Rapidly dissolving film for delivery of an active agent
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/70
A61K-009/46
A61K-009/00
출원번호
US-0171612
(2014-02-03)
등록번호
US-9144552
(2015-09-29)
발명자
/ 주소
Singh, Parminder
Mudumba, Sri
Bayramov, Danir F.
Kulichikhin, Valery G.
Feldstein, Mikhail M.
Cleary, Gary W.
출원인 / 주소
A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
대리인 / 주소
Mohr, Judy M.
인용정보
피인용 횟수 :
2인용 특허 :
254
초록
A rapidly dissolving film is provided for delivery of an active agent to a moist body surface, e.g., mucosal tissue. The film comprises a film-forming binder, a rapidly dissolving polymeric material, and an active agent.
대표청구항▼
1. A film for administration of an active agent to a body surface, the film comprising: a blend comprised of a hydrophilic polymer and a plasticizer miscible with the hydrophilic polymer, the hydrophilic polymer and the plasticizer blended to form non-covalent bonds between the hydrophilic polymer a
1. A film for administration of an active agent to a body surface, the film comprising: a blend comprised of a hydrophilic polymer and a plasticizer miscible with the hydrophilic polymer, the hydrophilic polymer and the plasticizer blended to form non-covalent bonds between the hydrophilic polymer and the plasticizer, wherein the hydrophilic polymer has an average molecular weight of approximately 100,000 to 2,000,000 Daltons and wherein the plasticizer is present in the film at a weight percent (wt%) of 10 to 40wherein the wt% of the plasticizer is based on the film composition exclusive of the active agent,a rapidly dissolving polymeric material; andan effective amount of an active agent,wherein the blend and the rapidly dissolving material are effective to facilitate dissolution of the film within 10 minutes following application of the film to a moist body surface. 2. The film of claim 1, wherein the hydrophilic polymer comprises repeating units derived from monomers selected from N-vinyl lactam monomers, carboxy vinyl monomers, vinyl ester monomers, esters of a carboxy vinyl monomer, vinyl amide monomers, hydroxy vinyl monomers, and combinations thereof. 3. The film of claim 1, wherein the hydrophilic polymer is selected from poly(N-vinyl lactams), poly(N-vinyl amides), poly(N-vinyl acrylamides), poly(N-alkylacrylamides), poly(N-vinyl acetamides), substituted and unsubstituted acrylic and methacrylic acid polymers, polyvinyl alcohol, polyvinylamine, and copolymers and blends thereof. 4. The film of claim 1, wherein the hydrophilic polymer is selected from poly(N-vinyl lactams), poly(N-vinyl amides), poly(N-alkylacrylamides), and copolymers and blends thereof. 5. The film of claim 1, wherein the hydrophilic polymer is a poly(N-vinyl lactam). 6. The film of claim 1, wherein the hydrophilic polymer is a poly(N-vinyl lactam) homopolymer. 7. The film of claim 6, wherein the poly(N-vinyl lactam) is selected from polyvinyl pyrrolidone, polyvinyl caprolactam, and blends thereof. 8. The film of claim 7, wherein the poly(N-vinyl lactam) is polyvinyl pyrrolidone. 9. The film of claim 7, wherein the poly(N-vinyl lactam) is polyvinyl caprolactam. 10. The film of claim 1, wherein the hydrophilic polymer has a number average molecular weight in the range of approximately 500,000 to 1,500,000. 11. The film of claim 1, wherein the plasticizer is selected from the group consisting of dialkyl phthalates, dicycloalkyl phthalates, diaryl phthalates, mixed alkyl-aryl phthalates, alkyl phosphates, aryl phosphates, alkyl citrates, citrate esters, alkyl adipates, dialkyl tartrates, dialkyl sebacates, dialkyl succinates, alkyl glycolates, alkyl glycerolates, glycol esters, glycerol esters, and mixtures thereof. 