$\require{mediawiki-texvc}$
  • 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색도움말
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"

통합검색

도움말도움말
상세검색 다국어 입력

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

특허 상세정보

MyON담기
내보내기 페이스북 공유 카카오톡 공유

Polymeric tissue sealant

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-031/74    A61L-024/04    A61L-031/06    C08G-065/332    C08G-065/333    C08G-065/334    C08L-071/02    A61L-024/00    C08G-063/00    A61K-047/34   
출원번호 US-0598786 (2015-01-16)
등록번호 US-9180222 (2015-11-10)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    Pabst Patent Group LLP
인용정보 피인용 횟수 : 0  인용 특허 : 91
초록
▼

Methods for making biomaterials for use as a tissue sealant, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from a composition comprising at least a first and a second precursor molecule, wherein: i) the first precursor molecule is a poly(ethylene glycol) based polymer having x nucleophilic groups selected from the group consisting of thiol or amino groups, wherein x is greater than or equal to 2ii) the second precursor molecule is of the general formula: A-(C3H6O)...

대표
청구항
▼

1. A kit comprising: i) a poly(ethylene oxide) molecule comprising x nucleophilic groups selected from the group consisting of thiol and amino groups, wherein x is greater than or equal to 2; andii) a molecule of general formula: A-[(C3H6O)n-(C2H4O)m-B]iwherein m and n are integers from 1 to 200;i is greater than 2;A is a branch point; andB is a conjugated unsaturated group. 2. The kit of claim 1, further comprising a basic solution. 3. The kit of claim 2, wherein the basic solution comprises sodium carbonate. 4. The kit of claim 1, further comprising a ...

이 특허에 인용된 특허 (91)

