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Amphiphilic triblock copolymers B-A-B, wherein A is a linear poly(ethylene glycol) block, having a number average molecular weight (Mn) of between 900 and 3000 Daltons, determined with size exclusion chromatography; wherein B are hydrophobic blocks with at least two cyclic monomers selected from the

Amphiphilic triblock copolymers B-A-B, wherein A is a linear poly(ethylene glycol) block, having a number average molecular weight (Mn) of between 900 and 3000 Daltons, determined with size exclusion chromatography; wherein B are hydrophobic blocks with at least two cyclic monomers selected from the group consisting of glycolide, lactide, 1,3-dioxan-2-one, 5,5-dimethyl-1,3-dioxan-2-one, 1,4-dioxan-2-one, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, each B-block having a number average molecular weight (Mn) of between 400 and 2000 Daltons, determined with size exclusion chromatography; and wherein 25% to 100% of the polymer hydroxyl end-groups are covalently modified with at least one derivative of a C2-C20 fatty acid. The invention also relates to compositions with such polymers and the use thereof.

대표청구항 ▼

1. An amphiphilic triblock copolymer B-A-B, wherein A is a linear poly(ethylene glycol) block having a number average molecular weight (Mn) of between 500 and 3000 Daltons, determined with size exclusion chromatography; wherein B are hydrophobic blocks comprising at least two cyclic monomers of glyc

1. An amphiphilic triblock copolymer B-A-B, wherein A is a linear poly(ethylene glycol) block having a number average molecular weight (Mn) of between 500 and 3000 Daltons, determined with size exclusion chromatography; wherein B are hydrophobic blocks comprising at least two cyclic monomers of glycolide, lactide, ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate(1,3-dioxan-2-one), 1,4-dioxepan-2-one (including its dimer 1,5,8,12-tetraoxacyclo-tetradecane-7,14-dione), 1,5-dioxepan-2-one, 6,6-dimethyl-1,4-dioxan-2-one, 2,5-diketomorpholine, pivalolactone, ε-diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, 6,8-dioxabicycloctane-7-one, β-propiolactone, γ-butyrolactone, δ-valerolactone, ε-decalactone, 3-methyl-1,4-dioxane-2,5-dione, 1,4-dioxane-2,5-dione, 2,5-diketo-morpholine, α,α-diethylpropiolactone, γ-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one, 6,8-dioxabicycloctane-7-one, or 5,5-dimethyl-1,3-dioxan-2-one, each B-block having a number average molecular weight (Mn) of between 400 and 3000 Daltons, determined with size exclusion chromatography; and wherein 25% to 100% of the polymer hydroxyl end-groups are covalently modified with at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid and wherein the B-blocks comprise monomer combinations comprising between 50 to 100 mol % 5,5-dimethyl-1,3-dioxan-2-one (also called 5,5-dimethyl trimethylene carbonate). 2. The amphiphilic triblock copolymer according to claim 1, wherein a block ratio, which is defined as a ratio between a sum of the number average molecular weight of the B-blocks and the number average molecular weight of the A-block, ranges between 0.5 and 3. 3. The amphiphilic triblock copolymer according to claim 1, wherein the number average molecular weight (Mn) of the linear poly(ethylene glycol) block ranges between 900 and 3000 Daltons. 4. The amphiphilic triblock copolymer according to claim 1, wherein the number average molecular weight (Mn) of each B-block ranges between 400 and 2000 Daltons. 5. The amphiphilic triblock copolymer according to claim 1, wherein the fatty acids derivatives used to modify the polymer hydroxyl end-groups are derivatives of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, alpha-linoleic acid, gamma-linoleic acid, stearidonic acid, rumenic acid, beta-calendic acid, eleostearic acid, puninic acid, parinaric acid, pinolenic acid, arachidic acid, eicosenoic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-gamma-linolenic acid, mead acid, eicosatetraenoic acid, arachidonic acid, or eicosapentaenoic acid. 6. The amphiphilic triblock copolymer according to claim 1, wherein at least 90% of the polymer hydroxyl end-groups are covalently modified with the at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid. 7. The amphiphilic triblock copolymer according to claim 2, wherein the number average molecular weight (Mn) of the linear poly(ethylene glycol) block ranges between 900 and 3000 Daltons, and wherein the number average molecular weight (Mn) of each B-block ranges between 400 and 2000 Daltons. 