12. The film of claim 1, wherein the plasticizer is selected from dimethyl phthalate, diethyl phthalate, dipropyl phthalate, di(2-ethylhexyl)phthalate, di-isopropyl phthalate, diamyl phthalate, dicapryl phthalate, tributyl phosphate, trioctyl phosphate, tricresyl phosphate, triphenyl phosphate, trimethyl citrate, triethyl citrate, tributyl citrate, acetyl triethyl citrate, trihexyl citrate, dioctyl adipate, diethyl adipate, di(2 -methylethyl)adipate, dihexyladipate, diethyl tartrate, dibutyl tartrate, diethyl sebacate, dipropyl sebacate, dinonyl sebacate, diethyl succinate, dibutyl succinate, glycerol diacetate, glycerol triacetate, glycerol mono lactate diacetate, methyl phthalyl ethyl glycolate, butyl phthalyl butyl glycolate, ethylene glycol diacetate, ethylene glycol dibutyrate, triethylene glycol diacetate, triethylene glycol dibutyrate, triethylene glycol dipropionate, and mixtures thereof. 13. The film of claim 1, wherein the plasticizer is selected from tributyl phosphate, trioctyl phosphate, triphenyl phosphate, trimethyl citrate, triethyl citrate, and tributyl citrate. 14. The film of claim 1, comprising 40 to 60 wt% of the hydrophilic polymer, wherein the wt% of the hydrophilic polymer is based on the film composition exclusive of the active agent. 15. The film of claim 1, wherein the plasticizer is a bifunctional, linear oligomer having a functional group at each terminus, each of said terminal functional groups capable of non-covalently binding to the hydrophilic polymer. 16. The film of claim 15, wherein the bifunctional, linear oligomer has a molecular weight in the range of approximately 45 Daltons to approximately 800 Daltons. 17. The film of claim 15, wherein the bifunctional, linear oligomer is polyethylene glycol. 18. The film of claim 17, wherein the polyethylene glycol has a molecular weight of 400. 19. The film of claim 15, wherein the bifunctional, linear oligomer has a molecular weight in the range of approximately 45 Daltons to approximately 600 Daltons. 20. The film of claim 15, wherein the terminal functional groups are selected from hydroxyl, carboxy, and amino groups. 21. The film of claim 15, wherein the terminal functional groups are selected from hydroxyl and carboxy groups. 22. The film of claim 15, wherein the terminal functional groups are hydroxyl groups. 23. The film of claim 22, wherein the hydrophilic polymer and the plasticizer have a weight ratio of about 1:10 to 10:1. 24. The film of claim 22, wherein the hydrophilic polymer and the plasticizer have a weight ratio of about 1.5:1 to about 3:1. 25. The film of claim 22, wherein the hydrophilic polymer and the plasticizer have a weight ratio of about 2:1. 26. The film of claim 1, wherein the rapidly dissolving polymeric material is selected from the group consisting of oligosaccharides, polysaccharides, crosslinked polyvinylpyrrolidone, alginic acid, agar, and bentonite. 27. The film of claim 1, wherein the rapidly dissolving polymeric material is selected from oligosaccharides and polysaccharides. 28. The film of claim 1, wherein the rapidly dissolving polymeric material is a cellulose derivative having a molecular weight of between about 1,000 Daltons to 300,000 Daltons. 29. The film of claim 1, wherein the rapidly dissolving polymeric material is maltodextrin. 30. The film of claim 1, wherein the active agent is a pharmacologically active agent and the effective amount is a therapeutically effective amount. 31. The film of claim 30, wherein the active agent is a locally acting agent. 32. The film of claim 30, wherein the active agent is a systemically acting agent. 33. The film of claim 1, wherein the active agent is contained in discrete particles dispersed throughout the film. 34. The film of claim 1, which dissolves within about 5 to 30 seconds following application of the film to a moist body surface. 35. The film of claim 1, which dissolves in less than about 30 seconds following application of the film to a moist body surface. 36. The film of claim 1, having a thickness of at least one 1 mm. 37. The film of claim 1, having a thickness in the range of about 100 mm to 200 mm. 38. A method for administering an active agent to a patient, comprising placing the film of claim 1 on a moist body surface of the patient and allowing the film to dissolve. 39. The method of claim 38, wherein the moist body surface of the patient is mucosal tissue. 