최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0107053 (2013-12-16) |
등록번호 | US-9216205 (2015-12-22) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 4 인용 특허 : 394 |
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
1. An mRNA encoding SEQ ID NO: 6373, wherein said mRNA comprises a coding region, said coding region having greater than 80% identity to SEQ ID NO: 32794. 2. The mRNA of claim 1, wherein the mRNA comprises at least one untranslated region 5′ relative to the coding region and at least one untranslate
1. An mRNA encoding SEQ ID NO: 6373, wherein said mRNA comprises a coding region, said coding region having greater than 80% identity to SEQ ID NO: 32794. 2. The mRNA of claim 1, wherein the mRNA comprises at least one untranslated region 5′ relative to the coding region and at least one untranslated region 3′ relative to the coding region. 3. The mRNA of claim 2, wherein the 5′ untranslated region is heterologous to the coding region of the mRNA. 4. The mRNA of claim 2, wherein the 3′ untranslated region is heterologous to the coding region of the mRNA. 5. The mRNA of claim 2, wherein the 5′ untranslated region and the 3′ untranslated region are heterologous to the coding region of the mRNA. 6. The nucleic acid of claim 2, wherein the mRNA comprises at least two stop codons. 7. A pharmaceutical composition comprising the mRNA of claim 1 and a pharmaceutically acceptable excipient. 8. The pharmaceutical composition of claim 7 wherein the pharmaceutically acceptable excipient is selected from a solvent, aqueous solvent, non-aqueous solvent, dispersion media, diluent, dispersion, suspension aid, surface active agent, isotonic agent, thickening or emulsifying agent, preservative, lipid, lipidoids liposome, lipid nanoparticle, core-shell nanoparticles, polymer, lipoplex, peptide, protein, cell, hyaluronidase, and mixtures thereof. 9. The mRNA of claim 1, wherein the coding region is selected from the group consisting of SEQ ID NO: 32794, 32800 and 32826. 10. A method of producing a protein of interest in a cell, tissue or organism comprising contacting said cell, tissue or organism with the mRNA of claim 8. 11. The method of claim 10, wherein the mRNA comprises at least one untranslated region 5′ relative to the coding region and at least one untranslated region 3′ relative to the coding region. 12. The method of claim 11, wherein the 5′ untranslated region is heterologous to the coding region of the mRNA. 13. The method of claim 11, wherein the 3′ untranslated region is heterologous to the coding region of the mRNA. 14. The method of claim 11, wherein the 5′ untranslated region and the 3′ untranslated region are heterologous to the coding region of the mRNA. 15. The method of claim 11, wherein the mRNA comprises at least two stop codons.
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