8. The amphiphilic triblock copolymer according to claim 7, wherein one of the cyclic monomers of the B-blocks is glycolide, lactide, ε-caprolactone or 1,3-dioxan-2-one; wherein the fatty acids derivatives used to modify the polymer hydroxyl end-groups are derivatives of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, alpha-linoleic acid, gamma-linoleic acid, stearidonic acid, rumenic acid, beta-calendic acid, eleostearic acid, puninic acid, parinaric acid, pinolenic acid, arachidic acid, eicosenoic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-gamma-linolenic acid, mead acid, eicosatetraenoic acid, arachidonic acid, or eicosapentaenoic acid; and wherein at least 90% of the polymer hydroxyl end-groups are covalently modified with the at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid. 9. An amphiphilic triblock copolymer B-A-B, wherein A is a linear poly(ethylene glycol) block having a number average molecular weight (Mn) of between 500 and 3000 Daltons, determined with size exclusion chromatography; wherein B are hydrophobic blocks comprising at least two cyclic monomers of glycolide, lactide, ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate(1,3-dioxan-2-one), 1,4-dioxepan-2-one (including its dimer 1,5,8,12-tetraoxacyclo-tetradecane-7,14-dione), 1,5-dioxepan-2one, 6,6-dimethyl-1,4-dioxan-2-one, 2,5-diketomorpholine, pivalolactone, chi. -diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, 6,8-dioxabicycloctane-7-one, β-propiolactone, γ-butyrolactone, δ-valerolactone, ε-decalactone, 3-methyl-1,4-dioxane-2,5-dione, 1,4-dioxane-2,5-dione, 2,5-diketo-morpholine, α,α-diethylpropiolactone,γ-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one, 6,8-dioxabicycloctane-7-one, or 5,5-dimethyl-1,3-dioxan-2-one, each B-block having a number average molecular weight (Mn) of between 400 and 3000 Daltons, determined with size exclusion chromatography; and wherein 25% to 100% of the polymer hydroxyl end-groups are covalently modified with at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid and wherein the B-blocks comprise monomer combinations comprising glycolide and at least one monomer that is 1,3-dioxan-2-one, 5,5-dimethyl-1,3-dioxan-2-one, 1,4-dioxan-2-one, 1,4-dioxepan-2-one, or 1,5-dioxepan-2-one. 10. The amphiphilic triblock copolymer according to claim 9, wherein a block ratio, which is defined as a ratio between a sum of the number average molecular weight of the B-blocks and the number average molecular weight of the A-block, ranges between 0.5 and 3. 11. The amphiphilic triblock copolymer according to claim 9, wherein the number average molecular weight (Mn) of the linear poly(ethylene glycol) block ranges between 900 and 3000 Daltons. 12. The amphiphilic triblock copolymer according to claim 9, wherein the number average molecular weight (Mn) of each B-block ranges between 400 and 2000 Daltons. 13. The amphiphilic triblock copolymer according to claim 10, wherein the number average molecular weight (Mn) of the linear poly(ethylene glycol) block ranges between 900 and 3000 Daltons and the number average molecular weight (Mn) of each B-block ranges between 400 and 2000 Daltons. 