40. The method of claim 38, wherein the moist body surface is selected from skin that is externally moistened. 41. A film for administration of an active agent to a body surface, the film comprising: (a) a blend consisting of (i) a hydrophilic polymer having an average molecular weight of approximately 100,000 to 2,000,000 Daltons, and (ii) about 10 to 40 wt% of a plasticizer having a molecular weight of between 45 to 800 Daltons, and(b) rapidly dissolving polymeric material, the hydrophilic polymer and the plasticizer blended to form non-covalent bonds between the hydrophilic polymer and the plasticizer, wherein the wt% of the plasticizer and of the rapidly dissolving polymeric material is each based on the film composition exclusive of the active agent; andan effective amount of an active agent,wherein the blend and the rapidly dissolving material are effective to facilitate dissolution of the film within 10 minutes following application of the film to a moist body surface. 42. The film of claim 41, wherein the hydrophilic polymer is selected from poly(N-vinyl lactams), poly(N-vinyl amides), poly(N-alkylacrylamides), and copolymers and blends thereof. 43. The film of claim 41, wherein the hydrophilic polymer is a poly(N-vinyl lactam). 44. The film of claim 43, wherein the poly(N-vinyl lactam) is polyvinyl pyrrolidone. 45. The film of claim 41, wherein the hydrophilic polymer has a number average molecular weight in the range of approximately 500,000 to 1,500,000 Daltons. 46. The film of claim 41, wherein the rapidly dissolving polymeric material is selected from the group consisting of oligosaccharides, polysaccharides, crosslinked polyvinylpyrrolidone, alginic acid, agar, and bentonite. 47. The film of claim 41, wherein the active agent is for treatment of a condition involving teeth or surrounding tissue.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (254)
Parker, Hsing-Yeh; Merritt, Richard Foster; Fu, Zhenwen; Ibbitson, Scott Alan; Gore, Robert Howard; Wolfersberger, Martha Alice Harbaugh, Acrylic polymer compositions with crystalline side chains and processes for their preparation.
Schiraldi Michael T. (East Brunswick NJ) Perl Martin M. (Brooklyn NY) Rubin Howard (Rockaway NJ), Bioadhesive extruded film for intra-oral drug delivery and process.
Anderson John McCune (16 Torgrange Holywood ; County Down ; BT18 ONG ; Northern Ireland GBX) McAdams Eric Thomas (Ormsdale ; 52 Cable Road Whitehead ; County Antrim ; Northern Ireland BT38 9 PZ GBX) , Biomedical electrode device.
Arraudeau Jean-Pierre (Paris FRX) Patraud Jeanne (Paris FRX) Le Gall Louis (Bures-sur-Yvette FRX), Composition based on cationic polymers, anionic polymers and waxes for use in cosmetics.
Kulichikhin,Valery G.; Parandoosh,Shoreh; Feldstein,Mikhail M.; Antonov,Sergey; Cleary,Gary W., Composition for cushions, wound dressings and other skin-contacting products.
Kulichikhin,Valery G.; Parandoosh,Shoreh; Feldstein,Mikhail M.; Antonov,Sergey; Cleary,Gary W., Composition for cushions, wounds dressings and other skin-contacting products.
Takoh Noboru,JPX ; Kondo Masahiro,JPX ; Inoue Hiroshi,JPX, Composition used for hydrophilization and method for hydrophilization using said composition.
Kanios David P. ; Gentile Joseph A. ; Mantelle Juan A. ; Sablotsky Steven, Compositions and methods for topical administration of pharmaceutically active agents.
Bloom Roberta C. (Huntington CT) Deckner George E. (Cincinnati OH), Compositions for topical delivery of drugs comprising a mixture of high and low HLB surfactants and alkoxylated ether.
Magnus, Philip D.; Payne, Andrew H., Conversion of α,β-unsaturated ketones and α,β-unsaturated esters into α-hydroxy ketones and α-hydroxy esters using Mn(III) catalyst, phenylsilane and dioxygen.
Lee Eun Soo (Redwood City CA) Theeuwes Felix (Los Altos Hills CA) Wong S. L. Patrick (Hayward CA) Yum Su Il (Los Altos CA) Zaffaroni Alejandro (Atherton CA), Delayed onset transdermal delivery device.
Sagel Paul A. ; Dirksing Robert S. ; Rohman Frederick J., Delivery system for a tooth whitener using a strip of material having low flexural stiffness.
