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pH dependent carriers for targeted release of pharmaceuticals along the gastrointestinal tract, compositions therefrom, and making and using same

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/192
  • A61K-031/196
  • A61K-031/405
  • A61K-031/60
  • A61K-031/616
  • A61K-045/06
  • A61K-047/12
  • A61K-047/14
  • A61K-047/24
  • A61K-009/00
  • A61K-009/48
출원번호 US-0791189 (2013-03-08)
등록번호 US-9226892 (2016-01-05)
발명자 / 주소
  • Marathi, Upendra K.
  • Childress, Susann Edler
  • Gammill, Shaun L.
  • Strozier, Robert W.
출원인 / 주소
  • PLX PHARMA INC.
대리인 / 주소
    Foley & Lardner LLP
인용정보 피인용 횟수 : 1  인용 특허 : 43

초록

Novel drug carriers capable of targeted and/or pH dependent release of biologically active agents into selected pH environments including the gastrointestinal (GI), ophthalmic, urinary, or reproductive tracts. Unexpectedly, carriers including free fatty acids (FFA) are able to deliver biologically a

대표청구항

1. A method of targeting release of a non-steroidal anti-inflammatory drug (NSAID) to the small intestine of a subject, comprising: orally administering to the subject an ingestible composition consisting of a non-aqueous solid-in-oil suspension of an effective amount of the solid NSAID in a carrier

이 특허에 인용된 특허 (43)