14. The amphiphilic triblock copolymer according to claim 9, wherein the fatty acids derivatives used to modify the polymer hydroxyl end-groups are derivatives of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, alpha-linoleic acid, gamma-linoleic acid, stearidonic acid, rumenic acid, beta-calendic acid, eleostearic acid, puninic acid, parinaric acid, pinolenic acid, arachidic acid, eicosenoic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-gamma-linolenic acid, mead acid, eicosatetraenoic acid, arachidonic acid or eicosapentaenoic acid. 15. The amphiphilic triblock copolymer according to claim 9, wherein at least 90% of the polymer hydroxyl end-groups are covalently modified with the at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid. 16. The amphiphilic triblock copolymer according to claim 13, wherein one of the cyclic monomers of the B-blocks is glycolide, lactide, ε-caprolactone or 1,3-dioxan-2one; wherein the fatty acids derivatives used to modify the polymer hydroxyl end-groups are derivatives of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, alpha-linoleic acid, gamma-linoleic acid, stearidonic acid, rumenic acid, beta-calendic acid, eleostearic acid, puninic acid, parinaric acid, pinolenic acid, arachidic acid, eicosenoic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-gamma-linolenic acid, mead acid, eicosatetraenoic acid, arachidonic acid or eicosapentaenoic acid and wherein at least 90% of the polymer hydroxyl end-groups are covalently modified with the at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid. 17. An amphiphilic triblock copolymer B-A-B, wherein A is a linear poly(ethylene glycol) block having a number average molecular weight (Mn) of between 500 and 3000 Daltons, determined with size exclusion chromatography; wherein B are hydrophobic blocks comprising at least two cyclic monomers of glycolide, lactide, ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate(1,3-dioxan-2-one), 1,4-dioxepan-2-one (including its dimer 1,5,8,12-tetraoxacyclo-tetradecane-7,14-dione), 1,5-dioxepan-2-one, 6,6-dimethyl-1,4-dioxan-2-one, 2,5-diketomorpholine, pivalolactone, chi. -diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, 6,8-dioxabicycloctane-7-one, β-propiolactone, γ-butyrolactone, δ-valerolactone, ε-decalactone, 3-methyl-1,4-dioxane-2,5-dione, 1,4-dioxane-2,5-dione, 2,5-diketo-morpholine, α,α-diethylpropiolactone,γ-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one, 6,8-dioxabicycloctane-7-one, or 5,5-dimethyl-1,3-dioxan-2-one, each B-block having a number average molecular weight (Mn) of between 400 and 3000 Daltons, determined with size exclusion chromatography; and wherein 25% to 100% of the polymer hydroxyl end-groups are covalently modified with at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid and wherein the B-blocks comprise monomer combinations comprising lactide and at least one monomer that is 1,3-dioxan-2-one, 5,5-dimethyl-1,3-dioxan-2-one, 1,4-dioxan-2-one, 1,4-dioxepan-2-one, or 1,5-dioxepan-2-one. 18. The amphiphilic triblock copolymer according to claim 17, wherein a block ratio, which is defined as a ratio between a sum of the number average molecular weight of the B-blocks and the number average molecular weight of the A-block, ranges between 0.5 and 3. 19. The amphiphilic triblock copolymer according to claim 17, wherein the number average molecular weight (Mn) of the linear poly(ethylene glycol) block ranges between 900 and 3000 Daltons. 20. The amphiphilic triblock copolymer according to claim 17, wherein the number average molecular weight (Mn) of each B-block ranges between 400 and 2000 Daltons. 21. The amphiphilic triblock copolymer according to claim 18, wherein the number average molecular weight (Mn) of the linear poly(ethylene glycol) block ranges between 900 and 3000 Daltons and the number average molecular weight (Mn) of each B-block ranges between 400 and 2000 Daltons. 22. The amphiphilic triblock copolymer according to claim 17, wherein the fatty acids derivatives used to modify the polymer hydroxyl end-groups are derivatives of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, alpha-linoleic acid, gamma-linoleic acid, stearidonic acid, rumenic acid, beta-calendic acid, eleostearic acid, puninic acid, parinaric acid, pinolenic acid, arachidic acid, eicosenoic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-gamma-linolenic acid, mead acid, eicosatetraenoic acid, arachidonic acid or eicosapentaenoic acid. 23. The amphiphilic triblock copolymer according to claim 17, wherein at least 90% of the polymer hydroxyl end-groups are covalently