  1. Andrew T. C. Liu. Abrasion resistant dental composition product and process. USP2002056384107.
  2. Barrows Thomas H. (Cottage Grove MN) Lewis Terry W. (Woodbury MN) Truong Myhanh T. (Blaine MN). Adhesive sealant composition. USP1996125583114.
  3. Schroeder Jacqueline A. (Redwood City CA) Bentz Hanne (Newark CA) Estridge Trudy D. (Fremont CA). Affinity bound collagen matrices for the delivery of biologically active agents. USP1997125693341.
  4. Krstenansky John L. ; Nestor John J. ; Ho Teresa H.. Analogs of parathyroid hormone and parathyroid hormone relate peptide synthesis and use for the treatment of osteoporos. USP1998115840837.
  5. Reed Guy L. (Winchester MA) Haber Edgar (Salisbury NH) Matsueda Gary R. (Princeton NJ). Antibodies that bind to a
  6. Greenwald Richard B. (Somerset NJ). Azlactone activated polyalkylene oxides conjugated to biologically active nucleophiles. USP1996105567422.
  7. Capecchi John T. (Oakdale MN) Heilmann Steven M. (Afton MN) Krepski Larry R. (White Bear Lake MN) Kwon Oh-Seung (Woodbury MN) Olson David B. (May Township ; County of Washington MN). Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof. USP1994035292514.
  8. Marra Kacey G. ; Weiss Lee E. ; Calvert Jay Wynn ; Kumta Prashant N.. Biocompatible compositions and methods of using same. USP2000126165486.
  9. Rhee,Woonza M.; DeLustro,Frank A.; Berg,Richard A.. Biocompatible crosslinked composition. USP2007027176256.
  10. Pathak, Chandrashekhar P.; Sawhney, Amarpreet S.; Edelman, Peter G.. Biocompatible crosslinked polymers. USP2003056566406.
  11. Pathak,Chandrashekhar P.; Sawhney,Amarpreet S.; Edelman,Peter G.. Biocompatible crosslinked polymers. USP2006037009034.
  12. Pathak,Chandrashekhar P.; Sawhney,Amarpreet S.; Edelman,Peter G.. Biocompatible crosslinked polymers with visualization agents. USP2008027332566.
  13. Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark . Biologically inert, biocompatible-polymer conjugates. USP1994065324775.
  14. Hubbell, Jeffrey A.; Elbert, Donald; Lütolf, Matthias; Pratt, Alison; Schoenmakers, Ronald; Tirelli, Nicola; Vernon, Brent. Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups. USP2010067744912.
  15. Scheicher Hans (Rondell Neuwittelsbach 4 8000 Mnchen 19 DEX) Wendler Eberhard (Sedelhofstr. 3 8000 Mnchen 60 DEX). Bone replacement material on the basis of carbonate and alkali containing calciumphosphate apatites. USP1990044917702.
  16. Kilburn Douglas G. (Vancouver) Miller Robert C. (Vancouver) Warren Richard A. J. (Vancouver) Gilkes Neil R. (Vancouver CAX). Cellulose binding fusion proteins having a substrate binding region of cellulase. USP1993045202247.
  17. Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark . Collagen-polymer conjugates. USP1995055413791.
  18. Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark . Collagen-polymer conjugates. USP1992115162430.
  19. Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark . Collagen-polymer conjugates. USP1994075328955.
  20. Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA). Collagen-synthetic polymer matrices prepared using a multiple step reaction. USP1995125475052.
  21. Kilburn Douglas G.,CAX ; Humphries Keith R.,CAX ; Doheny James G.,CAX ; Jervis Eric,CAX ; Alimonti Judie,CAX. Compositions and methods for modulating cell proliferation using growth factor-polysaccharide binding fusion proteins. USP1999025874308.
  22. Daniloff,George Y.; Daniels,John R.. Compositions and methods of using a transient colorant. USP2007097273896.
  23. Olof Mikael Trollsas ; Donald G. Wallace ; Frank A. DeLustro. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use. USP2002106458889.
  24. Lee,John C.; Yeh,Lee Chuan C.. Compositions and therapeutic methods using morphogenic proteins and stimulatory factors. USP2006047026292.
  25. Molenberg, Aaldert Rens; Fehr, Daniel; Zamparo, Enrico. Compositions for tissue augmentation. USP2009087575740.
  26. Oldenburg Kevin R. ; Selick Harold E.. Compounds with PTH activity. USP1998095814603.
  27. Hubbell, Jeffrey A.; Elbert, Donald L.; Schoenmakers, Ronald. Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds. USP2010037670605.
  28. Hubbell, Jeffrey A.; Elbert, Donald; Schoenmakers, Ronald. Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds. USP2005106958212.
  29. Hubbell,Jeffrey A.; Elbert,Donald; Schoenmakers,Ronald. Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds. USP2007117291673.
  30. Hubbell,Jeffrey A.; Elbert,Donald; Schoenmakers,Ronald. Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds. USP2008087413739.
  31. Larsson Rolf (Uppsala SEX) Westberg David (Uppsala SEX) Formgren Birgitta (Uppsala SEX) Uhlin Anders (Uppsala SEX). Conjugate, its preparation and use and a substrate prepared with the conjugate. USP1996065529986.