Sagel Paul Albert ; Dirksing Robert Stanley ; Rohman Frederick James, Delivery system for a tooth whitener using a strip of material having low flexural stiffness.
Dirksing Robert S. ; Sagel Paul A. ; Tweddell ; III Richard, Delivery system for an oral care substance using a permanently deformable strip of material.
Sagel Paul A. ; Dirksing Robert S. ; Rohman Frederick J., Delivery system for an oral care substance using a strip of material having low flexural stiffness.
Sagel Paul Albert ; Dirksing Robert Stanley ; Rohman Frederick James ; Majeti Satyanarayana ; Reno Elizabeth Ann, Delivery system for an oral care substance using a strip of material having low flexural stiffness.
Curtis John (Bloomsbury NJ) Nahoo Salim (Piscataway NJ) Prencipe Michael (E. Windsor NJ), Dental material and method for applying preventative and therapeutic agents.
Chang Yunik (Toms River NJ) Patel Dinesh C. (Murray UT) Ebert Charles D. (Salt Lake City UT), Device for administering an active agent to the skin or mucosa.
Chang Yunik (Toms River NJ) Patel Dinesh C. (Murray UT) Ebert Charles D. (Salt Lake City UT), Device for administering an active agent to the skin or mucosa.
Chheang, Theary; Hine, Andrew M.; Muggli, Mark W.; Noe, Susan C.; Sanft, Patricia M.; Schultz, William J.; Taylor, Robert D.; Tead, Stanley F., Devices, compositions, and methods incorporating adhesives whose performance is enhanced by organophilic clay constituents.
Gyory J. Richard (Los Altos CA) Haak Ronald P. (Cupertino CA) Theeuwes Felix (Los Altos CA) Lew Patrick J. (Mountain View CA), Electrotransport adhesive.
Tseng Susan Y. (Staten Island NY) Wolf Philip F. (Bridgewater NJ) Burlant William J. (Wayne NJ), Films and extrusions of cured crosslinked vinyl lactam polymer and method of preparation.
Roreger Michael (Neuwied DEX) Herrmann Fritz (Neuwied DEX) Hoffmann Hans-Rainer (Neuwied DEX) List Harald (Neuwied DEX), Flexible, hydrophilic gel film, the process for its production and the use of it.
Singh, Parminder; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bairamov, Danir R., Hydrogel compositions demonstrating phase separation on contact with aqueous media.
Singh, Parminder; Faasse, Adrian; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bairamov, Danir R., Hydrogel compositions with an erodible backing member.
Holmblad Carolann M. (Cambridge MN) Bergstrom Joan M. (Minneapolis MN) Bartlett Terese A. (Circle Pines MN), Hydrophilic pressure sensitive adhesive for topical administration of hydrophobic drugs.
Jevne Allan H. (Anoka MN) Vegoe Brett R. (Brooklyn Park MN) Holmblad Carolann M. (Cambridge MN) Cahalan Patrick T. (Champlin MN), Hydrophilic pressure sensitive biomedical adhesive composition.
Nielsen Kent E.,CAX ; Li Kai,CAX ; Kantner Steven S. ; Koski Nancy L. ; Everaerts Albert I., Ionically conductive adhesives prepared from zwitterionic materials and medical devices using such adhesives.
Gyory J. Richard (Los Altos CA) Haak Ronald P. (Cupertino CA) Theeuwes Felix (Los Altos CA) Lew Patrick J. (Mountain View CA), Iontophoretic device incorporating an electrotransport adhesive.
Samour Carlos ; Krauser Scott F., Lipophilic and amphiphilic or hydrophilic film-forming polymer compositions, and use thereof in topical agent delivery.
Broberg Berndt F. J. (Sdertlje SEX) Evers Hans C. A. (Sdertlje SEX), Local anesthetic mixture for topical application and method for obtaining local anesthesia.
Broberg, Berndt F. J.; Evers, Hans C. A., Local anesthetic mixture for topical application, process for its preparation, as well as method for obtaining local anesthesia.
