The invention provides a polymeric medical sealant. The medical sealant is useful for application to the tonsils and adenoids, wherein the sealant performs at least one of the following functions, a) inhibit the colonization of bacteria, b) inhibit the binding of bacteria to tissue, c) reduction of
The invention provides a polymeric medical sealant. The medical sealant is useful for application to the tonsils and adenoids, wherein the sealant performs at least one of the following functions, a) inhibit the colonization of bacteria, b) inhibit the binding of bacteria to tissue, c) reduction of tissue morbidity, d) hemostasis, e) coating and protection of tissue during healing. f) promotion of healing, and g) reduction of pain.
대표청구항▼
1. A method of postoperative treatment for use after removal of the tonsils or adenoids which comprises the step of applying to throat tissue a powder which hardens and crosslinks after application to form a bioresorbable or biodegradable polymeric medical sealant that adheres to such tissue and per
1. A method of postoperative treatment for use after removal of the tonsils or adenoids which comprises the step of applying to throat tissue a powder which hardens and crosslinks after application to form a bioresorbable or biodegradable polymeric medical sealant that adheres to such tissue and performs at least one of the following functions: a) inhibits the colonization of bacteria, b) inhibits the binding of bacteria to tissue, c) reduces tissue morbidity, d) hemostasis, e) coats and protects tissue during healing, f) promotes healing, or g) reduces pain, wherein the powder comprises a silk, silk-elastin, poly(malic acid), polyhydroxybutyrate, polyhydroxyvalerate, chitin, chitosan, oxidized cellulose, or agar polymer, copolymer, terpolymer, blend or mixture thereof. 2. The method of treatment according to claim 1 wherein the application of the powder reduces pain in tissue to which it is applied during treatment or postoperative healing. 3. The method of treatment according to claim 1 wherein the powder further includes at least one therapeutic agent selected from the group consisting of analgesics, antihistamines, anti-infective agents, anti-fungal agents, biostatic compositions, anti-inflammatory agents, anticholingerics, antineoplastic agents, cytokines, decongestants, vitamins, peptides, proteins, nucleic acids, immunosuppressors, vasoconstrictors and mixtures thereof. 4. The method of treatment according to claim 1 wherein the powder has a colorant that provides visual confirmation of the sealant present at a surgical site. 5. The method of treatment according to claim 1 wherein the sealant inhibits the colonization of bacteria. 6. The method of treatment according to claim 1 wherein the sealant inhibits the binding of bacteria to tissue. 7. The method of treatment according to claim 1 wherein the powder reduces tissue morbidity in tissue to which it is applied. 8. The method of treatment according to claim 1 wherein the sealant reduces bleeding. 9. The method of treatment according to claim 1 wherein the sealant coats and protects tissue during healing. 10. The method of treatment according to claim 1 wherein the sealant promotes healing. 11. The method of treatment according to claim 1 wherein the sealant performs hemostasis, promotes healing and reduces pain. 12. The method of treatment according to claim 1 wherein the sealant is a crosslinked silk or silk-elastin polymer, or a copolymer, terpolymer, blend, or mixture thereof. 13. The method of treatment according to claim 1 wherein the sealant is a crosslinked chitosan polymer, or a copolymer, terpolymer, blend, or mixture thereof. 14. The method of treatment according to claim 1 wherein the powder comprises a crosslinking material. 15. The method of treatment according to claim 1 wherein the sealant is a polyhydroxybutyrate or polyhydroxyvalerate polymer, or a copolymer, terpolymer, blend, or mixture thereof. 16. The method of treatment according to claim 1 wherein the sealant is a chitin polymer, or a copolymer, terpolymer, blend, or mixture thereof. 17. The method of treatment according to claim 1 wherein the sealant is a poly(malic acid), or a copolymer, terpolymer, blend, or mixture thereof. 18. The method of treatment according to claim 1 comprising applying the powder in atomized form. 19. The method of treatment according to claim 1 wherein the powder forms a pliable barrier upon application. 20. The method of treatment according to claim 1 wherein the sealant is a viscoelastic material. 21. The method of treatment according to claim 1 wherein the sealant has a residence time of at least one day. 22. The method of treatment according to claim 1 wherein the sealant has a residence time of at least one week. 23. The method of treatment according to claim 1 wherein the sealant has a residence time of at least one month. 24. The method of treatment according to claim 1 wherein the sealant is an oxidized cellulose polymer, or a copolymer, terpolymer, blend, or mixture thereof. 25. The method of treatment according to claim 1 wherein the sealant is an agar polymer, or a copolymer, terpolymer, blend, or mixture thereof.
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