  32. Shadle Paula J. (Richmond CA) Koths Kirston E. (El Cerrito CA) Moreland Margaret (Berkeley CA) Katre Nandini (El Cerrito CA). Conjugation of polymer to colony stimulating factor-1. USP1989074847325.
  33. Chorev Michael ; Rosenblatt Michael. Continuous low-dose administration of parathyroid hormone or its agonist. USP1998055747456.
  34. Edelman Elazer R. (Brookline MA) Langer Robert S. (Somerville MA) Klagsburn Michael (Newton MA) Mathiowitz Edith (Brookline MA). Controlled release systems containing heparin and growth factors. USP1992035100668.
  35. Rhee, Woonza M.; DeLustro, Frank A.; Berg, Richard A.. Cross-linked polymer compositions and methods for their use. USP2003036534591.
  36. Rhee Woonza M. ; DeLustro Frank A. ; Berg Richard A.. Crosslinked polymer compositions and methods for their use. USP2000046051648.
  37. Rhee Woonza M. ; DeLustro Frank A. ; Berg Richard A.. Crosslinked polymer compositions and methods for their use. USP1999025874500.
  38. Pathak, Chandrashekhar P.. Crosslinking agents and methods of use. USP2005056887974.
  39. Kehr Clifton L. (Silver Spring MD). Curable liquid polymer compositions. USP1977024008341.
  40. Harris J. Milton. Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels. USP2001076258351.
  41. Hubbell Jeffrey A.,CHX ; Schense Jason,CHX. Enzyme-mediated modification of fibrin for tissue engineering. USP2001126331422.
  42. Hubbell,Jeffrey A.; Schense,Jason C.; Sakiyama,Shelly E.. Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides. USP2007077241730.
  43. Hubbell, Jeffrey A.; Schense, Jason C.; Sakiyama, Shelly E.. Enzyme-mediated modification of fibrin for tissue engineering: incorporation of proteins. USP2005116960452.
  44. Jeffrey A. Hubbell CH; Jason C. Schense CH; Shelly E. Sakiyama CH. Enzyme-mediated modification of fibrin for tissue engineering: incorporation of proteins. USP2002106468731.
  45. Tucker Harold A. (Shaker Heights OH). Fast-curling, high strength, two-part sealants using acetoacetate-amine cure chemistry. USP1995065426148.
  46. Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill-West Jennifer L. (Austin TX) Hossainy Syed F. A. (Austin TX). Gels for encapsulation of biological materials. USP1996115573934.
  47. Hubbell Jeffrey A. (Concord MA) Pathak Chandrashekhar P. (Austin TX) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hossainy Syed F. A. (Austin TX). Gels for encapsulation of biological materials. USP1996065529914.
  48. Hubbell, Jeffrey A.; Schense, Jason C.; Sakiyama-Elbert, Shelly E.. Growth factor modified protein matrices for tissue engineering. USP2005056894022.
  49. L？tolf,Matthias; Schense,Jason; Hubbell,Jeffrey A.; Jen,Anna. Growth factor modified protein matrices for tissue engineering. USP2007077247609.
  50. Harris Robert B. ; Sobel Michael. Heparin-binding peptides. USP1999035877153.
  51. Foster Donald C. (Seattle WA). Hybrid plasminogen activator. USP1996045504001.
  52. Weissleder Ralph (Charlestown MA) Bogdanov Alexei (Newton MA). Hydrogel compositions and methods of use. USP1996055514379.
  53. Sawhney, Amarpreet S.. In situ polymerizable hydrogels. USP2004116818018.
  54. Rhee Woonza M. ; Berg Richard A. ; Chu George H. ; DeLustro Frank A. ; Jolivette Dan M. ; McCullough Kimberly A.. Injectable or implantable biomaterials for filling or blocking lumens and voids of the body. USP1998055752974.
  55. Harris J. Milton (Huntsville AL). Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for m. USP1995085446090.
  56. Drumheller Paul D.. Materials and methods for the immobilization of bioactive species onto polymeric substrates. USP1999045897955.
  57. Tunkel Lev (Edison NJ) Krasovitski Boris (Nesher ILX). Method for energy separation and utilization in a vortex tube which operates with pressure not exceeding atmospheric pre. USP1996105561982.
  58. Burgess, Willson H.; Greisler, Howard P.; Drohan, William N.; Maciag, Thomas; MacPhee, Martin J.. Method of preparing a tissue sealant-treated biomedical material. USP2003056559119.
  59. Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Tefft Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA). Method of preparing crosslinked biomaterial compositions for use in tissue augmentation. USP1996085550187.
  60. Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Tefft Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA). Method of preparing crosslinked biomaterial compositions for use in tissue augmentation. USP1996065527856.
  61. Deschler Ulrich (Hanau DEX) Michel Rudolf (Freigericht DEX) Kleinschmit Peter (Hanau DEX) Wolff Siegfried (Bornheim-Merten DEX). Method of preparing sulfenic acid chlorides and sulfenic acid esters. USP1989054835297.
  62. Rhee Woonza M. ; DeLustro Frank A. ; Berg Richard A.. Method of using crosslinked polymer compositions in tissue treatment applications. USP2000126166130.