Itoh Steven K. (Cottage Grove MN) Dietz Timothy M. (St. Paul MN) Uy Rosa (St. Paul MN), Low impedance pressure sensitive adhesive composition and biomedical electrodes using same.
Yeo, Woon-Sung; Yun, Yeo-Han, Method for forming an information recording medium having information on spare area, and method and apparatus for recording/reproducing data to/from the medium.
Barton James Bradbury ; Shari Joy Soper ; Joseph Robert Kaczvinsky, Jr. ; Dorothy Limerick Bailey ; Celeste Dawn Gale, Method for regulating hair growth.
Gleich Gerald J. (Rochester MN) Ohnishi Tsukasa (Tokyo JPX) Hunt Loren W. (Rochester MN), Method for the treatment of eosinophil-associated diseases by administration of topical anesthetics.
Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Method of Selectively applying needle array configurations.
Moro, Daniel G.; Callahan, Howard; Nowotnik, David, Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds.
Tucker Mark J. (Round Steps ; High Street Stow-on-the-Wold ; Gloucester GL54 1DL GBX) Tucker Mark R. (P.O. Box 23530 Bahrain BHX), Occlusive body for administering a physiologically active substance.
Patel Dinesh C. (Murray UT) Chang Yunik (Lakewood NJ), Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols.
Lerner E. Itzhak,ILX ; Rosenberger Vered,ILX ; Flashner Moshe,ILX, Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity.
Dietz Timothy M. (St. Paul MN) Lu Ying-Yuh (Woodbury MN) Uy Rosa (St. Paul MN) Young Chung I. (Roseville MN), Polymerized microemulsion pressure sensitive adhesive compositions and methods of preparing and using same.
Feldstein, Mikhail M.; Plate, Nicolai A.; Chalykh, Anatoly E.; Cleary, Gary W., Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties.
Therriault Donald J. (Lowell MA) Temin Samuel C. (Needham MA) Shah Kishore R. (Bridgewater NJ), Pressure-sensitive hydrophilic laminate structures for use in wound dressing, transdermal and topical drug delivery.
Duan Daniel C. (St. Paul MN) Asmus Robert A. (Township of Hudson ; County of St. Croix WI) Dietz Timothy M. (St. Paul MN) Uy Rosa (St. Paul MN) Benson ; Jr. Olester (Woodbury MN), Pressure-sensitive poly(n-vinyl lactam) adhesive composition and method for producing and using same.
Plate Nicolai A.,RUX ; Valuev Lev I.,RUX ; Uzhinova Lubov D.,RUX ; Sinani Vladimir A.,RUX, Process for preparing biologically compatible polymers and their use in medical devices.
Pfister William R. (Bay City MI) Wilson Jeniffer M. (Saginaw MI), Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices.
Lee Eun Soo (Redwood City CA) Nedberge Diane E. (Los Altos CA) Yum Su Il (Los Altos CA), Skin permeation enhancer compositions using glycerol monolinoleate.
Chiang Chia-Ming (Foster City CA) Cleary Gary W. (San Mateo CA), Skin permeation enhancer compositions, and methods and transdermal systems associated therewith.
Miranda Jesus (Miami FL) Sablotsky Steven (Miami FL), Solubility parameter based drug delivery system and method for altering drug saturation concentration.
Wagner Julie Ann ; Zukowski Joseph Michael ; Robinson Larry Richard ; Deckner George Endel ; Rinaldi Marie Antoinette ; Szymanski Victoria Claire, Stable topical compositions.
Jones, Todd K.; Goldman, Mark E.; Pooley, Charlotte L. F.; Winn, David T.; Edwards, James P.; West, Sarah J.; Tegley, Christopher M.; Zhi, Lin; Hamann, Lawrence G.; Farmer, Luc J.; Davis, Robert L., Steroid receptor modulator compounds and methods.
Enscore David J. (Sunnyvale CA) Campbell Patricia S. (Palo Alto CA) Osborne James L. (Mountain View CA) Smart Melinda K. (Sunnyvale CA) Yum Su I. (Los Altos CA), Subsaturated transdermal therapeutic system having improved release characteristics.
Enscore David J. (Sunnyvale CA) Campbell Patricia S. (Palo Alto CA) Osborne James L. (Mountain View CA) Smart Melinda K. (Sunnyvale CA) Yum Su I. (Los Altos CA), Subsaturated transdermal therapeutic system having improved release characteristics.