modified with the at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid. 24. The amphiphilic triblock copolymer according to claim 21, wherein one of the cyclic monomers of the B-blocks is glycolide, lactide, ε-caprolactone or 1,3-dioxan-2-one; wherein the fatty acids derivatives used to modify the polymer hydroxyl end-groups are derivatives of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, alpha-linoleic acid, gamma-linoleic acid, stearidonic acid, rumenic acid, beta-calendic acid, eleostearic acid, puninic acid, parinaric acid, pinolenic acid, arachidic acid, eicosenoic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-gamma-linolenic acid, mead acid, eicosatetraenoic acid, arachidonic acid or eicosapentaenoic acid and wherein at least 90% of the polymer hydroxyl end-groups are covalently modified with the at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid. 25. An amphiphilic triblock copolymer B-A-B, wherein A is a linear poly(ethylene glycol) block having a number average molecular weight (Mn) of between 500 and 3000 Daltons, determined with size exclusion chromatography; wherein B are hydrophobic blocks comprising at least two cyclic monomers of glycolide, lactide, ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate(1,3-dioxan-2-one), 1,4-dioxepan-2-one (including its dimer 1,5,8,12-tetraoxacyclo-tetradecane-7,14-dione), 1,5-dioxepan-2-one, 6,6-dimethyl-1,4-dioxan-2-one, 2,5-diketomorpholine, pivalolactone, chi. -diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, 6,8-dioxabicycloctane-7-one, β-propiolactone, γ-butyrolactone, δ-valerolactone, ε-decalactone, 3-methyl-1,4-dioxane-2,5-dione, 1,4-dioxane-2,5-dione, 2,5-diketo-morpholine, α,α-diethylpropiolactone,γ-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one, 6,8-dioxabicycloctane-7-one, or 5,5-dimethyl-1,3-dioxan-2-one, each B-block having a number average molecular weight (Mn) of between 400 and 3000 Daltons, determined with size exclusion chromatography; and wherein 25% to 100% of the polymer hydroxyl end-groups are covalently modified with at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid and wherein the B-blocks comprise monomer combinations comprising 1,3-dioxan-2one and at least one monomer that is 5,5-dimethyl-1,3-dioxan-2-one, 1,4-dioxan-2-one, 1,4-dioxepan-2-one, or 1,5-dioxepan-2-one. 26. The amphiphilic triblock copolymer according to claim 25, wherein a block ratio, which is defined as a ratio between a sum of the number average molecular weight of the B-blocks and the number average molecular weight of the A-block, ranges between 0.5 and 3. 27. The amphiphilic triblock copolymer according to claim 25, wherein the number average molecular weight (Mn)of the linear poly(ethylene glycol) block ranges between 900 and 3000 Daltons. 28. The amphiphilic triblock copolymer according to claim 25, wherein the number average molecular weight (Mn) of each B-block ranges between 400 and 2000 Daltons. 29. The amphiphilic triblock copolymer according to claim 26, wherein the number average molecular weight (Mn) of the linear poly(ethylene glycol) block ranges between 900 and 3000 Daltons and the number average molecular weight (Mn) of each B-block ranges between 400 and 2000 Daltons. 30. The amphiphilic triblock copolymer according to claim 25, wherein the fatty acids derivatives used to modify the polymer hydroxyl end-groups are derivatives of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, alpha-linoleic acid, gamma-linoleic acid, stearidonic acid, rumenic acid, beta-calendic acid, eleostearic acid, puninic acid, parinaric acid, pinolenic acid, arachidic acid, eicosenoic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-gamma-linolenic acid, mead acid, eicosatetraenoic acid, arachidonic acid or eicosapentaenoic acid. 31. The amphiphilic triblock copolymer according to claim 25, wherein at least 90% of the polymer hydroxyl end-groups are covalently modified with the at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid. 32. The amphiphilic triblock copolymer according to claim 29, wherein one of the cyclic monomers of the B-blocks