[특허]System and method for tissue construction using an electric field applicator

Tokyo Electron Limited

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특허 상세정보

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System and method for tissue construction using an electric field applicator

특허상세정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-027/453 G01N-027/447 C23C-016/50 C12M-003/00 B03C-005/00 H01J-037/32 C12M-001/26 B03C-005/02 A61F-002/00 H01L-021/02 H01L-021/67 C23C-016/04 C23C-016/48
출원번호	US-0823701 (2012-07-31)
등록번호	US-9228261 (2016-01-05)
국제출원번호	PCT/US2012/049056 (2012-07-31)
§371/§102 date	20130314 (20130314)
국제공개번호	WO2013/019814 (2013-02-07)
발명자 / 주소	Brcka, Jozef
출원인 / 주소	Tokyo Electron Limited
대리인 / 주소	Wood, Herron & Evans, LLP
인용정보	피인용 횟수 : 0 인용 특허 : 4

초록
▼

A method and apparatus are provided for constructing tissue from cells or other objects by application of temporally and spatially controlled electric fields. Electric field applicators expose a substrate (32) to the electric field controlled to affect the processing medium (28) to achieve a processing effect on the construction of tissue on the substrate (32). Electrical bias is selected to interact with dipole properties of the medium (28) to control the movement of suspended dielectrophoretic cells or other particles in the medium (28) or at the substrate (32). The motion of suspended particles may be affected to cause suspended particles of different properties to follow different paths in the processing medium (28), which may be used to cause the suspended particles to be sorted. The processing medium (28) and electrical bias may be selected to affect the structure, or orientation, of one or more layers on the substrate (32).

대표
청구항
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1. An electric field processing system for building a tissue from cells, comprising: a processing chamber, the processing chamber having a first end with a substrate holder positioned therein to receive a substrate upon which the tissue is to be built;an electric field applicator disposed proximate the substrate holder and configured to apply an electric field to a substrate positioned thereon in a processing region of the processing chamber proximate thereto;a distributing bias unit configured to supply an electrical bias to the at least one electric field applicator;a fluid delivery system for delivering cells and fluids used in building the tissue;a manipulator for positioning the electric field applicator with respect to a substrate positioned on the substrate holder;at least one power supply for providing electric power to the distributing bias unit; anda control system for controlling the electric field applicator, manipulator, and the at least one power supply. 2. The processing system of claim 1 wherein: the electric field applicator is located at a second end of the processing chamber opposite the substrate holder. 3. The processing system of claim 1, wherein the at least one electric field applicator is configured to impart a predetermined behavior to the cells or fluids or both, and is interchangeable with another electric field applicator configured to impart a different behavior on the cells or fluids or both. 4. The processing system of claim 1, further comprising: a cell reservoir, for providing the cells for building of the tissue, the cell reservoir being in fluid communication with the fluid delivery system. 5. The processing system of claim 1, further comprising: a hydrogel reservoir, for providing a hydrogel to the fluid delivery system. 6. The processing system of any of claim 1, further comprising: a stabilization liquid reservoir, for providing a stabilizing liquid to the fluid delivery system. 7. The processing system of claim 1, further comprising: a flush liquid reservoir, for providing a flush liquid to the fluid delivery system. 8. The processing system of claim 1, further comprising: at least one source of electromagnetic radiation, configured for irradiating a substrate positioned on the substrate holder, or the tissue, or both. 9. The processing system of claim 8, wherein the at least one source of electromagnetic radiation is an infrared radiation source. 10. The processing system of claim 8, wherein the at least one source of electromagnetic radiation is an ultraviolet radiation source. 11. The processing system of claim 8, wherein the at least one source of electromagnetic radiation is a visible light radiation source. 12. The processing system of claim 8, wherein the at least one source of electromagnetic radiation is a microwave radiation source. 13. The processing system of claim 1, further comprising: a temperature control system for spatially and temporally varying the temperature of a substrate positioned on the substrate holder, or the tissue, or both. 14. The processing system of claim 13, wherein the control system controls the temperature control system. 15. The processing system of claim 1, wherein the fluid delivery system comprises at least one microfluidic device. 16. The processing system of claim 1, wherein the manipulator is configured to vary the distance between the electric field applicator and a substrate positioned on the substrate holder. 17. The processing system of claim 1, wherein the manipulator is configured to vary the azimuthal orientation of the electric field applicator with respect to a substrate positioned on the substrate holder. 18. The processing system of claim 1, wherein the at least one electric field applicator comprises a plurality of microelectrodes, the plurality of microelectrodes being electrically insulated from the processing region. 19. The processing system of claim 1, wherein the electric field is spatially-varying, time-varying, or both. 20. A method of building a tissue from cells, comprising: supplying a processing medium via a processing chamber having a first end with a substrate positioned in the first end and upon which tissue is to be built, wherein the processing medium is supplied through a fluid delivery system to a processing region of the processing chamber;supplying cells and fluids through the fluid delivery system to the processing region to be used in building the tissue;applying a first electrical bias to at least one electric field applicator disposed proximate to the substrate by a distributing bias unit to generate a first electric field, the first electric field being configured to controllably select, transport, orient, arrange, or manipulate cells in the processing region to build the tissue on the substrate;positioning the at least one electric field applicator with respect to the substrate by a manipulator;providing electric power to the distributing bias with at least one power supply; andcontrolling the at least one electric field applicator, manipulator, and the at least one power supply with a control system. 21. The method of claim 20, further comprising: applying a second electrical bias by the distributing bias unit to the at least one electric field applicator to generate a second electric field concurrent with the first electric field, the second electric field being different than the first electric field, and configured to controllably select, transport, orient, arrange, or manipulate cells in the processing region to build the tissue on the substrate from the first and second electric fields. 22. The method of claim 20, further comprising: positioning the at least one electric field applicator, using the manipulator, at a pre-set distance from the substrate. 23. The method of claim 20, further comprising: positioning the at least one electric field applicator, using the manipulator, at a pre-set azimuthal orientation with respect to the substrate. 24. The method of claim 20, further comprising: irradiating the tissue with at least one of infrared radiation, visible light radiation, ultraviolet radiation, and microwave radiation. 25. A method for building a tissue from cells, comprising: positioning a substrate on a first end of a processing chamber and in a processing region of the processing chamber to build tissue upon the substrate from the cells;supplying a processing medium through a fluid delivery system to the processing region to transport the cells and fluid via the processing medium into the processing region to build tissue upon the substrate;applying a plurality of electrical biases concurrently to a plurality of electrodes positioned in the processing region to generate a plurality of electric fields in the processing region with each electric field generated by a corresponding electrode; andadjusting at least one electrical bias to differ from the plurality of electrical biases to generate at least one electric field that differs from the plurality of electric fields to select, transport, orient, arrange, or manipulate cells in the processing region to build the tissue on the substrate.

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System and method for tissue construction using an electric field applicator

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