and said filament has a bending resistance between about 0.5 mg and 0.1 mg. 24. The device according to claim 23 wherein said macromer has a molecular weight of about 100 grams/mole to about 5000 grams/mole. 25. The device according to claim 23 wherein said filament is environmentally-responsive. 26. The device according to claim 23 wherein said macromer comprises poly(tetramethylene oxide) diacrylate. 27. The device according to claim 23 wherein said first ethylenically unsaturated monomer comprises one or more ionizable functional groups. 28. The device according to claim 23 wherein said second ethylenically unsaturated monomer comprises N,N′-methylenebisacrylamide, N-vinyl pyrrolidinone, 2-hydroxyethyl methacrylate, derivatives thereof, or combinations thereof. 29. The device according to claim 23 wherein said visualization agent comprises 48.6% w/w barium sulfate. 30. The device according to claim 23 wherein said visualization agent comprises 45.1% w/w barium sulfate. 31. The device according to claim 23 wherein said visualization agent comprises 59% barium sulfate after drying. 32. The device according to claim 23 comprising about 7% hydroxyethyl methacrylate, about 3% acrylic acid, about 1% bisacrylamide, and about 59% barium sulfate after drying. 33. The device according to claim 23 wherein said visualization agent comprises 56% barium sulfate after drying. 34. The device according to claim 23 comprising about 8% hydroxyethyl methacrylate, about 3% acrylic acid, and about 56% barium sulfate after drying. 35. The device according to claim 23 wherein said visualization agent comprises gadolinium or iron oxide. 36. The device according to claim 23 wherein said visualization element comprises barium. 37. The device according to claim 23 wherein said macromer, said first monomer, and said second monomer are crosslinked with N,N,N′,N′-tetramethylethylenediamine, ammonium persulfate, azobisisobutyronitrile, benzoyl peroxides, 2,2′-azobis(2-methylpropionamidine) dihydrochloride, derivatives thereof, or combinations thereof. 38. The device according to claim 37 wherein said cross-linker comprises N,N′-methylenebisacrylamide. 39. The device according to claim 27 wherein said ionizable functional groups comprise basic groups or acidic groups. 40. The device according to claim 39 wherein said basic groups comprise amine groups, derivatives thereof, or combinations thereof. 41. The device according to claim 39 wherein said acidic groups comprise a carboxylic acid, derivatives thereof, or combinations thereof. 42. The device according to claim 23 wherein said filament is substantially free of acrylamide. 43. The device according to claim 23 wherein said filament is substantially non-bioresorbable. 44. The device according to claim 23 wherein said filament is bioresorbable.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (119)
Crowley Robert J. (Wayland MA) Couvillon ; Jr. Lucien A. (Concord MA) Abele John E. (Concord MA), Acoustic imaging catheter and the like.
Kupiecki David ; Teoh Clifford ; Doan Hong ; Gia Son M. ; Engelson Erik T. ; Chee Uriel Hiram ; Bashiri Mehran ; Eder Joseph C., Aneurysm closure device assembly.
Kupiecki David ; Teoh Clifford ; Doan Hong ; Gia Son M. ; Engelson Erik T. ; Chee Uriel Hiram ; Bashiri Mehran ; Eder Joseph C., Aneurysm closure device assembly.
Ron Eyal S. (Lexington MA) Schiller Matthew E. (Waltham MA) Roos Eric (Grafton MA), Apparatus and method for delivering a biologically active compound into a biological environment.
Rowe Stephen C. (Wellesley MA) Hubbell Jeffrey A. (San Marino CA) Herman Stephen J. (Andover MA) Sun Vae (Palo Alto CA) Lang Michael F. (North Andover MA) Selecman George E. (Marblehead MA) Ahari Fre, Apparatus and method for local application of polymeric material to tissue.
Greff Richard J. (Yorba Linda CA) Jones Michael L. (Capistrano Beach CA) Evans Scott (Santa Ana CA), Cellulose diacetate compositions for use in embolizing blood vessels.
Fearnot Neal E. (West Lafayette IN) Kozma Thomas G. (West Lafayette IN) Ragheb Anthony O. (West Lafayette IN) Voorhees William D. (West Lafayette IN), Coated implantable medical device.
Batich Christopher D. (Gainesville FL) Cohen Marc S. (Gainesville FL) Foster Kirk (Baltimore MD), Compositions and devices for controlled release of active ingredients.
Leshchiner Adolf (Fairview NJ) Larsen Nancy E. (Southfield NY) Balazs Endre A. (Ft. Lee NJ) Hilal Sadek K. (Englewood Cliffs NJ), Compositions for therapeutic percutaneous embolization and the use thereof.
Annan Nikoi ; Reynolds Charles Howard ; Shaber Steven Howard ; Langenmayr Eric Jon, Contrast enhancing agent having a polymeric core and polymeric shell.