is glycolide, lactide, ε-caprolactone or 1,3-dioxan-2-one; wherein the fatty acids derivatives used to modify the polymer hydroxyl end-groups are derivatives of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, alpha-linoleic acid, gamma-linoleic acid, stearidonic acid, rumenic acid, beta-calendic acid, eleostearic acid, puninic acid, parinaric acid, pinolenic acid, arachidic acid, eicosenoic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-gamma-linolenic acid, mead acid, eicosatetraenoic acid, arachidonic acid or eicosapentaenoic acid and wherein at least 90% of the polymer hydroxyl end-groups are covalently modified with the at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid. 33. An amphiphilic triblock copolymer B-A-B, wherein A is a linear poly(ethylene glycol) block having a number average molecular weight (Mn) of between 500 and 3000 Daltons, determined with size exclusion chromatography; wherein B are hydrophobic blocks comprising at least two cyclic monomers of glycolide, lactide ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate(1,3-dioxan-2-one), 1,4-dioxepan-2-one (including its dimer 1,5,8,12-tetraoxacyclo-tetradecane-7,14-dione), 1,5-dioxepan-2-one, 6,6-dimethyl-1,4-dioxan-2-one, 2,5-diketomorpholine, pivalolactone, chi. diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, 6,8-dioxabicycloctane-7-one, β-propiolactone, γ-butyrolactone, δ-valerolactone, ε-decalactone, 3-methyl-1,4-dioxane-2,5-dione, 1,4-dioxane -2,5-dione, 2,5-diketomorpholine, α,α-diethylpropiolactone,γ-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one, 6,8-dioxabicycloctane-7-one or 5,5-dimethyl-1,3-dioxan-2-one, each B-block having a number average molecular weight (Mn) of between 400 and 3000 Daltons, determined with size exclusion chromatography; and wherein 25% to 100% of the polymer hydroxyl end-groups are covalently modified with at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid and wherein the B-blocks comprise monomer combinations comprising ε-caprolactone and at least one monomer that is 1,3-dioxan-2-one, 5,5-dimethyl-1,3-dioxan-2-one, 1,4-dioxan-2-one, 1,4-dioxepan-2-one, or 1,5-dioxepan-2-one. 34. The amphiphilic triblock copolymer according to claim 33, wherein a block ratio, which is defined as a ratio between a sum of the number average molecular weight of the B-blocks and the number average molecular weight of the A-block, ranges between 0.5 and 3. 35. The amphiphilic triblock copolymer according to claim 33, wherein the number average molecular weight (Mn) of the linear poly(ethylene glycol) block ranges between 900 and 3000 Daltons. 36. The amphiphilic triblock copolymer according to claim 33, wherein the number average molecular weight (Mn) of each B-block ranges between 400 and 2000 Daltons. 37. The amphiphilic triblock copolymer according to claim 34, wherein the number average molecular weight (Mn) of the linear poly(ethylene glycol) block ranges between 900 and 3000 Daltons and the number average molecular weight (Mn) of each B-block ranges between 400 and 2000 Daltons. 38. The amphiphilic triblock copolymer according to claim 33, wherein the fatty acids derivatives used to modify the polymer hydroxyl end-groups are derivatives of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, alpha-linoleic acid, gamma-linoleic acid, stearidonic acid, rumenic acid, beta-calendic acid, eleostearic acid, puninic acid, parinaric acid, pinolenic acid, arachidic acid, eicosenoic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-gamma-linolenic acid, mead acid, eicosatetraenoic acid, arachidonic acid or eicosapentaenoic acid. 39. The amphiphilic triblock copolymer according to claim 21, wherein at least 90% of the polymer hydroxyl end-groups are covalently modified with the at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid. 40. The amphiphilic triblock copolymer according to claim 37, wherein one of the cyclic monomers of the B-blocks is glycolide, lactide, ε-caprolactone or 1,3-dioxan-2-one; wherein the fatty acids derivatives used to modify the polymer hydroxyl end-groups are derivatives