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Plant cell culture expressing human lysosomal proteins and uses thereof

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-036/23
  • C12N-009/24
  • C12N-009/42
  • C12N-009/40
  • C12N-015/82
  • C12P-021/00
출원번호 US-0292966 (2014-06-02)
등록번호 US-9220737 (2015-12-29)
우선권정보 IL-155588 (2003-04-27)
발명자 / 주소
  • Shaaltiel, Yoseph
  • Baum, Gideon
  • Bartfeld, Daniel
  • Hashmueli, Sharon
  • Lewkowicz, Ayala
출원인 / 주소
  • Protalix Ltd.
인용정보 피인용 횟수 : 0  인용 특허 : 48

초록

A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or by-passing the Golgi. The invention further relates to vectors and methods for expression and production

대표청구항

1. A method of increasing hydrolysis of glycosphingolipid glucocerebroside in macrophages of a subject in need thereof, the method comprising administering to said subject a therapeutically effective amount of lyophilized plant cells expressing a recombinant human glucocerebrosidase protein comprisi

이 특허에 인용된 특허 (48)

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  24. Shaaltiel, Yoseph; Baum, Gideon; Bartfeld, Daniel; Hashmueli, Sharon; Lewkowicz, Ayala, Human lysosomal proteins from plant cell culture.
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  40. Erwin, Robert L.; Grill, Laurence K.; Pogue, Gregory P.; Turpen, Thomas H.; Kumagai, Monto H., Production of lysosomal enzymes in plants by transient expression.
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  45. Keisuke Fujita JP, Tableted product prepared by vacuum freeze-drying of a plant belonging to genus aloe of family Liliaceae and the method for producing same.
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  47. Galili Gad (Rehovot ILX) Shaul Orit (Petah Tivka ILX) Perl Avihai (Rishon-le-Zion ILX), Transgenic plants overproducing threonine and lysine.
  48. Shemesh, Ronen; Bernstein, Jeanne; Dahary, Dvir; Shalev, Gil; Baum, Gideon; Shaaltiel, Yoseph, Variants of human glycoprotein hormone alpha chain: compositions and uses thereof.
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