Methods and compositions for promoting wound healing
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/198
A61K-031/133
A61K-033/38
A61K-045/06
A61L-026/00
출원번호
US-0711224
(2015-05-13)
등록번호
US-9173972
(2015-11-03)
발명자
/ 주소
Wooley, Richard E.
Ritchie, Branson W.
Kemp, Douglas T.
Capomacchia, Anthony C.
Burnley, Victoria V.
출원인 / 주소
Wooley, Richard E.
대리인 / 주소
Lowder, Patrick D.
인용정보
피인용 횟수 :
0인용 특허 :
55
초록▼
The present invention provides methods and compositions that use the combination of Tris and EDTA to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amoun
The present invention provides methods and compositions that use the combination of Tris and EDTA to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amount of Tris and EDTA applied to a wound or burn can be selected to achieve one or more of the foregoing effects.
대표청구항▼
1. A method of promoting healing of a burn on a mammalian, bird, or reptile body in need thereof, the method comprising applying to said burn an amount of a composition consisting of Tris, EDTA, and dissolved silver in a pharmaceutically acceptable carrier selected from the group consisting of water
1. A method of promoting healing of a burn on a mammalian, bird, or reptile body in need thereof, the method comprising applying to said burn an amount of a composition consisting of Tris, EDTA, and dissolved silver in a pharmaceutically acceptable carrier selected from the group consisting of water, saline, physiological saline, an ointment, a cream, an oil-water emulsion, and a gel, wherein the silver, Tris, and EDTA are in amounts sufficient to promote healing of a burn on a mammalian, bird, or reptile body, the composition consisting of a pH of from 6.0 to 9.0, and optionally, a detergent, a vitamin, an anti-inflammatory agent, lecithin, glycerin, methyl paraben, aloe vera, polypropylene glycol ethoxylate, and/or poloxamer 407, effective to promote healing therefor. 2. A method of promoting healing of a wound in, or on, a living mammalian, bird, or reptile body in need thereof, the method comprising applying to or in said wound an amount of a composition consisting of Tris, EDTA, and dissolved silver in a pharmaceutically acceptable carrier selected from the group consisting of water, saline, physiological saline, an ointment, a cream, an oil-water emulsion, and a gel, wherein the silver, Tris, and EDTA are in amounts sufficient to promote healing of a burn on a mammalian, bird, or reptile body, the composition consisting of a pH of from 6.0 to 9.0, and optionally, a detergent, a vitamin, an anti-inflammatory agent, lecithin, glycerin, methyl paraben, aloe vera, polypropylene glycol ethoxylate, and/or poloxamer 407, effective to promote healing therefor. 3. A method of treating a burn in a human subject in need thereof comprising administering to the human subject a therapeutically effective amount of a composition consisting of Tris, EDTA, and dissolved silver in a pharmaceutically acceptable carrier selected from the group consisting of water, saline, physiological saline, an ointment, a cream, an oil-water emulsion, and a gel, wherein the silver, Tris, and EDTA are in amounts sufficient to promote healing of a burn on a mammalian, bird, or reptile body, the composition having consisting of a pH of from 6.0 to 9.0, and optionally, a detergent, a vitamin, an anti-inflammatory agent, lecithin, glycerin, methyl paraben, aloe vera, polypropylene glycol ethoxylate, and/or poloxamer 407, effective to promote healing therefor. 4. A method of treating a wound in a human subject in need thereof comprising administering to the human subject a therapeutically effective amount of a composition consisting of Tris, EDTA, and dissolved silver in a pharmaceutically acceptable carrier selected from the group consisting of water, saline, physiological saline, an ointment, a cream, an oil-water emulsion, and a gel, wherein the silver, Tris, and EDTA are in amounts sufficient to promote healing of a burn on a mammalian, bird, or reptile body, the composition consisting of a pH of from 6.0 to 9.0, and optionally, a detergent, a vitamin, an anti-inflammatory agent, lecithin, glycerin, methyl paraben, aloe vera, polypropylene glycol ethoxylate, and/or poloxamer 407, effective to promote healing therefor. 5. The method according to claim 2 wherein the wound is an ulcer. 6. The method according to claim 4 wherein the wound is an ulcer. 7. The method according to claim 2 wherein the wound is colonized by a bacterium selected from the group consisting of: Aerobacter spp.; Aeromonas spp.; Bacillus spp.; Bordetella spp; Campylobacter spp.; Chlamydia spp.; Corynebacterium spp.; Escherichia spp., Helicobacter pylori; Klebsiella pneumoniae; Legionella pneumophiia; Leptospira spp.; Mycobacterium spp.; Neisseria spp.; Nocardia spp.; Proteus spp.; Pseudomonas aeruginosa; Rhodococcus equi, Salmonella spp.; Shigella spp.; Staphylococcus spp.; Streptococcus spp.; Vibrio spp.; Yersinia spp.; Actinomycetes spp.; Propionibacterium spp.; and Streptomyces spp. 8. The method according to claim 4 wherein the wound is colonized by a bacterium selected from the group consisting of: Aerobacter spp.; Aeromonas spp.; Bacillus spp.; Bordetella spp; Campylobacter spp.; Chlamydia spp.; Corynebacterium spp.; Escherichia spp., Helicobacter pylori; Klebsiella pneumoniae; Legionella pneumophiia; Leptospira spp.; Mycobacterium spp.; Neisseria spp.; Nocardia spp.; Proteus spp.; Pseudomonas aeruginosa; Rhodococcus equi, Salmonella spp.; Shigella spp.; Staphylococcus spp.; Streptococcus spp.; Vibrio spp.; Yersinia spp.; Actinomycetes spp.; Propionibacterium spp.; and Streptomyces spp. 9. The method according to claim 2 wherein the wound is colonized by a fungus selected from the group consisting of Aspergillus spp., Fusarium spp., Mucor spp., Penicillium spp., Trichophyton spp., Microsporum spp., Candida spp., Malessizia spp., Psuedallescheria spp., Paecilomyces spp., Scedosporium spp and Dematiaceous fungi. 10. The method according to claim 4 wherein the wound is colonized by a fungus selected from the group consisting of Aspergillus spp., Fusarium spp., Mucor spp., Penicillium spp., Trichophyton spp., Microsporum spp., Candida spp., Malessizia spp., Psuedallescheria spp., Paecilomyces spp., Scedosporium spp and Dematiaceous fungi.
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