of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, alpha-linoleic acid, gamma-linoleic acid, stearidonic acid, rumenic acid, beta-calendic acid, eleostearic acid, puninic acid, parinaric acid, pinolenic acid, arachidic acid, eicosenoic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-gamma-linolenic acid, mead acid, eicosatetraenoic acid, arachidonic acid or eicosapentaenoic acid and wherein at least 90% of the polymer hydroxyl end-groups are covalently modified with the at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid. 41. An amphiphilic triblock copolymer B-A-B, wherein A is a linear poly(ethylene glycol) block having a number average molecular weight (Mn) of between 500 and 3000 Daltons, determined with size exclusion chromatography; wherein B are hydrophobic blocks comprising at least two cyclic monomers of glycolide, lactide, ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate(1,3-dioxan-2-one), 1,4-dioxepan-2-one (including its dimer 1,5,8,12-tetraoxacyclo-tetradecane-7,14-dione), 1,5-dioxepan-2-one, 6,6-dimethyl-1,4-dioxan-2-one, 2,5-diketomorpholine, pivalolactone, chi. -diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, 6,8-dioxabicycloctane-7-one, β-propiolactone, γ-butyrolactone, δ-valerolactone, ε-decalactone, 3-methyl-1,4-dioxane-2,5-dione, 1,4-dioxane 2,5-dione, 2,5-diketo-morpholine, α,α-diethylpropiolactone,γ-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one, 6,8-dioxabicycloctane-7-one, or 5,5-dimethyl-1,3-dioxan-2-one, each B-block having a number average molecular weight (Mn) of between 400 and 3000 Daltons, determined with size exclusion chromatography; and wherein 25% to 100% of the polymer hydroxyl end-groups are covalently modified with at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid and wherein the B-blocks comprise monomer combinations consisting of between 50 to 100 mol% glycolide; and caprolactone as a second monomer. 42. The amphiphilic triblock copolymer according to claim 41, wherein a block ratio, which is defined as a ratio between a sum of the number average molecular weight of the B-blocks and the number average molecular weight of the A-block, ranges between 0.5 and 3. 43. The amphiphilic triblock copolymer according to claim 41, wherein the number average molecular weight (Mn) of the linear poly(ethylene glycol) block ranges between 900 and 3000 Daltons. 44. The amphiphilic triblock copolymer according to claim 41, wherein the number average molecular weight (Mn) of each B-block ranges between 400 and 2000 Daltons. 45. The amphiphilic triblock copolymer according to claim 42, wherein the number average molecular weight (Mn) of the linear poly(ethylene glycol) block ranges between 900 and 3000 Daltons and the number average molecular weight (Mn) of each B-block ranges between 400 and 2000 Daltons. 46. The amphiphilic triblock copolymer according to claim 41, wherein the fatty acids derivatives used to modify the polymer hydroxyl end-groups are derivatives of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, alpha-linoleic acid, gamma-linoleic acid, stearidonic acid, rumenic acid, beta-calendic acid, eleostearic acid, puninic acid, parinaric acid, pinolenic acid, arachidic acid, eicosenoic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-gamma-linolenic acid, mead acid, eicosatetraenoic acid, arachidonic acid or eicosapentaenoic acid. 47. The amphiphilic triblock copolymer according to claim 41, wherein at least 90% of the polymer hydroxyl end-groups are covalently modified with the at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid. 48. The amphiphilic triblock copolymer according to claim 45, wherein one of the cyclic monomers of the B-blocks is glycolide, lactide, ε-caprolactone or 1,3-dioxan-2- -one; wherein the fatty acids derivatives used to modify the polymer hydroxyl end-groups are derivatives of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, alpha-linoleic acid, gamma-linoleic acid, stearidonic acid, rumenic acid, beta-calendic acid, eleostearic acid, puninic acid, parinaric acid, pinolenic acid, arachidic