Turner Josephine S. (Kettleby CAX) Murray D. Gary (Willowdale CAX) Zuccolin John D. (Stouffville CAX) Li Ruey S. (Thornhill CAX), Substance transfer system for topical application.
Gale Robert M. (Los Altos CA) Nedberge Diane E. (Los Altos CA) Atkinson Linda E. (Portola Valley CA), Transdermal contraceptive formulations, methods and devices.
Min Dong Son,KRX ; Um Kee An,KRX ; Kim Yong Soo,KRX ; Park Pyeong Uk,KRX ; Kim Key Hyup,KRX ; Yang Ho Seung,KRX ; Jeong Hey Soon,KRX ; Park Mi Young,KRX, Transdermal delivery matrix for piroxicam.
Ebert Charles D. (Salt Lake City UT) Heiber Werner (Salt Lake City UT) Good William R. (Salt Lake City UT) Venkateshwaran Srinivasan (Salt Lake City UT), Transdermal delivery system with adhesive overlay and peel seal disc.
Chiang Chia-Ming (Foster City CA) Colley Kenneth J. (Washington DC) Cleary Gary W. (San Mateo CA), Transdermal drug delivery device using an unfilled microporous membrane to achieve delayed onset.
Ma Xinghang ; Audett Jay ; Soni Pravin L. ; Singh Noel ; Bailey Susan E., Transdermal drug delivery sytem for the administration of tamsulosin, and related compositions and methods of use.
Chien Yie W. (North Brunswick NJ) Chien Te-Yen (Piscataway NJ) Huang Yih-Chain (Piscataway NJ), Transdermal estrogen/progestin dosage unit, system and process.
Jona Janan ; Audett Jay ; Singh Noel, Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen.
Jona Janan ; Audett Jay ; Singh Noel, Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen.
Horstmann Michael (Neuwied DEX) Herrmann Fritz (Neuwied DEX), Transdermal therapeutic system exhibiting an increased active substance flow and process for the production thereof.
Kleinsorgen Reinhard v.,DEX ; Kleinsorgen Britta v.,DEX, Transdermal therapeutic system with small application-area thickness and great flexibility, and production process.
Jan A. Orlowski ; David V. Butler, Two-part composition for high efficacy teeth whitening comprising a mixture of peroxides and/or percarbonates of metals.
Dietz Timothy M. (St. Paul MN) Asmus Robert A. (Hudson WI) Uy Rosa (St. Paul MN), Two-phase composites of ionically-conductive pressure-sensitive adhesive, biomedical electrodes using the composites, an.
Login Robert B. (Oakland NJ) Merianos John J. (Middletown NJ) Biss Russell B. (Paramus NJ) Garelick Paul (South Plainfield NJ), Urea-hydrogen peroxide-polyvinylpyrrolidone.
Login Robert B. (Oakland NJ) Merianos John J. (Middletown NJ) Biss Russell B. (Wayne NJ) Garelick Paul (South Plainfield NJ), Urea-hydrogen peroxide-polyvinylpyrrolidone process.
Kantner Steven S. ; Kuester Wilhelm,DEX, Use of pendant free-radically polymerizable moieties with polar polymers to prepare hydrophilic pressure sensitive adhes.
Gaglio Thomas J. (4421 La Paloma Santa Barbara CA 93105) Santoriello Luigi (3463 State St. ; #359 Santa Barbara CA 93105), Viscous fluid dispensing apparatus.
Kim Son Nguyen,DEX ; Sanner Axel,DEX ; Hossel Peter,DEX ; Schehlmann Volker,DEX, Water-soluble or water-dispersible graft copolymers based on a polyvinyllactam, their preparation and use.
Biegajski James E. (Foster City CA) Venkatraman Subbu S. (Palo Alto CA) Scott Ann M. (Mountain View CA), Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavi.
Beier Helmut (Darmstadt DEX) Petereit Hans-Ulrich (Darmstadt DEX) Bergmann Gunter (Hanau DEX), Water-soluble pressure-sensitive skin adhesive, its use, and agents provided with it.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.