Disclosed in an embodiment herein is a well plate system including a well plate device, including three plates disposed above one another. The two top plates include wells disposed therein which are in fluid communication with one another, and which when the device is in a resting position, the seco
Disclosed in an embodiment herein is a well plate system including a well plate device, including three plates disposed above one another. The two top plates include wells disposed therein which are in fluid communication with one another, and which when the device is in a resting position, the second plate rests on top of the third plate to create a fluid sealed well. The third plate includes fluid drainage openings, such that when the system is in an activated position, the plates are moved such that the fluid within the wells exits through these openings. The system can be fully automated, and can include one or more motors to control movement of the plates. The system can also operate manually with a hinge connected to the plates.
대표청구항▼
1. A well plate system, comprising: a well plate device, comprising; a first plate, comprising one or more wells, each of said one or more wells comprising a well wall and a fluid permeable bottom surface;a second plate disposed beneath the first plate, said second plate comprising a top side, a bot
1. A well plate system, comprising: a well plate device, comprising; a first plate, comprising one or more wells, each of said one or more wells comprising a well wall and a fluid permeable bottom surface;a second plate disposed beneath the first plate, said second plate comprising a top side, a bottom side, and an outer edge around the perimeter of the plate, the plate comprising a fluid containment border around at least a portion of the outer edge, said second plate comprising one or more wells, each of said one or more wells comprising a well wall;a third plate disposed beneath the second plate, said third plate comprising a top side, a bottom side, an outer edge around the perimeter of the plate, a fluid containment border around at least a portion of the outer edge, wherein when said first plate, said second plate and said third plate are associated together in a resting position, at least one well of the second plate is aligned with at least one well of the first plate thereby providing a fluid communication there between, and said second plate abuts against the top side of the third plate to form at least one fluid sealed well. 2. The system of claim 1, wherein the third plate comprises at least one drainage opening extending there through, such that when the system is in a resting position, fluid is contained within the fluid sealed well, and when the second and third plates are dissociated to form an activated position, fluid flows through the at least one drainage opening in the third plate. 3. The system of claim 2, wherein a drainage container is disposed below the third plate. 4. The system of claim 1, wherein said first, second and third plates are mechanically and/or electrically connected to one another. 5. The system of claim 4, wherein said mechanical connection includes a hinging arm. 6. The system of claim 1, wherein at least a first motor, a processor, and a controller are in electrical communication with the first plate, the second plate, and/or the third plate to provide automated movement of the plates. 7. The system of claim 6, wherein a second motor is in electrical communication with the first and/or second plates to provide horizontal movement of the first and/or second plate(s) to provide a mechanical agitation of the plate(s). 8. The system of claim 6, wherein a third motor is in electrical communication with the first plate, the second plate, and/or the third plate to provide automated movement of the plate(s) independently of the movement provided by the first motor. 9. The system of claim 1, wherein one of either the first and second plates or the third plate is vertically adjusted relative to the other of the first and second plates and the third plate. 10. The system of claim 1, wherein one of either the first and second plates or the third plate is horizontally adjusted relative to the other of the first and second plates and the third plate. 11. The system of claim 10, wherein the plates are horizontally moved such that the at least one drainage opening in the third plate is aligned with the one or more wells of the first and second plates, forming a fluid connection there between. 12. The system of claim 1, wherein both of the first and second plates and the third plate are moved vertically in opposite directions to create a gap between the second plate and the third plate. 13. The system of claim 1, wherein both of the first and second plates and the third plate are moved horizontally in opposing directions. 14. The system of claim 13, wherein the plates are horizontally moved such that the at least one drainage opening in the third plate is aligned with the one or more wells of the first and second plates, forming a fluid connection there between. 15. The system of claim 1, wherein a sealing material surrounds the portion of the cylindrical wall of the one or more wells of the second plate adjacent to the third plate, such that when the one or more wells of the second plate contact the third plate, a seal is created there between. 16. The system of claim 1, wherein at least a portion of the bottom surface of the one or more wells comprises a fluid permeable material. 17. The system of claim 1, wherein at least a portion of the bottom surface of the one or more wells of the first plate comprises a mesh material. 