acid, eicosenoic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-gamma-linolenic acid, mead acid, eicosatetraenoic acid, arachidonic acid or eicosapentaenoic acid and wherein at least 90% of the polymer hydroxyl end-groups are covalently modified with the at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid. 49. An amphiphilic triblock copolymer B-A-B, wherein A is a linear poly(ethylene glycol) block having a number average molecular weight (Mn) of between 500 and 3000 Daltons, determined with size exclusion chromatography; wherein B are hydrophobic blocks comprising at least two cyclic monomers of glycolide, lactide, ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate(1,3-dioxan-2-one), 1,4-dioxepan-2-one (including its dimer 1,5,8,12-tetraoxacyclo-tetradecane-7,14-dione), 1,5-dioxepan-2-one, 6,6-dimethyl-1,4-dioxan-2-one, 2,5-diketomorpholine, pivalolactone, chi. -diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, 6,8-dioxabicycloctane-7-one, β-propiolactone, γ-butyrolactone, δ-valerolactone, ε-decalactone, 3-methyl-1,4-dioxane-2,5-dione, 1,4-dioxane -2,5-dione, 2,5-diketo-morpholine, α,α-diethylpropiolactone,γ-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one, 6,8-dioxabicycloctane-7-one, or 5,5-dimethyl-1,3-dioxan-2-one, each B-block having a number average molecular weight (Mn) of between 400 and 3000 Daltons, determined with size exclusion chromatography; and wherein 25% to 100% of the polymer hydroxyl end-groups are covalently modified with at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid and wherein the B-blocks comprise monomer combinations comprising between 50 to 100 mol% trimethylene carbonate. 50. The amphiphilic triblock copolymer according to claim 49, wherein a block ratio, which is defined as a ratio between a sum of the number average molecular weight of the B-blocks and the number average molecular weight of the A-block, ranges between 0.5 and 3. 51. The amphiphilic triblock copolymer according to claim 49, wherein the number average molecular weight (Mn) of the linear poly(ethylene glycol) block ranges between 900 and 3000 Daltons. 52. The amphiphilic triblock copolymer according to claim 49, wherein the number average molecular weight (Mn) of each B-block ranges between 400 and 2000 Daltons. 53. The amphiphilic triblock copolymer according to claim 49, wherein the number average molecular weight (Mn) of the linear poly(ethylene glycol) block ranges between 900 and 3000 Daltons and the number average molecular weight (Mn) of each B-block ranges between 400 and 2000 Daltons. 54. The amphiphilic triblock copolymer according to claim 50, wherein the fatty acids derivatives used to modify the polymer hydroxyl end-groups are derivatives of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, alpha-linoleic acid, gamma-linoleic acid, stearidonic acid, rumenic acid, beta-calendic acid, eleostearic acid, puninic acid, parinaric acid, pinolenic acid, arachidic acid, eicosenoic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-gamma-linolenic acid, mead acid, eicosatetraenoic acid, arachidonic acid or eicosapentaenoic acid. 55. The amphiphilic triblock copolymer according to claim 49, wherein at least 90% of the polymer hydroxyl end-groups are covalently modified with the at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid. 56. The amphiphilic triblock copolymer according to claim 53, wherein one of the cyclic monomers of the B-blocks is glycolide, lactide, ε-caprolactone or 1,3-dioxan-2-one; wherein the fatty acids derivatives used to modify the polymer hydroxyl end-groups are derivatives of caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, alpha-linoleic acid, gamma-linoleic acid, stearidonic acid, rumenic acid, beta-calendic acid, eleostearic acid, puninic acid, parinaric acid, pinolenic acid, arachidic acid, eicosenoic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-gamma-linolenic acid, mead acid, eicosatetraenoic acid, arachidonic acid or eicosapentaenoic acid and wherein at least 90% of the polymer hydroxyl end-groups are covalently modified with the at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid.