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Cell therapy method for the treatment of tumors

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-005/071
  • C12N-005/0783
  • A61K-048/00
  • A61K-038/20
  • A61K-038/21
  • A61K-039/00
  • A61K-041/00
  • C12N-005/07
  • A61K-035/12
출원번호 US-0782264 (2007-07-24)
등록번호 US-9222070 (2015-12-29)
발명자 / 주소
  • Leturcq, Didier J.
  • Moriarty, Ann M.
  • Jackson, Michael R.
  • Peterson, Per A.
  • Richards, Jon M.
출원인 / 주소
  • Janssen Pharmaceuticals, Inc.
대리인 / 주소
    McCormack, Myra H.
인용정보 피인용 횟수 : 0  인용 특허 : 28

초록

T cell responses are often diminished in humans with a compromised immune system. We have developed a method to isolate, stimulate and expand naïve cytotoxic T lymphocyte precursors (CTLp) to antigen-specific effectors, capable of lysing tumor cells in vivo. This ex vivo protocol produces fully func

대표청구항

1. A method for producing activated CD8+ T cells specific to one or more melanoma antigens for administration to a subject, comprising: a. harvesting CD8+ T cells and CD8-depeleted mononuclear cells from the subject;b. culturing said CD8+ T cells with a non-naturally occurring antigen-presenting cel

이 특허에 인용된 특허 (28)

  1. Stabinsky Yitzhak (Boulder CO), Consensus human leukocyte interferon.
  2. Stabinsky Yitzhak (Boulder CO), Consensus human leukocyte interferon.
  3. Gillis Steven (Woodinville WA), Constitutive production of interleukin 2 by a T cell hybridoma.
  4. Gillis Steven (Woodinville WA), Constitutive production of interleukin 2 by a T cell hybridoma.
  5. Peterson Per A. (LaJolla CA) Jackson Michael (Del Mar CA) Langlade-Demoyen Pierre (Del Mar CA), Drosophila cell lines expressing genes encoding MHC class I antigens and B2-microglobulin and capable of assembling empt.
  6. Stern Lawrence J. (Arlington MA), Empty major histocompatibility class II heterodimers.
  7. Cullen Bryan R. (West Caldwell NJ), Enhanced expression of human interleukin-2 in mammalian cells.
  8. Cheever Martin A. ; Disis Mary L., Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is associated.
  9. Peterson Per A. ; Jackson Michael ; Langlade-Demoyen Pierre, In vitro activation of cytotoxic T cells.
  10. Peterson Per A. (La Jolla CA) Jackson Michael (Del Mar CA) Langlade-Demoyen Pierre (Del Mar CA), In vitro activation of cytotoxic t-cells using insect cells expressing human class I MHC and b 상세보기
  • Kubo Ralph T. (San Diego CA) Grey Howard M. (La Jolla CA) Sette Alessandro (La Jolla CA) Celis Esteban (San Diego CA), Induction of anti-tumor cytotoxic T lymphocytes in humans using synthetic peptide epitopes.
  • Dranoff Glenn (Lexington MA) Mulligan Richard C. (Lincoln MA) Pardoll Drew (Baltimore MD), Irradiated tumor cell vaccine engineered to express GM-CSF.
  • Lurquin Christophe (Brussels BEX) Boon-Falleur Thierry (Brussels BEX), Isolated nucleic acid molecules which are members of the MAGE-Xp family and uses thereof.
  • Townsend Alan (Headington GB2) Bastin Judy (Headington GB2) Boon-Falleur Thierry (Brussels BEX) van der Bruggen Pierre (Brussels BEX) Coulie Pierre (Brussels BEX), Isolated, MAGE-3 derived peptides which complex with HLA-A2 molecules and uses thereof.
  • Susan R. Webb ; Ola Winqvist SE; Lars Karlsson ; Michael R. Jackson ; Per A. Peterson, MHC class II antigen-presenting systems and methods for activating CD4+ T cells.
  • Kawakami Yutaka ; Rosenberg Steven A., Melanoma antigens and their use in diagnostic and therapeutic methods.
  • Kawakami Yutaka ; Rosenberg Steven A., Melanoma antigens and their use in diagnostic and therapeutic methods.
  • Kawakami Yutaka ; Rosenberg Steven A., Melanoma antigens and their use in diagnostic and therapeutic methods.
  • Boon-Falleur Thierry (Brussels BEX) Brichard Vincent (Brussels BEX) Van Pel Aline (Brussels BEX) De Plaen Etienne (Brussels BEX) Coulie Pierre (Brussels BEX) Renauld Jean-Christope (Brussels BEX) Wlf, Method for detecting complexes containing human leukocyte antigen A2 (HLA-A2) molecules and a tyrosinase drived peptide.
  • De Boer Mark (Almere CA NLX) Conroy Leah B. (Pacifica CA), Method for generation of antibodies to cell surface molecules.
  • Lurquin Christophe,BEX ; Brasseur Francis,BEX ; Boon-Falleur Thierry,BEX, Method of screening for cancer by detecting messenger RNA for a MAGE-XP gene.
  • Sahin Ugur,DEX ; Tureci Ozlem,DEX ; Chen Yao-Tseng ; Old Lloyd J. ; Pfreundschuh Michael,DEX, Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith.
  • Robbins Paul F. ; Rosenberg Steven A., P15 and tyrosinase melanoma antigens and their use in diagnostic and therapeutic methods.
  • Jameson Bradford A. (Philadelphia PA) Choksi Swati (Broomall PA) Korngold Robert (Cherry Hill NJ), Peptides that inhibit T cell activation and methods of using the same.
  • Gillis Steven (Woodinville WA), Process for preparing human interleukin 2.
  • Kappler John W. ; Marrack Philippa, Product and process for T cell regulation.
  • Riddell Stanley R. ; Greenberg Philip D., Rapid expansion method ("REM") for in vitro propagation of T lymphocytes.
  • Weissmann Charles (Zurich CHX), Recombinant DNA molecules and their use in producing human interferon-like polypeptides.
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