Linden Bradley (Eden Prairie MN) Palme ; II Donald F. (Dayton MN) Buscemi Paul J. (Long Lake MN) Holman Thomas J. (Minneapolis MN), Device for closing a septal defect.
McGurk Erin (Palo Alto CA) Dieck Ronald (Palo Alto CA) Tremulis William S. (Redwood City CA), Embolic elements and methods and apparatus for their delivery.
Dormandy ; Jr. Ray (San Bruno CA) Berlo Marcelyn A. (San Francisco CA) Paul David J. (Pleasanton CA), Embolization device and apparatus including an introducer cartridge and a delivery catheter and method for delivering th.
Dormandy ; Jr. Ray H. (San Bruno CA) Berlo Marcelyn A. (San Francisco CA), Embolization device and apparatus including an introducer cartridge and method for delivering the same.
Conston Stanley R. (San Carlos CA) Dapper Gregory S. (Newark CA) Murphy Aileen L. (Menlo Park CA) Raeder-Devens Jennifer (Oakland CA) Yamamoto Ronald (San Francisco CA), Embolization plugs for blood vessels.
Guglielmi Guido (Los Angeles CA) Sepetka Ivan (Redwood City CA), Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysm.
Schwartz Robert S. (Rochester MN) Holmes David R. (Rochester MN) Halverson Frederick S. (North Oaks MN) Donadio ; III James V. (Chaska MN) Berry David (Longmont CO), Flexible tubular device for use in medical applications.
Takahashi Toru (Shizuoka-ken JPX) Nakamura Hideki (Kanagawa-ken JPX) Goto Katsuya (Fukuoka-ken JPX), High polymer gel and vascular lesion embolizing material comprising the same.
Fleischhacker Mark G. (Minnetonka MN) Fleischhacker ; Jr. Joseph F. (Mound MN) Hargreaves Thomas E. (Mound MN) Hanson Donald W. (Chanhassen MN), Hollow lumen cable apparatus.
Fleischhacker Mark G. (Minnetonka MN) Fleischhacker ; Jr. Joseph F. (Mound MN) Hargreaves Thomas E. (Mound MN) Hanson Donald W. (Chanhassen MN), Hollow lumen cable apparatus.
Cruise, Gregory M.; Constant, Michael J., Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use.
Crawford Lynn (27406 Diane Marie Cir. Saugus CA 91350) McArthur William A. (27544 Lovage Ct. Saugus CA 91350), Implantable electrode having different stiffening and curvature maintaining characteristics along its length.
Rhee Woonza M. ; Berg Richard A. ; Chu George H. ; DeLustro Frank A. ; Jolivette Dan M. ; McCullough Kimberly A., Injectable or implantable biomaterials for filling or blocking lumens and voids of the body.
Fleischhacker Mark G. (Minnetonka MN) Fleischhacker ; Jr. Joseph F. (Mound MN) Hargreaves Thomas E. (Mound MN) Hanson Donald W. (Chanhassen MN), Method of making a hollow lumen cable.
Stewart Ray F. (Redwood City CA) Greene Lawrence C. (Boulder Creek CA) Bhaskar Ravi K. (Lawrence KS), Microcapsule having temperature-dependent permeability profile.
Pathak Chandrashekhar P. ; Barman Shikha P. ; Philbrook C. Michael ; Sawhney Amarpreet S. ; Coury Arthur J. ; Avila Luis Z. ; Kieras Mark T., Multiblock biodegradable hydrogels for drug delivery and tissue treatment.
Pasztor, Emil; Lazar, Laszlo; Nagy, Jozsef; Pallosy nee Becker, Katalin, Pharmaceutically acceptable silicon rubber and therapeutical set and the use thereof for surgical embolization.
Hyon Suong-Hyu (Tamatsukurimotomachi JPX) Ikada Yoshito (Tamatsukurimotomachi JPX), Porous and transparent poly(vinyl alcohol) gel and method of manufacturing the same.
Willson James K. V. (P.O. Box 2144 Mobile AL 36601) Eskridge Marshall (P.O. Box 2144 Mobile AL 36601), Spring guide wire with torque control for catheterization of blood vessels and method of using same.
Dormandy ; Jr. Ray H. (South San Francisco CA) Bell Julie D. (South San Francisco CA), System for artificial vessel embolization and devices for use therewith.
Ferrera David A. ; Kurz Daniel R. ; Wilson Peter ; Sein-Lwyn Crystal K. ; Lei Lok A., Three dimensional, low friction vasoocclusive coil, and method of manufacture.
Ritchart Mark (Santa Clara CA) Mariant Mike (Santa Clara CA) Sepetka Ivan (Santa Clara CA) Engelson Erik (Portola Valley CA), Vaso-occlusion coil and method.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.