Systems, methods and compositions for optimizing tissue and cell enriched grafts
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12M-001/12
C12N-005/071
C12M-001/00
A61K-035/35
출원번호
US-0771985
(2010-04-30)
등록번호
US-9133431
(2015-09-15)
발명자
/ 주소
Peterson, Alvin
Fornace, Lucas
출원인 / 주소
BIMINI TECHNOLOGIES LLC
대리인 / 주소
DLA Piper LLP (US)
인용정보
피인용 횟수 :
2인용 특허 :
109
초록
Disclosed herein are methods and systems for the concentration of cells from a cell suspension into unprocessed tissue, such as adipose tissue. Also disclosed herein are systems for optimizing hydration of tissue and cell enriched grafts.
대표청구항▼
1. An adipose tissue processing device, comprising: a flexible, collapsible bag comprising a first outer shell and a second outer shell that are joined to form a bag, wherein the bag comprises: a first port in communication with a first subsystem, which receives adipose tissue and, which is defined
1. An adipose tissue processing device, comprising: a flexible, collapsible bag comprising a first outer shell and a second outer shell that are joined to form a bag, wherein the bag comprises: a first port in communication with a first subsystem, which receives adipose tissue and, which is defined by a first outer shell of the bag and a filter disposed within the bag, wherein the filter comprises a plurality of pores that pass liquids, tumescent fluids, red blood cells, and wash solutions and retain mature adipocytes, regenerative cells, stem cells, progenitor cells and connective tissue; anda second port in communication with a second subsystem, which is defined by the filter and the second outer shell of the bag,wherein the second subsystem further comprises a separator that creates a space between the filter and the second outer shell of the bag,wherein said separator comprises a separation screen or mesh that comprises pores that are larger than the pores in the filter,wherein the first subsystem and second subsystem are configured to store tissue or cell samples within the bag as the flexible, collapsible bag expands, wherein the pore size of said filter is between about 30 μm and about 200 μm, andwherein the separator comprises pores that comprise a pore size that is between about 300 and 2000 μm. 2. The adipose tissue processing device of claim 1, wherein the separator has a degree of freedom. 3. The adipose tissue processing device of claim 1, wherein the separator is free floating within said second subsystem. 4. The adipose tissue processing device of claim 1, wherein the separator comprises on or more ribs. 5. The adipose tissue processing device of claim 1, wherein the separator comprises on or more struts. 6. The adipose tissue processing device of claim 1, wherein the first outer shell and the second outer shell are joined by a double heat seal. 7. The adipose tissue processing device of claim 6, wherein the filter is joined to the first outer shell and the second outer shell by a double heat seal. 8. The adipose tissue processing device of claim 1, wherein said separator comprises a mesh. 9. The adipose tissue processing device of claim 1, wherein said separator comprises a screen. 10. The adipose tissue processing device of claim 1, wherein said first port is configured to releasably connect with an adapter, said adapter being configured to releasably connect with a syringe barrel. 11. The adipose tissue processing device of claim 10, wherein the first port is configured to allow material to enter into the first port, but not to exit from the first port. 12. The adipose tissue processing device of claim 11, wherein said first port comprises a deformable plastic valve. 13. The adipose tissue processing device of claim 10, wherein the syringe barrel is a 60 mL catheter syringe barrel. 14. The adipose tissue processing device of claim 1, wherein the first port is configured to be attached to a cannula, while maintaining a sterile fluid/tissue pathway. 15. The adipose tissue processing device of claim 1, further comprising a third port in communication with the first subsystem, which exists between the first outer shell of the bag and the filter disposed within the bag. 16. The adipose tissue processing device of claim 15, wherein said third port is connected to a Y connector. 17. A method of making an adipose tissue graft, comprising: (a) obtaining a first portion of unprocessed adipose tissue;(b) introducing said first portion of unprocessed adipose tissue into the first subsystem of a first device of claim 1,(c) rinsing the first portion of unprocessed adipose tissue by adding a physiologic wash solution to the first subsystem; and(d) removing fluid from the second subsystem of the first device, wherein the fluid is selected from the group consisting of water, physiologic wash solution, blood and free lipid, or any combination thereof, thereby dehydrating the adipose tissue. 18. The method of claim 17, wherein the physiologic wash solution is selected from the group consisting of Lactated Ringer's solution, Hartmann's Solution, and saline. 19. The method of claim 17, wherein said dehydrated adipose tissue has a liquid content that is less than about ½, ⅓, or ¼ times that of said first portion of unprocessed adipose tissue prior to the introducing step. 20. The method of claim 17, wherein said dehydrated adipose tissue has a liquid content that is less than about ⅓ that of said first portion of unprocessed adipose tissue prior to the introducing step.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (109)
Goldman Stephen A. (Cincinnati OH) Retzsch Herbert L. (Cincinnati OH) Mansfield Todd L. (Cincinnati OH), Absorbent members for body fluids having good wet integrity and relatively high concentrations of hydrogel-forming absor.