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  3. Horrobin David F. (Guildford GB2) Knowles Philip (Carlisle GB2), Fatty acid derivatives.
  4. Schulz Volker (Cologne DEX) Leyck Sigurd (Pulheim DEX) Drr Manfred (Pulheim-Dansweiler DEX) Ghyczy Miklos (Cologne DEX) Wendel Armin (Cologne DEX) Hager Jrg (Cologne DEX), Formulation with special 1,2-diacylglycero-3-phosphocholines for the treatment of gastrointestinal disorders.
  5. Ghyczy Miklos (Cologne DEX) Erds Adorjan (Cologne DEX) Heidemann Gnter (Geilenkirchen-Tripsrath DEX), Inflammation-preventing pharmaceutical composition of oral administration.
  6. Ghyczy Miklos (Cologne DEX) Erds Adorjan (Cologne DEX) Heidemann Gnter (Geilenkirchen-Tripsrath DEX) Ritzmann Gtz (Cologne DEX), Inflammation-preventing pharmaceutical composition of oral administration.
  7. Ghyczy Miklos (Cologne DEX) Erds Adorjan (Cologne DEX) Heidemann Gnter (Geilenkirchen-Tripsrath DEX) Ritzmann Gtz (Cologne DEX), Inflammation-preventing pharmaceutical composition of oral administration.
  8. Ghyczy, Miklos; Erdos, Adorjan; Heidemann, Gunter; Ritzmann, Gotz, Inflammation-preventing pharmaceutical composition of oral administration.
  9. Garrity Martha ; Varadarajan John ; Watson Alan David, Liposomal agents.
  10. Lucchetti Giovanni (Rome ITX) Assogna Guiseppe (Rome ITX) Bagnato Pietro (Latina ITX), Liposomal piroxicam formulations.
  11. Cao Zhisong ; Giovanella Beppino C., Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs.
  12. Park Moo W. (Darnestown MD) Caldwell Henry C. (Ambler PA), Liquid oral pharmaceutical compositions of non-steroidal anti-inflammatory drugs.
  13. Lichtenberger Lenard M. (Houston TX), Methods and compositions employing unique mixtures of polar and neutral lipids for protecting the gastrointestinal tract.
  14. Lichtenberger Lenard M. (Houston TX), Methods and compositions employing unique mixtures of polar and neutral lipids for protecting the gastrointestinal tract.
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  16. Lichtenberger Lenard M. (Houston TX 4), Methods and compositions employing unique mixtures of polar and neutral lipids for surfactant replacement therapy.
  17. Weiner, Alan L.; Cullis, Pieter R., Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs.
  18. Lichtenberger Lenard ; Butler Bruce D, Methods of enhancing the therapeutic activity of NSAIDS and compositions of zwitterionic phospholipids useful therein.
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  20. Yesair David W., Mixed Liped-Bicarbonate colloidal particles for delivering drugs or calories.
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  23. Geyer Robert P. (Brookline MA) Tuliani Vinod (Media PA), Non-aqueous microemulsions for drug delivery.
  24. Lin ; Song-Ling ; Pramoda ; Maturu K., Permanent suspension pharmaceutical dosage forms.
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  26. Horrobin David F. (Surrey GB2) Manku Mehar S. (Nova Scotia CAX) Huang Yung S. (Nova Scotia CAX), Pharmaceutical and dietary compositions.
  27. Barnwell Stephen George,GBX, Pharmaceutical composition containing a low detergent effect bile salt and an active compound that undergoes biliary ex.
  28. Cho Young W. (Chester NJ), Pharmaceutical compositions.
  29. Chen,Feng Jing; Venkateshwaran,Srinivasan; Krill,Steven L.; Patel,Mahesh V., Pharmaceutical formulations and systems for improved absorption and multistage release of active agents.
  30. Inagi Toshio (Tokorozawa JPX) Inoue Masayuki (Higashi-Murayama JPX) Muramatsu Toyojiro (Sayama JPX), Pharmaceutical preparation for endermic application.
  31. Popescu Mircea C. (Plainsboro NJ) Tremblay Paul A. (Hamilton NJ) Janoff Andrew S. (Yardley PA) Ostro Marc J. (Princeton NJ) Chan Elaine (Willow Grove PA) Weiner Alan (Lawrenceville NJ), Pharmacological agent-lipid solution preparation.
  32. Haynes Duncan H. (4051 Barbarossa Ave. Miami FL 33133), Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs.
  33. Bierdel-Willkommen Elvira,DEX ; Sambale Clemens,DEX ; Hahnlein Wolfgang,DEX, Soft gelatin capsules.
  34. Patel Mahesh V. ; Chen Feng-Jing, Solid carriers for improved delivery of active ingredients in pharmaceutical compositions.
  35. Patel, Mahesh V.; Chen, Feng-Jing, Solid carriers for improved delivery of active ingredients in pharmaceutical compositions.
  36. Patel, Mahesh V.; Chen, Feng-Jing, Solid carriers for improved delivery of hydrophobic active ingredients in pharmaceutical compositions.
  37. Martin Francis J. (San Francisco CA) Woodle Martin C. (Menlo Park CA) Redemann Carl (Walnut Creek CA) Yau-Young Annie (Palo Alto CA), Solid tumor treatment method and composition.
  38. Ghyczy Miklos (Cologne DEX) Ritzmann Gtz (Cologne DEX) Erds Adorjan (Cologne DEX) Etschenberg Eugen (Cologne DEX), Stable injectable solutions of indoleacetic acid derivatives.
  39. Liversidge Gary G. (West Chester PA) Conzentino ; Jr. Philip (West Chester PA) Cundy Kenneth C. (Pottstown PA) Sarpotdar Pramod P. (Malvern PA), Surface modified NSAID nanoparticles.
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  41. Dollerup Jens (Lyngby DKX), Use of non-steroidal antiiflammatory agents in macular degeneration.
  42. Forssen Eric ; Cox Gerry ; Hair Dennis, Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties.
  43. Fukushima Tsunekazu (Hyogo JPX) Emoto Hiroshi (Osaka JPX) Kagitani Yoshio (Nara JPX) Yokoyama Kazumasa (Osaka JPX) Nishida Masayuki (Osaka JPX) Suyama Tadakazu (Kyoto JPX), Water soluble drug complex and method for production of same.

이 특허를 인용한 특허 (1)

  1. Marathi, Upendra K.; Childress, Susann Edler; Gammill, Shaun L.; Strozier, Robert W., PH dependent carriers for targeted release of pharmaceuticals along the gastrointestinal tract, compositions therefrom, and making and using same.
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