[특허]Method for treatment of castration-resistant prostate cancer

Method for treatment of castration-resistant prostate cancer 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12N-015/11 C07H-021/04 C07H-021/02 A61K-031/713 A61K-045/06 A61K-031/4166 A61K-031/712
출원번호	US-0560673 (2014-12-04)
등록번호	US-9205102 (2015-12-08)
발명자 / 주소	Gleave, Martin E. Ischia, Joseph
출원인 / 주소	The University of British Columbia
대리인 / 주소	Larson & Anderson, LLC
인용정보	피인용 횟수 : 0 인용 특허 : 176

초록 ▼

Castrate resistant prostate cancer cell lines exhibiting resistance to the androgen-receptor antagonist enzaluatamide overexpress one or both of IGFBP-2 or IGFBP-5 when compared to non-resistant cell lines. Oligonucleotides that target IGFBP-2 and IGFBP-5 can be used to overcome this resistance or a

대표청구항 ▼

1. A method for treatment of a patient having a cancer exhibiting resistance to an androgen-receptor antagonist comprising administering to the patient an amount of a sequence-related oligonucleotide therapeutic agent that reduces expression of IGFBP-2 and IGFBP-5. 2. The method of claim 1 wherein the androgen-receptor antagonist impairs nuclear translocation of androgen-receptor. 3. The method of claim 1, wherein the androgen-receptor antagonist is a diarylthiohydantoin. 4. The method of claim 3, wherein the androgen-receptor antagonist is enzalutamide. 5. The method of claim 4, wherein the agent that reduces expression of IGFBP-2 and IGFBP-5 is a bispecific antisense oligonucleotide. 6. The method of claim 5, wherein the agent has the sequence of SEQ ID NO.: 1. 7. The method of claim 5, wherein the agent is OGX-225 (SEQ ID NO. 2). 8. The method of claim 4, wherein the agent that reduces expression of IGFBP-2 and IGFBP-5 is an siRNA. 9. The method of claim 8, wherein the siRNA is an RNA duplex of two complementary RNA strands in which one of the strands has the sequence of SEQ ID NO.: 10. 10. The method of claim 1, wherein the agent that reduces expression of IGFBP-2 and IGFBP-5 is a bispecific antisense oligonucleotide. 11. The method of claim 10, wherein the agent has the sequence of SEQ ID NO.: 1. 12. The method of claim 10, wherein the agent is OGX-225 (SEQ ID NO. 2). 13. The method of claim 1, wherein the agent that reduces expression of IGFBP-2 and IGFBP-5 is an siRNA. 14. The method of claim 13, wherein the siRNA is an RNA duplex of two complementary RNA strands in which one of the strands has the sequence of SEQ ID NO.: 10. 15. The method of claim 1, wherein the cancer exhibits a reduced response to the androgen-receptor antagonist. 16. A method for treatment of a patient having prostate cancer comprising concurrently administering to the patient (a) a first therapeutic agent that is an androgen-receptor antagonist that binds to the ligand binding domain of an androgen-receptor; and(b) a second therapeutic agent that is a sequence-related oligonucleotide therapeutic agent that reduces expression of IGFBP-2 and IGFBP-5, wherein the prostate cancer is castrate-resistant prostate cancer. 17. The method of claim 16, wherein the prostate cancer is a metastatic castrate-resistant prostate cancer. 18. The method of claim 16, wherein the first therapeutic agent is an androgen-receptor antagonist that impairs nuclear translocation of an androgen-receptor. 19. The method of claim 18, wherein the androgen-receptor antagonist is a diarylthiohydantoin. 20. The method of claim 16, wherein the agent that reduces expression of IGFBP-2 and IGFBP-5 is a bispecific antisense oligonucleotide. 21. The method of claim 16, wherein the agent that reduces expression of IGFBP-2 and IGFBP-5 is an siRNA. 22. The method of claim 21, wherein the siRNA is an RNA duplex of two complementary RNA strands in which one of the strands has the sequence of SEQ ID NO.: 10. 23. The method of claim 20, wherein the bispecific antisense oligonucleotide is SEQ ID NO.: 1 or OGX-225 (SEQ ID NO. 2). 24. The method of claim 19, wherein the androgen-receptor antagonist is a enzalutamide.

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A	생활필수품
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A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Method for treatment of castration-resistant prostate cancer 원문보기

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구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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Method for treatment of castration-resistant prostate cancer 원문보기

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