Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-035/50
A61K-035/48
A61K-038/17
A61K-038/39
A61K-038/48
C07K-014/47
C07K-014/78
C07K-014/81
출원번호
US-0802359
(2013-03-13)
등록번호
US-9161955
(2015-10-20)
발명자
/ 주소
Tseng, Scheffer
He, Hua
Li, Wei
출원인 / 주소
TISSUETECH, INC.
대리인 / 주소
Wilson Sonsini Goodrich & Rosati
인용정보
피인용 횟수 :
4인용 특허 :
74
초록▼
Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtai
Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.
대표청구항▼
1. A method of inhibiting or reversing scar formation in an individual in need thereof, comprising administering a ground or pulverized amniotic membrane derived from a frozen or previously frozen placental material. 2. The method of claim 1, wherein the ground or pulverized amniotic membrane is in
1. A method of inhibiting or reversing scar formation in an individual in need thereof, comprising administering a ground or pulverized amniotic membrane derived from a frozen or previously frozen placental material. 2. The method of claim 1, wherein the ground or pulverized amniotic membrane is in the form of a homogenate. 3. The method of claim 1, wherein the ground or pulverized amniotic membrane is in the form of a dry powder, liquid or suspension. 4. The method of claim 1, wherein the placental material is placenta. 5. The method of claim 1, wherein the amniotic membrane is human amniotic membrane, bovine amniotic membrane, or porcine amniotic membrane. 6. A method of inhibiting or reversing scar formation in an individual in need thereof, comprising administering a composition comprising a ground or pulverized amniotic membrane derived from a frozen or previously frozen placental material. 7. The method of claim 6, wherein the placental material is placenta. 8. The method of claim 6, wherein the composition further comprises a pharmaceutically-acceptable excipient. 9. The method of claim 6, wherein the composition is a non-solid dosage form. 10. The method of claim 9, wherein the composition is a solution, suspension, paste, ointment, oil, emulsion, cream, lotion, gel, patch, stick, balm, or shampoo. 11. The method of claim 6, wherein the composition is an ophthalmic composition. 12. The method of claim 6, wherein the composition is a topical composition.
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