[특허]Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes

Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-031/711 A61K-009/14 A61K-031/7088 A61P-003/10 A61P-037/06 C12N-015/113 A61K-009/00 A61K-009/16 A61K-009/19 C12N-015/11
출원번호	US-0822774 (2010-06-24)
등록번호	US-9115357 (2015-08-25)
발명자 / 주소	Brown, Larry R. Bisker-Leib, Vered Scott, Terrence L. Lafreniere, Debra Machen, Jennifer Giannoukakis, Nick
출원인 / 주소	BAXTER INTERNATIONAL INC.
대리인 / 주소	Marshall, Gerstein & Borun LLP
인용정보	피인용 횟수 : 0 인용 특허 : 90

초록 ▼

AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.

대표청구항 ▼

1. A composition comprising microspheres, said microspheres comprising (a) polyvinyl pyrrolidone and polyethylene glycol, (b) a polycation, and (c) thiolated oligonucleotides including a first antisense sequence that targets CD40 primary transcript, a second antisense sequence that targets CD80 primary transcript, and a third antisense sequence that targets CD86 primary transcript, wherein each of said first, second and third oligonucleotides reduces or suppresses in vivo expression of CD40, CD80 and CD86, respectively, and wherein said oligonucleotides comprise greater than about 30 weight percent of the microspheres, based on total weight of the microspheres, said microspheres having an average particle size of at least 0.2 microns and not greater than about 50 microns, and said microspheres, when administered, treat type 1 diabetes. 2. The composition of claim 1, wherein the microspheres have an average particle size of 0.2 microns to 8 microns. 3. The composition of claim 1, wherein the microspheres have an average particle size of 0.5 microns to 4 microns. 4. The composition of claim 1, wherein the microspheres have an average particle size of about 2 microns. 5. The composition of claim 1, wherein the polycation is poly-L-lysine or poly-L-ornithine. 6. A method for protecting beta cells of the pancreas of an individual from autoimmune destruction associated with Type 1 diabetes, comprising administering to the individual the composition of claim 1 in an amount effective to protect beta cells from autoimmune destruction, thereby protecting beta cells of the pancreas of the individual from autoimmune destruction associated with Type 1 diabetes. 7. A method for treating Type 1 diabetes, comprising administering to an individual the composition of claim 1 in an amount effective to induce immune tolerance, thereby treating Type 1 diabetes in the individual. 8. The method of claim 7, wherein the composition is suitable for subcutaneous administration. 9. A method for preserving residual beta cell mass in an individual suffering from Type 1 diabetes, comprising administering to the subject the composition of claim 1 in an amount effective to preserve residual beta cell mass, thereby preserving residual beta cell mass in the subject.

이 특허에 인용된 특허 (90)

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연합인증

Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes 원문보기

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연합인증

Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes 원문보기

초록 ▼

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