Katz, Adam J.; Llull, Ramon; Futrell, William J.; Hedrick, Marc H.; Benhaim, Prosper; Lorenz, Hermann Peter; Zhu, Min, Adipose-derived stem cells and lattices.
Giesler Richard ; Chapman John R. ; Ellis Dale R. ; Bischof Daniel F., Apparatus for separation of biologic components from heterogeneous cell populations.
Hedrick, Marc H.; Fraser, John K.; Schulzki, Michael J.; Byrnes, Bobby; Carlson, Grace; Schreiber, Ronda Elizabeth; Wulur, Isabella, Automated methods for isolating and using clinically safe adipose derived regenerative cells.
Wolinsky Harvey (New York NY) King Spencer L. (Atlanta GA) Barbere Michael D. (Dunstable MA), Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen.
Lindall Arnold W. (1150 Nordic Ave. North ; P.O. Box 187 Stillwater MN 55082), Catheter system for controllably releasing a therapeutic agent at a remote tissue site.
Dwulet Francis E. ; Smith Marilyn E., Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease.
Lake William C. (Laguna Niguel CA) Giesler Richard (Deerfield IL) Epps Dennis Van (Cary IL) Chapman John R. (Lake Villa IL) Martinson Jeffrey A. (Mundelein IL) Ellis Dale R. (Wonder Lake IL) Aono Fre, Continuous centrifugation process for the separation of biological components from heterogeneous cell populations.
Lake William C. ; Giesler Richard ; Van Epps Dennis ; Chapman John R. ; Martinson Jeffrey A. ; Ellis Dale R. ; Aono Frederick ; Bischof Daniel F., Continuous process for the separation of biologic components from heterogeneous cell populations.
Alchas Paul G. (29 Ponds Cir. Wayne NJ 07470) Prais Alfred W. (245 Awosting Rd. Hewitt NJ 07421) Jarrell Bruce E. (5700 N. Via Elena Tucson AZ 85718) Williams Stuart K. (5181 N. Circulo Sobrio Tucson, Device and method for collecting and processing fat tissue and procuring microvessel endothelial cells to produce endoth.
Alchas Paul G. (Wayne NJ) Augello Frank A. (Cedar Knolls NJ) Brooks Christopher J. (Glen Cove NY) Cutshall Tony A. (Boonton NJ) DiPisa ; Jr. Joseph A. (Wyckoff NJ) Williams Stuart K. (Wilmington DE) , Endothelial cell procurement and deposition kit.
Alchas, Paul G.; Augello, Frank A.; Brooks, Christopher J.; Cutshall, Tony A.; DiPisa, Jr., Joseph A.; Williams, Stuart K.; Gabel, Jonathan B.; Mulhauser, Paul J.; Prais, Wes; Jarrell, Bruce E.; Rose, Endothelial cell procurement and deposition kit.
Caplan Arnold I. ; Haynesworth Stephen E. ; Gerson Stanton L. ; Lazarus Hillard M., Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells.
Weiss Samuel,CAX ; Reynolds Brent,CAX ; Hammang Joseph P. ; Baetge E. Edward, In vitro growth and proliferation of multipotent neural stem cells and their progeny.
Peterson Dale R. ; Nousek-Goebl Nancy, Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration.
Dubrul Will R. (P.O. Box 1211 Santa Barbara CA 93103) Elliott Martin P. (250 Hazel Dr. Corona Del Mar CA 92625), Liposuction filter and lipoplasty device.
Sheng Ping Zhong ; Arthur R. Madenjian ; Douglas E. Godshall ; John M. Ronan ; Samuel A. Thompson, Medical devices comprising hydrogel polymers having improved mechanical properties.
Humes H. David (Ann Arbor MI) Cieslinski Deborah A. (Ann Arbor MI), Method and compositions of a bioartificial kidney suitable for use in vivo or ex vivo.
