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Amino lipids and methods for the delivery of nucleic acids 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07D-317/28
  • A61K-009/127
  • C07D-319/06
출원번호 US-0123307 (2009-10-09)
등록번호 US-9139554 (2015-09-22)
국제출원번호 PCT/US2009/060251 (2009-10-09)
§371/§102 date 20110701 (20110701)
국제공개번호 WO2010/042877 (2010-04-15)
발명자 / 주소
  • Hope, Michael J.
  • Semple, Sean C.
  • Chen, Jianxin
  • Madden, Thomas D.
  • Cullis, Pieter R.
  • Ciufolini, Marco A.
  • Mui, Barbara Low Shoud
출원인 / 주소
  • Tekmira Pharmaceuticals Corporation
대리인 / 주소
    Viksnins Harris & Padys PLLP
인용정보 피인용 횟수 : 6  인용 특허 : 191

초록 ▼

The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid t

대표청구항

1. An amino lipid having the structure:

이 특허에 인용된 특허 (191)

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  • Haralambidis Jim (Victoria AUX), Nucleoside derivatives.
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  • Meyer ; Jr. Rich B. (Woodinville WA) Adams A. David (Snohomish WA) Petrie Charles R. (Woodinville WA), Oligo (aa 상세보기
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  • Chaturvedula Prasad Venkata Chala (Exton PA), Oligonucleotide dimers with amide linkages replacing phosphodiester linkages.
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  • Busch Harris (Houston TX) Bennett Clarence Frank (Carlsbad CA) Perlaky Laszlo (Houston TX) Saijo Yasuo (Sendai JPX) Busch Rose K. (Houston TX), Oligonucleotide modulation of cell growth.
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  • Maag Hans (Menlo Park CA) Rose Samuel J. (Mountain View CA) Schmidt Beat (Baltschieder CHX), Oligonucleotides containing 4′-substituted nucleotides.
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  • Froehler Brian (Belmont CA), Oligonucleotides with inverted polarity.
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  • Lebleu Bernard (Montpellier FRX) Bayard Bernard (Castelnau Le Lez FRX), Oligonucleotides with modified phosphate and modified carbohydrate moieties at the respective chain termini.
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  • Barascut Jean-Louis (Combaillaux FRX) Imbach Jean-Louis (Montpellier FRX), Oligothionucleotides.
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  • Nielsen Peter E. (Hjortevanget 509 DK 2980 Kokkedal DKX) Buchardt Ole (Sondergardsvej 73 DK 3500 Vaerlose DKX) Egholm Michael (Johnstrup Alle 3 DK 1923 Frederiksberg DKX) Berg Rolf H. (Strandvaenget , Peptide nucleic acids.
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  • Dwyer Brian Patrick ; Lehedev Alexandre V. ; Brown Bob Dale ; Schwartz David Aaron, Phosphonic acid-based cationic lipids.
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  • Choi Lewis S. L.,CAX ; Madden Thomas D.,CAX ; Webb Murray S.,CAX, Polyethylene glycol modified ceramide lipids and liposome uses thereof.
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  • Heyes, James; MacLachlan, Ian; Ambegia, Ellen Grace, Polyethyleneglycol-modified lipid compounds and uses thereof.
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  • Acevedo Oscar L. (San Diego CA) Hebert Normand (San Marcos CA), Pyrrolidine-containing monomers and oligomers.
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  • Gebeyehu Gulilat ; Jessee Joel A., Reagents for intracellular delivery of macromolecules.
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  • Bowles, Henry M.; Langley, Theodore D., Relocatable mental function testing gateway.
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  • Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR), Sequence-specific binding polymers for duplex nucleic acids.
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  • Agrawal, Sudhir; Tang, Jinyan, Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling.
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  • Cook Phillip Dan (Carlsbad CA) Kawasaki Andrew Mamoro (Oceanside CA), Sugar modified oligonucleotides that detect and modulate gene expression.
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  • Sproat Brian (Heidelberg DEX) Lamond Angus (Wiesenbach DEX) Paolella Giovanni (Gaiberg DEX), Synthetic catalytic oligonucleotide structures.
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  • Debs Robert James (Mill Valley CA) Zhu Ning (El Cerrito CA), Transfection of lung via aerosolized transgene delivery.
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  • Chu, Yongliang; Masoud, Malek; Gebeyehu, Gulilat, Transfection reagents.
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  • Chu, Yongliang; Masoud, Malek; Gebeyehu, Gulilat, Transfection reagents.
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  • Chu, Yongliang; Masoud, Malek; Gebeyehu, Gulilat, Transfection reagents.
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  • Chu,Yongliang; Masoud,Malek; Gebeyehu,Gulilat, Transfection reagents.
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  • Chu,Yongliang; Masoud,Malek; Gebeyehu,Gulilat, Transfection reagents.
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  • Summerton, James E.; Weller, Dwight D., Uncharged morpholino-based polymers having achiral intersubunit linkages.
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  • Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR), Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages.
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  • Heather L. Davis CA; Joachim Schorr DE; Arthur M. Krieg, Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant.
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  • Highsmith, Roderick, Waste water disposal system.
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