Isolation of a dual COX-2 and 5-lipdxygenase inhibitor from Acacia
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A01N-065/00
A61K-031/353
A61K-036/00
A61K-031/33
A61K-036/48
출원번호
US-0971514
(2013-08-20)
등록번호
US-9168242
(2015-10-27)
발명자
/ 주소
Jia, Qi
Nichols, Timothy C.
Rhoden, Eric E.
Waite, Scott
출원인 / 주소
Unigen, Inc.
대리인 / 주소
Seed IP Law Group PLLC
인용정보
피인용 횟수 :
0인용 특허 :
78
초록▼
The present disclosure provides compositions and methods for alleviating inflammatory-associated diseases and conditions. These methods include administering individual and/or a mixture of multiple flavans isolated from a single or multiple Acacia genus of plants. The present disclosure also include
The present disclosure provides compositions and methods for alleviating inflammatory-associated diseases and conditions. These methods include administering individual and/or a mixture of multiple flavans isolated from a single or multiple Acacia genus of plants. The present disclosure also includes methods for isolating and purifying from an Acacia genus of plants a composition of flavans having dual specificity for cyclooxygenase (COX-2) and 5-lipoxygenase (5-LO) enzymes.
대표청구항▼
1. A method for reducing joint discomfort, comprising administering to a human or non-human animal having joint discomfort a therapeutically effective amount of a composition comprising an Acacia extract enriched for flavans containing catechin and/or epicatechin, wherein the method alleviates cyclo
1. A method for reducing joint discomfort, comprising administering to a human or non-human animal having joint discomfort a therapeutically effective amount of a composition comprising an Acacia extract enriched for flavans containing catechin and/or epicatechin, wherein the method alleviates cyclooxygenase and 5-lipoxygenase mediated inflammation in the human or non-human animal having joint discomfort. 2. The method according to claim 1, wherein the Acacia is selected from the group consisting of Acacia catechu, Acacia concinna, Acacia famesiana, Acacia senegal, Acacia speciosa, Acacia arabica, Acacia caesia, Acacia pennata, Acacia sinuata, Acacia meamsii, Acacia picnantha, Acacia dealbata, Acacia auriculiformis, Acacia holoserecia, and Acacia mangium. 3. The method according to claim 1, wherein the extract is from an Acacia plant part selected from the group consisting of stems, stem barks, trunks, trunk barks, twigs, tubers, roots, root barks, young shoots, seeds, rhizomes, flowers, and leaves. 4. The method according to claim 1, wherein the cyclooxygenase and 5-lipoxygenase mediated inflammation is osteoarthritis, rheumatoid arthritis, or systemic lupus erythematosis. 5. The method according to claim 1, wherein the Acacia extract is comprised of 0.01% to 100% of flavans. 6. The method according to claim 1, wherein the Acacia extract is administered at a dose of 0.01 to 200 mg/kg of body weight of the human or non-human animal. 7. The method according to claim 1, wherein the route of the administration is selected from the group consisting of oral, topical, suppository, intravenous, intradermic, intragaster, intramusclar, intraperitoneal, and intravenous. 8. The method according to claim 1, wherein the extract is comprised of at least 14.83% catechin and epicatechin.
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