McNally Robert T. (Marietta GA) McCaa Cameron (Marietta GA) Brockbank Kelvin G. M. (Marietta GA) Heacox Albert E. (Marietta GA) Bank Harvey L. (Charleston SC), Method for cryopreserving blood vessels.
Eppley Barry L. (8360 Lakeshore Cir. Indianapolis IN 46250) Krukowski Marilyn D. (24 Washington Ter. St. Louis MO 63112) Osdoby Philip A. (16206 Berry Hollow Ct. Ballwin MO 63011), Method for promoting soft connective tissue growth and repair in mammals.
Caplan Arnold I. (1300 Oakridge Dr. Cleveland Heights OH 44121) Haynesworth Stephen E. (3643 Antisdale Rd. Cleveland Heights OH 44118), Method for treating connective tissue disorders.
Yannas Ioannis V. (Newton Center MA) Burke John F. (Belmont MA) Orgill Dennis P. (Cambridge MA) Skrabut Eugene M. (Beverly MA), Method of promoting the regeneration of tissue at a wound.
Carabasi R. Anthony (Bryn Mawr PA) Jarrell Bruce E. (Philadelphia PA) Williams Stuart K. (Wilmington DE), Method of reendothelializing vascular linings.
Williams Stuart K. (Wilmington DE) Jarrell Bruce E. (Philadelphia PA), Method of treating a synthetic naturally occurring surface with a collagen laminate to support microvascular endothelial.
Williams Stuart K. (Drexel Hill PA) Jarrell Bruce E. (Philadelphia PA), Method of treating a synthetic or naturally occuring surface with microvascular endothelial cells, and the treated surfa.
Lacy Paul E. (63 Marshall Pl. St. Louis MO 63119) Scharp David W. (1469 Willow Brook Cove St. Louis MO 63146) Ricordi Camillo (Corso Porta Nuova 10 20121 Milano ITX), Method to isolate clusters of cell subtypes from organs.
Hedrick, Marc H.; Fraser, John K.; Riley, Susan Lynn; Schreiber, Ronda Elizabeth, Methods of using regenerative cells in the treatment of musculoskeletal disorders.
Hu Can B. (Irvine CA) Ma Minh T. (Santa Ana CA) Nguyen Than (Huntington Beach CA) Rhee Richard (Diamond Bar CA) Myers Keith (El Toro CA), Microvessel cell isolation apparatus.
Tayot Jean-Louis (La Tour de Salvagny FRX) Tardy Michel (Lyons FRX), New preparation of placenta collagen, their extraction method and their applications.
Helmut Burtscher DE; Dorothee Ambrosius DE; Friederike Hesse DE, Recombinant collagenase type I from clostridium histolyticum and its use for isolating cells and groups of cells.
MacPhee Martin James ; Drohan William Nash ; Lasa ; Jr. Carlos I.,PHX ; Liau Gene ; Haudenschild Christian, Supplemented and unsupplemented tissue sealants, methods of their production and use.
Haller, Markus; Ferek-Petric, Bozidar; Donders, Adrianus P., System and method of communicating between an implantable medical device and a remote computer system or health care provider.
Mathias, Jean Marie; Blom, Agneta; Mespreuve, Luc; Vandendaul, Daniel; Payrat, Jean-Marc, Systems and methods for collecting plasma that is free or virtually free of cellular blood species.
Hedrick, Marc H.; Fraser, John K.; Schulzki, Michael J.; Byrnes, Bobby; Carlson, Grace; Schreiber, Ronda; Wulur, Isabella, Systems and methods for isolating and using clinically safe adipose derived regenerative cells.
Hedrick, Marc H.; Fraser, John K.; Schulzki, Michael J.; Byrnes, Bobby; Carlson, Grace; Shanahan, Robert K., Systems and methods for separating and concentrating adipose derived stem cells from tissue.
Gerson Stanton L. (Pepper Pike OH) Caplan Arnold I. (Cleveland Heights OH) Haynesworth Stephen E. (Cleveland Heights OH), Transduced mesenchymal stem cells.
Yuan-Di C. Halvorsen ; William O. Wilkison ; Jeffrey Martin Gimble, Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair.
Clarke Rolf W. (Balboa Island CA) Balding David P. (Mission Viejo CA) Gordon Lucas S. (Lagune Beach CA), Venous reservoir bag with integral high-efficiency bubble removal system.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.