18. The system of claim 1, wherein at least a portion of the bottom surface of the one or more wells of the first plate comprises a solid surface with at least one opening there through, providing a fluid communication between the first and second plates. 19. The system of claim 1, wherein a pump and a delivery conduit are connected between the first and/or second plate and a delivery container, wherein the delivery container is configured to house a fluid to be pumped into the one or more wells of the first and/or second plate via the pump and the delivery conduit. 20. The system of claim 19, wherein a draining conduit is associated with the first or second plate, such that any excess fluid in or on the first and/or second plate(s) is collected by the draining conduit. 21. The system of claim 20, wherein the draining conduit connects between the first and/or second plate and the drainage container. 22. The system of claim 1, wherein the third plate comprises raised members on its top side, wherein at least one of said raised members are aligned with at least one well of the first and second plates, providing fluid communication there between. 23. A method of tissue processing using a well plate system comprising a well plate device, comprising a first plate, comprising one or more wells, each of said one or more wells comprising a well wall and a fluid permeable bottom surface, a second plate disposed beneath the first plate, said second plate comprising a top side, a bottom side, and an outer edge around the perimeter of the plate, the plate comprising a fluid containment border around at least a portion of the outer edge, said second plate comprising one or more wells, each of said one or more wells comprising a well wall, a third plate disposed beneath the second plate, said third plate comprising a top side, a bottom side, an outer edge around the perimeter of the plate, a fluid containment border around at least a portion of the outer edge, wherein when said first plate, said second plate and said third plate are associated together in a resting position, at least one well of the second plate is aligned with at least one well of the first plate thereby providing a fluid communication there between, and said second plate abuts against the top side of the third plate to form at least one fluid sealed well the method comprising: providing a first plate vertically disposed above a second plate, wherein the first plate comprises one or more wells, said wells configured to receive a sample;providing a fluid delivery system coupled to the well plate system, said fluid delivery system comprising a pump and a fluid conduit to deliver a first fluid to one or more wells of the second plate, wherein once the one or more wells of the second plate are at least partially filled with the first fluid, any excess of the first fluid is removed from the second plate by at least one drain conduit;vertically lowering with a first motor the first plate onto the second plate, wherein the one or more wells of the first and second plates are vertically aligned, such that the first fluid from the one or more wells of the second plate passes through the one or more wells of the first plate and contacts the sample;vertically raising the first plate with the first motor, wherein the first fluid drains from the one or more wells of the first plate into the one or more wells of the second plate; andvertically raising the second plate with the first motor such that a seal between the second and the third plate is broken wherein the first fluid drains from the second plate onto the third plate and through at least one drainage opening in the third plate. 24. The method of claim 23, further comprising vertically lowering the second plate with the first motor onto the third plate creating a seal between the one or more wells of the second plate and the third plate, activating the fluid delivery system to initiate the pump to deliver a second fluid into the second plate via the conduit, wherein the second fluid is delivered to the one or more wells of the second plate. 25. The method of claim 23, further comprising horizontally moving the plate by the second motor to provide a mechanical agitation of the plate. 26. A well plate system, comprising: a well plate device; a first plate comprising a top surface, a bottom surface and an outer edge surface, said first plate having openings extending from the top surface to the bottom surface, wherein each of said openings are configured to receive a well comprising a wall and a bottom surface;a second plate comprising a top surface, a bottom surface and an outer edge surface around the perimeter of the plate, said second plate comprising a fluid containment border around said outer edge surface, said second plate having openings extending from the top surface to the bottom surface, said openings configured to receive a well, said well comprising a wall, wherein the openings of the first plate and the openings of the second plate are vertically aligned and at least one opening of the second plate is configured to receive a well of the first plate;a third plate comprising a top surface, a bottom surface, and an outer edge surface around the perimeter of the plate, said third plate having drainage openings extending from the top surface to the bottom surface, and a border surrounding at least a portion of the outer edge; anda first motor electrically connected to at least one of the first, second and third plates to provide movement of at least one of the plates relative to at least another of the plates, wherein the first motor is configured to move at least the first plate relative to the second plate.
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