[특허]Drug-delivery pumps with dynamic, adaptive control

Drug-delivery pumps with dynamic, adaptive control 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61M-005/168 A61M-005/142 A61M-005/172 A61F-009/00 G06F-019/00 A61M-005/148 A61M-031/00
출원번호	US-0858808 (2010-08-18)
등록번호	US-9199035 (2015-12-01)
발명자 / 주소	Shih, Jason Brennan, Jeffrey Jiang, Fukang Caffey, Sean
출원인 / 주소	MiniPumps, LLC.
대리인 / 주소	Morgan, Lewis & Bockius LLP
인용정보	피인용 횟수 : 0 인용 특허 : 144

초록

In various embodiments, actuation of a drug-delivery pump is controlled based on a change in a condition of the pump.

대표청구항 ▼

1. A drug-delivery pump operating at period time intervals, comprising: a drug reservoir configured to hold a liquid drug;a cannula for conducting the liquid drug from the reservoir to a target site;a pump actuator comprising electrolysis electrodes driven by a current for forcing the liquid drug from the reservoir through the cannula;at least one physical sensor for measuring at least one quantitative electrical or flow pump operating parameter;a memory for storing (i) a fixed dosage of the liquid drug to be delivered by the pump actuator through the cannula during each of a plurality of dosing intervals and (ii) a value of the at least one quantitative pump operating parameter measured by the at least one physical sensor obtained during a previous at least one dosing intervals interval, the pump actuator being operative during the previous dosing interval to deliver the fixed dosage; andcircuitry for controlling the current supplied to the pump actuator by computing actuator settings based at least in part on the stored fixed dosage and a change in a condition of the pump actuator specified by a quantitative difference between the stored value of the pump operating parameter and a current value of the pump operating parameter, and adjusting the pump actuator in accordance with the computed actuator settings to thereby compensate for the change in a maximum flow rate reached while the current is supplied to the actuator pump in the current dosing interval or an amount of liquid delivered due to residual pressure after the current is no longer supplied to the actuator pump in the current dosing interval. 2. The pump of claim 1, wherein the circuitry maintains delivery of the fixed dosage of the liquid drug at periodic time intervals to the target site. 3. The pump of claim 1 further comprising a flow sensor for measuring a flow rate of the liquid drug through the cannula. 4. The pump of claim 3, wherein the circuitry controls the pump actuator based, at least in part, on an analysis of the flow rate. 5. The pump of claim 4, wherein the circuitry further controls the pump actuator based on real-time data from the pump actuator. 6. The pump of claim 1, wherein the pump actuator further comprises: an electrolyte chamber;an expandable diaphragm separating the chamber and the drug reservoir and providing a fluid barrier therebetween; andthe electrolysis electrodes for causing evolution of a gas in the electrolyte chamber to thereby expand the expandable diaphragm so that the liquid drug is forced from the drug reservoir into the cannula. 7. The pump of claim 6, wherein diaphragm expansion is adjusted by varying actuation current supplied to the electrolysis electrodes. 8. The pump of claim 6, wherein diaphragm expansion is adjusted by varying an actuation duration of the electrodes. 9. The pump of claim 6, wherein the electrolysis electrodes are driven with a constant current. 10. The pump of claim 6, wherein the electrolysis electrodes are driven with a time-varying current waveform. 11. The pump of claim 1, wherein the circuitry is configured to store values of the at least one pump operating parameter in the memory at each of the plurality of dosing intervals. 12. The pump of claim 1, wherein each of the at least one pump operating parameter is a flow-related parameter selected from the group consisting of (i) the current flowing through the electrolysis electrode of the actuator pump, (ii) a maximum flow rate of the liquid drug through the cannula, (iii) a variation in flow patterns of the liquid drug through the cannula, (iv) an actuation time required for the pump to achieve a particular flow rate of the liquid drug through the cannula, (v) a time required for a flow of the liquid drug to ramp down from a particular flow rate to a flow rate of zero, (vi) a time delay between an initial actuation of the pump actuator and an initial flow of liquid drug through the cannula, (vii) an efficiency of the pump actuator, (viii) an internal pressure of the drug reservoir, (ix) an acceleration experienced by the pump actuator, (x) a resistance of a flow sensor, and (xi) at least one physical dimension of the pump actuator, the drug reservoir, or the cannula. 13. The drug-delivery pump of claim 12, wherein the efficiency of the pump actuator is determined based at least in part on an amount of charge pumped through the pump actuator and an amount of gas generated by the electrolysis electrodes. 14. The drug-delivery pump of claim 1, wherein the at least one quantitative electrical or flow pump operating parameter is obtained by direct measurement. 15. The drug-delivery pump of claim 1, wherein the circuitry is configured to control the pump actuator to maintain a target dosage level. 16. The drug-delivery pump of claim 1, wherein the circuitry adjusts the pump actuator to continue delivering the fixed dosage during the current dosing interval. 17. The drug-delivery pump of claim 1, wherein the computed actuator settings comprises an actuation time required for the pump actuator to achieve a particular flow rate of the liquid drug through the cannula, and a flow profile of the pump actuator resulting from activation of the pump actuator in accordance with the computed actuator settings comprises a time required for a flow of the drug to ramp down from a particular flow rate to a flow rate of zero. 18. A drug-delivery pump comprising: a drug reservoir configured to hold a liquid drug;a cannula for conducting the liquid drug from the reservoir to a target site;a pump actuator comprising electrolysis electrodes driven by a current for forcing the liquid from the reservoir through the cannula during a plurality of dosing cycles;at least one physical sensor for measuring at least one quantitative electrical or flow pump operating parameter;a memory for storing (i) a fixed dosage to be delivered by the pump actuator through the cannula during each of a plurality of different dosing cycles and (ii) values of the at least one quantitative electrical or flow pump operating parameter measured by the at least one physical sensor obtained during each of the plurality of different dosing cycles, the pump actuator being operative during each of the plurality of different dosing cycles to deliver the fixed dosage; andcircuitry for adaptively controlling the current supplied to the pump actuator by computing actuator settings for a new dosing cycle based at least in part on the stored fixed dosage and a change in the values between the plurality of different dosing cycles stored in the memory, and adjusting the pump actuator in accordance with the computed actuator settings to thereby compensate for a change in a maximum flow rate reached while the current is supplied to the actuator pump or an amount of liquid delivered due to residual pressure after the current is no longer supplied to the actuator pump.

이 특허에 인용된 특허 (144)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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Drug-delivery pumps with dynamic, adaptive control 원문보기

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연합인증

Drug-delivery pumps with dynamic, adaptive control 원문보기

초록

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연구과제 타임라인

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