Neural stimulation devices and systems for treatment of chronic inflammation
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/00
A61N-001/36
A61N-001/372
A61N-001/375
A61N-001/378
A61N-001/05
출원번호
US-0508940
(2014-10-07)
등록번호
US-9162064
(2015-10-20)
발명자
/ 주소
Faltys, Michael A.
Simon, Jesse M.
Liu, Yiming
출원인 / 주소
SetPoint Medical Corporation
대리인 / 주소
Shay Glenn LLP
인용정보
피인용 횟수 :
10인용 특허 :
244
초록▼
A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The
A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (10 minutes per week) charge an implanted microstimulator. The external controller may be configured as a prescription pad that controls the dosing and activity of the microstimulator.
대표청구항▼
1. A leadless, implantable microstimulator device for treating chronic inflammation, the device comprising: a hermetically sealed capsule body;at least two electrically conductive capsule regions, wherein each region electrically connects to an electrode for applying stimulation to a vagus nerve;a r
1. A leadless, implantable microstimulator device for treating chronic inflammation, the device comprising: a hermetically sealed capsule body;at least two electrically conductive capsule regions, wherein each region electrically connects to an electrode for applying stimulation to a vagus nerve;a resonator within the sealed capsule body, the resonator comprising a coil and a capacitor configured to resonate at a predetermined frequency range;a thermistor positioned to monitor the temperature of the coil;a battery within the sealed capsule body; andan electronic assembly within the sealed capsule body;wherein the electronic assembly comprises power management circuitry configured to receive power from the resonator to charge the battery, a microcontroller configured to control stimulation of the vagus nerve from the conductive capsule regions, and an overtemperature control configured to detune the resonator to reduce energy absorption when the thermistor measures a temperature exceeding a predetermined threshold temperature. 2. The device of claim 1, wherein the overtemperature control is configured to shut the device down if the operating temperature exceeds 41° C. 3. The device of claim 1, wherein the electronic assembly further comprises one or more voltage limiters to limit the amount of power that can charge the battery from the resonator. 4. The device of claim 1, wherein the electronic assembly further comprises a shorting switch configured to detune the resonator. 5. The device of claim 1, wherein the electronic assembly further comprises an overvoltage sensor configured to detune the resonator to reduce energy absorption. 6. The device of claim 1, wherein the electronic assembly further comprises a current limiter configured to limit current from the resonator to enable reliable powerup. 7. The device of claim 1, wherein the coil and the capacitor configured to resonate at about 131 KHz+/−2%. 8. A leadless, implantable microstimulator device for treating chronic inflammation, the device comprising: a hermetically sealed capsule body;at least two electrically conductive capsule regions, wherein each region electrically connects to an electrode for applying stimulation to a vagus nerve;a resonator within the sealed capsule body, the resonator comprising a coil and a capacitor, the resonator comprising a coil and a capacitor configured to resonate at a predetermined frequency range;a thermistor positioned to monitor the temperature of an external surface of the capsule body;a battery within the sealed capsule body; andan electronic assembly within the sealed capsule body;wherein the electronic assembly comprises power management circuitry configured to receive power from the resonator to charge the battery, a microcontroller configured to control stimulation of the vagus nerve from the conductive capsule regions, and an overtemperature control configured to detune the resonator to reduce energy absorption when the thermistor measures a temperature exceeding a predetermined threshold temperature. 9. The device of claim 8, wherein the overtemperature control is configured to shut the device down if the operating temperature exceeds 41° C. 10. The device of claim 8, wherein the electronic assembly further comprises one or more voltage limiters to limit the amount of power that can charge the battery from the resonator. 11. The device of claim 8, wherein the electronic assembly further comprises a shorting switch configured to detune the resonator. 12. The device of claim 8, wherein the electronic assembly further comprises an overvoltage sensor configured to detune the resonator to reduce energy absorption. 13. The device of claim 8, further comprising a current limiter configured to limit current from the resonator to enable reliable powerup. 14. The device of claim 8, wherein the coil and the capacitor configured to resonate at about 131 KHz+/−2%. 15. A leadless, implantable microstimulator device for treating chronic inflammation, the device comprising: a hermetically sealed capsule body;at least two electrically conductive capsule regions, wherein each region electrically connects to an electrode for applying stimulation to a vagus nerve;a resonator within the sealed capsule body, the resonator comprising a coil and a capacitor configured to resonate at a predetermined frequency range;a first thermistor positioned to monitor the temperature of the coil and a second thermistor positioned to monitor the temperature of an external surface of the capsule body;a battery within the sealed capsule body; andan electronic assembly within the sealed capsule body;wherein the electronic assembly comprises power management circuitry configured to receive power from the resonator to charge the battery, a microcontroller configured to control stimulation of the vagus nerve from the conductive capsule regions, and an overtemperature control configured to detune the resonator to reduce energy absorption when either the first thermistor or the second thermistor measures a temperature exceeding a predetermined threshold temperature. 16. The device of claim 15, wherein the overtemperature control is configured to shut the device down if the operating temperature exceeds 41° C. 17. The device of claim 15, wherein the electronic assembly further comprises one or more voltage limiters to limit the amount of power that can charge the battery from the resonator. 18. The device of claim 15, wherein the electronic assembly further comprises a shorting switch configured to detune the resonator. 19. The device of claim 15, wherein the electronic assembly further comprises an overvoltage sensor configured to detune the resonator to reduce energy absorption.
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