  63. Grinstaff Mark W. (Pasadena CA) Soon-Shiong Patrick (Los Angeles CA) Wong Michael (Champaign IL) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Desai Neil P. (Los Angeles CA). Methods for the preparation of blood substitutes for in vivo delivery. USP1997065635207.
  64. Sehl, Louis C.; Trollsas, Olof Mikael; Wallace, Donald G.; Toman, David; DeLustro, Frank A.; Schroeder, Jacqueline A.; Chu, George H.. Methods for tissue repair using adhesive materials. USP2004126833408.
  65. Ribi Hans O. (San Mateo CA) Guion Todd A. (Burlingame CA) Murdoch Joseph R. (Burlingame CA) Scott John C. (Los Gatos CA) Pan Victor (Burlingame CA) Choate Glenda L. (Belmont CA). Multi-optical detection system. USP1995065427915.
  66. Ribi Hans O. (San Mateo CA) Guion Todd A. (Burlingame CA) Murdoch Joseph R. (Burlingame CA) Scott John C. (Los Gatos CA) Pan Victor (Burlingame CA) Choate Glenda L. (Belmont CA). Multi-optical detection system. USP1993125268305.
  67. Harris J. Milton ; Veronese Francesco Maria,ITX ; Caliceti Paolo,ITX ; Schiavon Oddone,ITX. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces. USP1999085932462.
  68. Lee, Kang Choon; Park, Myung-Ok. Nasal transmucosal delivery of peptide conjugated with biocompatible polymers. USP2003016506730.
  69. Tregear ; Geoffrey William. Parathyroid hormone. USP1978044086196.
  70. Hock Janet M. (Indianapolis IN). Parathyroid hormone and raloxifene for increasing bone mass. USP1996045510370.
  71. Mueller Richard A. (Glencoe IL) Partis Richard A. (Evanston IL) Deason James R. (Wilmette IL). Phenolic thioethers as inhibitors of 5-lipoxygenase. USP1987124711903.
  72. Buchecker Richard,CHX ; Marck Guy,FRX ; Seiberle Hubert,DEX. Photocrosslinkable silane derivatives. USP2001086277502.
  73. Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX). Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers. USP1997055626863.
  74. Domschke, Angelika Maria; Francis, Vimala Mary. Porous hydrogels. USP2003116653420.
  75. Larm Olle (Nyngsvgen 86 S-161 39 Bromma SEX). Process for covalent coupling for the production of conjugates, and polysaccharide containing products thereby obtained. USP1986094613665.
  76. Larm Olle (Nyngsvgen 86 S-161 39 Bromma SEX). Process for covalent coupling for the production of conjugates, and products hereby obtained. USP1989034810784.
  77. Kopetzki Erhard,DEX. Process for the production of peptides by way of streptavidin fusion proteins. USP2000106136564.
  78. Cappello Joseph. Products comprising substrates capable of enzymatic cross-linking. USP1998065773577.
  79. Treco Douglas A. (Arlington MA) Heartlein Michael W. (Boxborough MA) Selden Richard F. (Wellesley MA). Protein production and protein delivery. USP1997065641670.
  80. Wallace Donald G. ; Cruise Gregory M. ; Rhee Woonza M. ; Schroeder Jacqueline Anne ; Coker ; III George T. ; Maroney Marcee M.. Rapid gelling biocompatible polymer composition. USP2001116312725.
  81. Wallace, Donald G.; Cruise, Gregory M.; Rhee, Woonza M.; Schroeder, Jacqueline Anne; Coker, III, George T.; Maroney, Marcee M.; Trollsas, Olof Mikael. Rapid-gelling biocompatible polymer composition and associated methods of preparation and use. USP2003096624245.
  82. Kronenberg Henry M. (Belmont MA) Nussbaum Samuel R. (Weston MA) Doi Tomoko (Osaka JPX). Recombinant DNA method for production of parathyroid hormone. USP1992125171670.
  83. Clark Richard A. ; Greiling Doris,GBX ; Gailit James. Recombinant fibronectin-based extracellular matrix for wound healing. USP1999095958874.
  84. MacPhee Martin James ; Drohan William Nash ; Liau Gene ; Haudenschild Christian. Supplemented and unsupplemented tissue sealants, method of their production and use. USP2000096117425.
  85. MacPhee Martin James ; Drohan William Nash ; Lasa ; Jr. Carlos I.,PHX ; Liau Gene ; Haudenschild Christian. Supplemented and unsupplemented tissue sealants, methods of their production and use. USP2001036197325.
  86. MacPhee Martin James ; Drohan William Nash ; Woolverton Christoper J.. Supplemented and unsupplemented tissue sealants, methods of their production and use. USP2000046054122.
  87. Hubbell Jeffrey A. (Austin TX) Massia Stephen P. (Austin TX) Desai Neil P. (Austin TX). Surfaces having desirable cell adhesive effects. USP1994075330911.
  88. Iguchi Yuichiro (Otsu JPX) Kimura Michio (Otsu JPX) Oka Koichiro (Ibaraki JPX). Thiol Methacrylate or acrylate resin and a method of making same. USP1997035612390.
  89. Iguchi Yuichiro (Otsu JPX) Kimura Michio (Otsu JPX) Oka Koichiro (Ibaraki JPX). Thiol methacrylate or acrylate resin. USP1994035294690.
  90. Labroo Virender (Mill Creek WA) Busby Sharon J. (Seattle WA). Transglutaminase cross-linkable polypeptides and methods relating thereto. USP1995065428014.
  91. Ostlie Brian W.. Visible light polymerizable thiol-ene composition. USP1999035876805.

IPC 상위 출원인