A cardiac valve prosthesis for implantation at a native valve having leaflets includes a distal fixation member configured to be implanted downstream of a native valve and includes engagement arms configured to apply, to a native valve's downstream side, a first force directed upstream, when the dis
A cardiac valve prosthesis for implantation at a native valve having leaflets includes a distal fixation member configured to be implanted downstream of a native valve and includes engagement arms configured to apply, to a native valve's downstream side, a first force directed upstream, when the distal fixation member is implanted. The number of engagement arms matches the number of native valve leaflets. The prosthesis also includes a proximal fixation member configured to be implanted at least partially upstream of the native valve such that the proximal fixation member applies, to a native valve's upstream side, a second force directed downstream when the proximal fixation member is implanted. The application of the first and second forces is configured to couple the prosthesis to the native valve. The engagement arms and the proximal fixation member are configured to capture the leaflets of the native valve therebetween.
대표청구항▼
1. A cardiac valve prosthesis for implantation at a native valve having leaflets, comprising: a distal fixation member configured to be implanted downstream of a native valve and comprising engagement arms configured to apply, to a downstream side of the native valve, a first force directed upstream
1. A cardiac valve prosthesis for implantation at a native valve having leaflets, comprising: a distal fixation member configured to be implanted downstream of a native valve and comprising engagement arms configured to apply, to a downstream side of the native valve, a first force directed upstream, when the distal fixation member is implanted; wherein the number of engagement arms matches the number of leaflets of the native valve; anda proximal fixation member configured to be implanted at least partially upstream of the native valve such that the proximal fixation member applies, to an upstream side of the native valve, a second force directed downstream when the proximal fixation member is implanted;wherein application of the first and second forces is configured to couple the cardiac valve prosthesis to the native valve; andwherein the engagement arms and the proximal fixation member are configured to capture the leaflets of the native valve therebetween. 2. The cardiac valve prosthesis of claim 1, wherein the distal fixation member and the proximal fixation member are fabricated as one integrated structure. 3. The cardiac valve prosthesis of claim 1, wherein the proximal fixation member comprises a bulging skirt that is configured to apply the second force. 4. The cardiac valve prosthesis of claim 1, wherein the engagement arms are configured to limit an extent of opening of the leaflets of the native valve when the distal fixation member is implanted. 5. The cardiac valve prosthesis of claim 1, wherein the proximal and distal fixation members are configured to be collapsible and expandable. 6. The cardiac valve prosthesis of claim 5, wherein the proximal and distal fixation members are configured to be collapsible such that the proximal and distal fixation members can be advanced to the native valve using a transaortic approach, a transapical approach, or a transseptal approach. 7. The cardiac valve prosthesis of claim 1, wherein the engagement arms are configured to contact tissue adjacent and surrounding an annulus of the native valve when the distal fixation member is implanted. 8. The cardiac valve prosthesis of claim 7, wherein the tissue adjacent and surrounding the annulus of the native valve is a sinus of the native valve. 9. The cardiac valve prosthesis of claim 1, wherein application of the first and second forces couples the prosthesis to the native valve by sandwiching the native valve from a downstream side and the upstream side thereof 10. The cardiac valve prosthesis of claim 1, wherein the proximal and distal fixation members are configured such that any radial force applied by the proximal and distal fixation members outwardly against an annulus of the native valve is insufficient by itself to chronically maintain the cardiac valve prosthesis in position with respect to the annulus of the native valve under conditions of normal cardiac motion. 11. The cardiac valve prosthesis of claim 1, wherein the proximal and distal fixation members are configured to embrace, without squeezing, leaflets of the native valve. 12. The cardiac valve prosthesis of claim 1, wherein the native valve is selected from the group consisting of a mitral valve, an aortic valve, a pulmonary valve, and a tricuspid valve. 13. The cardiac valve prosthesis of claim 1, wherein the engagement arms and the proximal fixation member are configured to capture leaflets of the native valve therebetween without folding over leaflets of the native valve. 14. The cardiac valve prosthesis of claim 1, wherein the engagement arms each have a V-shape. 15. The cardiac valve prosthesis of claim 1, wherein the proximal fixation member defines a bulging skirt. 16. The cardiac valve prosthesis of claim 1, wherein the proximal fixation member is configured to reduce leakage around the cardiac valve prosthesis. 17. The cardiac valve prosthesis of claim 1, wherein the number of engagement arms is two and the number of leaflets of the native valve is two. 18. The cardiac valve prosthesis of claim 1, wherein the number of engagement arms is three and the number of leaflets of the native valve is three. 19. The cardiac valve prosthesis of claim 1, wherein the proximal fixation member and the distal fixation member are fabricated as separate components that are joined together in situ. 20. The cardiac valve prosthesis of claim 1, wherein the proximal fixation member and the distal fixation member are fabricated as one integrated structure.
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