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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0297487 (2011-11-16) |
등록번호 | US-9147037 (2015-09-29) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 464 |
Methods and algorithms for automated allele assignments within an integrated software environment are provided. These methods and algorithms offer a multiplicity of functionalities including: data management; system configuration including user authorization, training set analysis and probe masking;
Methods and algorithms for automated allele assignments within an integrated software environment are provided. These methods and algorithms offer a multiplicity of functionalities including: data management; system configuration including user authorization, training set analysis and probe masking; pattern analysis including string matching and probe flipping; and interactive redaction of data. The methods and algorithms further include methods of setting thresholds, refining thresholds, and probe masking of signals produced by probes which do not contribute significantly to discriminating among alleles.
1. A method comprising: (i) providing a set of primers that generate targets from genomic regions which include a polymorphic locus of interest;(ii) providing an expanded probe set comprising a core subset of probes that hybridize only to particular targets with particular alleles and a second subse
1. A method comprising: (i) providing a set of primers that generate targets from genomic regions which include a polymorphic locus of interest;(ii) providing an expanded probe set comprising a core subset of probes that hybridize only to particular targets with particular alleles and a second subset of probes that hybridize to multiple targets;(iii) exposing the targets to the expanded probe set under reaction conditions such that hybridization of targets and probes generates a signal;(iv) masking the signal of hybridization of targets and members of the second subset of probes; and(v) performing initial allele group assignments based only on the signal of hybridization of targets and members of the core subset of probes(vi) performing, after step (v), allele group assignments based on the signal of hybridization of targets and the second subset of probes. 2. The method of claim 1, further comprising making final allele assignments where allele group assignments made based on the second probe set agree with allele group assignments made based on the first subset of probes.
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