Compositions and methods for stimulating hair growth
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/5575
A61K-008/34
A61K-008/39
A61K-008/37
A61K-008/36
A61Q-007/00
A61K-047/22
A61K-008/04
A61K-008/42
A61K-031/16
A61K-047/08
A61K-047/10
출원번호
US-0163954
(2014-01-24)
등록번호
US-9138480
(2015-09-22)
발명자
/ 주소
Trogden, John T.
Salameh, Adnan K.
Pujara, Chetan P.
출원인 / 주소
Allergan, Inc.
대리인 / 주소
Siddiqi, Lorenz
인용정보
피인용 횟수 :
2인용 특허 :
148
초록▼
Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent the presence or absence of a double bond which can be in the c
Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent the presence or absence of a double bond which can be in the cis or trans configuration and A, B, Z, X, R1 and R2 are as defined in the specification and a penetration enhancer. Such compositions are used in stimulating hair growth of human or non-human animals.
대표청구항▼
1. A composition for growing hair by topical application comprising: at least one penetration enhancer; and0.01% to 5% w/w bimatoprost;wherein said composition is formulated for topical administration to the skin;wherein the penetration enhancer comprises a combination of a first penetration enhance
1. A composition for growing hair by topical application comprising: at least one penetration enhancer; and0.01% to 5% w/w bimatoprost;wherein said composition is formulated for topical administration to the skin;wherein the penetration enhancer comprises a combination of a first penetration enhancer group comprising ethanol, propylene glycol, and diethylene glycol monoethyl ether; and a second penetration enhancer group comprising an effective amount of at least two compounds selected from the group consisting of glycerol monooleate, oleic acid, and benzyl alcohol. 2. The composition of claim 1 wherein the composition comprises 1% w/w bimatoprost. 3. The composition according to claim 1 wherein the composition is in the form of one selected from the group consisting of solutions, gels, ointments, foams, films, liniments, creams, shampoos, lotions, pastes, jellies, sprays and aerosols. 4. The composition of claim 3 wherein the composition is packaged in a kit with an applicator for application to the skin. 5. A method for stimulating hair growth comprising topically administering a composition comprising: at least one penetration enhancer; andbimatoprost;wherein said composition is formulated for topical administration to the skin;wherein the penetration enhancer comprises a combination of a first penetration enhancer group comprising ethanol, propylene glycol, and diethylene glycol monoethyl ether; and a second penetration enhancer group comprising an effective amount of at least two compounds selected from the group consisting of glycerol monooleate, oleic acid, and benzyl alcohol. 6. The method according to claim 5 comprising bimatoprost at a concentration of about 0.03% w/w to about 5% w/w. 7. The method according to claim 5, wherein the composition is applied at least once daily to the scalp. 8. The method according to claim 5, wherein the composition is applied at least once daily to the scalp for treatment of one of the following conditions selected from the group consisting of alopecia areata, telogen effluvium, anagen effluvium, cicatricial alopecia, scarring alopecia; hair shaft abnormalities, trichorrexis nodosa, loose anagen syndrome, trichotillomania, traction alopecia; infectious hair disorders, tiniea capitis, sebohorreic dermatitis, follicullitus of the scalp, and androgenetic alopecia. 9. The method according to claim 5 wherein the composition is applied at least once a day to both the scalp and the eyebrows for patients experiencing hair loss due to chemotherapy, hormonal imbalance, fungal infection of the scalp, anti-coagulants, medicine for gout, depression, high blood pressure and heart disease. 10. The composition of claim 1, wherein the second penetration enhancer group comprises glycerol monooleate, oleic acid, and benzyl alcohol. 11. The method of claim 5 comprising bimatoprost at a concentration of 0.3% w/w. 12. The method of claim 5 comprising bimatoprost at a concentration of 1% w/w. 13. The method of claim 5, wherein the second penetration enhancer group comprises glycerol monooleate, oleic acid, and benzyl alcohol.
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