In one aspect, the present invention features a machine for the production of a solid dosage form wherein the machine is adapted to form a dosage form between a first forming tool and a second forming tool within a forming cavity and wherein the first RF electrode and the second RF electrode are arr
In one aspect, the present invention features a machine for the production of a solid dosage form wherein the machine is adapted to form a dosage form between a first forming tool and a second forming tool within a forming cavity and wherein the first RF electrode and the second RF electrode are arranged within the machine such that when RF energy is applied between the first RF electrode and the second RF electrode, the RF energy passes through the portion of the forming cavity adapted to form the dosage form.
대표청구항▼
1. A machine for the production of a solid dosage form, said machine comprising: (a) a die block having one or more forming cavities each having an inner wall, a first opening at the surface of one side of said die block, and a second opening at the surface on the opposite side of said die block;(b)
1. A machine for the production of a solid dosage form, said machine comprising: (a) a die block having one or more forming cavities each having an inner wall, a first opening at the surface of one side of said die block, and a second opening at the surface on the opposite side of said die block;(b) one or more first dosing nozzles adapted to both measure and hold in place an amount of a first powder blend within said one or more first dosing nozzles using negative pressure, move said measured amount of said first powder blend to one of said one or more forming cavities, and discharge said measured amount of said first powder blend within said one of said one or more forming cavity using positive pressure;(d) one or more first forming tools each adapted to move into one of said cavities through the first opening of said forming cavity;(e) one or more second forming tools each adapted to move adjacent to one of said second openings or into one of said cavities through the second opening of said forming cavity;(f) at least one first RF electrode operably associated with said one or more first forming tools, said one or more second forming tools, or said inner wall of said one or more forming cavities; and(g) at least one second RF electrode operably associated with said one or more first forming tools, said one or more second forming tools, or said inner wall of said one or more forming cavities;wherein said machine is configured such that when RF energy is applied between one or said at least one first RF electrode and one or said at least one second RF electrode, said RF energy passes through the portion of a forming cavity between one of said one or more first forming tools and one or said one or more second forming tools such that said RF energy is capable of heating said measured amount of said first powder blend deposited into said forming cavity by one of said one or more first dosing nozzles such that said measured amount of said first powder blend binds into said solid dosage form. 2. A machine if claim 1, wherein said machine further comprises an RF energy source in communication with said first RF electrode and said second RF electrode. 3. A machine of claim 1, wherein said first RF electrode is operably associated with said one or more first forming tools, said second RF electrode is operably associated with said one or more second forming tools, and the portion of the inner wall of said forming cavity which is adapted to form said dosage form is insulative to said RF energy. 4. A machine of claim 1, wherein said first RF electrode is operably associated with said one or more first forming tools and second RF electrode is operably associated with the portion of said inner wall of said one or more forming cavities that is adapted to form said dosage form. 5. A machine of claim 1, wherein said first RF electrode is operably associated with a first portion of said inner wall of said one or more forming cavities that is adapted to form said dosage form and second RF electrode is operably associated with a second portion of said inner wall of said one or more forming cavities that is adapted to form said dosage form. 6. A machine of claim 1, wherein said die block comprises at least six of said forming cavities. 7. A machine of claim 1, wherein said first forming tool or said second forming tool is further adapted to eject said tablet from said forming cavity. 8. A machine for the production of a solid dosage form, said machine comprising: (a) a die block having one or more forming cavities each having an inner wall, a first opening at the surface of one side of said die block, and a second opening at the surface on the opposite side of said die block;(b) one or more first dosing nozzles adapted to both measure and hold in place an amount of a first powder blend within said one or more first dosing nozzles using negative pressure, move said measured amount of said first powder blend to one of said one or more forming cavities, and discharge said measured amount of said first powder blend within said one of said one or more forming cavity using positive pressure;(c) one or more second dosing nozzles adapted to both measure and hold in place an amount of a second powder blend within said one or more second dosing nozzles using negative pressure, move said measured amount of said second powder blend to said one of said one or more forming cavities, and discharge said measured amount of said second powder blend within said one of said one or more forming cavity using positive pressure;(d) one or more first forming tools each adapted to move into one of said cavities through the first opening of said forming cavity;(e) one or more second forming tools each adapted to move adjacent to one of said second openings or into one of said cavities through the second opening of said forming cavity;(f) at least one first RF electrode operably associated with said one or more first forming tools, said one or more second forming tools, or said inner wall of said one or more forming cavities; and(g) at least one second RF electrode operably associated with said one or more first forming tools, said one or more second forming tools, or said inner wall of said one or more forming cavities;wherein said machine is configured such that when RF energy is applied between one or said at least one first RF electrode and one or said at least one second RF electrode, said RF energy passes through the portion of a forming cavity between one of said one or more first forming tools and one or said one or more second forming tools such that said RF energy is capable of heating said measured amount of said first powder blend deposited into said forming cavity by one of said one or more first dosing nozzles and said measured amount of said second powder blend deposited into said forming cavity by one of said one or more second dosing nozzles such that said measured amount of said first powder blend and said measured amount of said second powder blend binds into said solid dosage form. 9. A machine if claim 8, wherein said machine further comprises an RF energy source in communication with said first RF electrode and said second RF electrode. 10. A machine of claim 8, wherein said first RF electrode is operably associated with said one or more first forming tools, said second RF electrode is operably associated with said one or more second forming tools, and the portion of the inner wall of said forming cavity which is adapted to form said dosage form is insulative to said RF energy. 11. A machine of claim 8, wherein said first RF electrode is operably associated with said one or more first forming tools and second RF electrode is operably associated with the portion of said inner wall of said one or more forming cavities that is adapted to form said dosage form. 12. A machine of claim 8, wherein said first RF electrode is operably associated with a first portion of said inner wall of said one or more forming cavities that is adapted to form said dosage form and second RF electrode is operably associated with a second portion of said inner wall of said one or more forming cavities that is adapted to form said dosage form. 13. A machine of claim 8, wherein said die block comprises at least six of said forming cavities. 14. A machine of claim 8, wherein said first forming tool or said second forming tool is further adapted to eject said tablet from said forming cavity. 15. A machine for the production of a solid dosage form, said machine comprising: (a) a die block having one or more forming cavities each having an inner wall, a first opening at the surface of one side of said die block, and a second opening at the surface on the opposite side of said die block, wherein said forming cavity further comprises a movable divider adapted to form a first chamber and a second chamber within said forming cavity;(b) one or more first dosing nozzles adapted to both measure and hold in place an amount of a first powder blend within said one or more first dosing nozzles using negative pressure, move said measured amount of said first powder blend to one of said one or more forming cavities, and discharge said measured amount of said first powder blend within one of said first chamber using negative pressure;(c) one or more second dosing nozzles adapted to both measure and hold in place an amount of a second powder blend within said one or more second dosing nozzles using negative pressure, move said measured amount of said second powder blend to said one of said one or more forming cavities, and discharge said measured amount of said second powder blend within said one of said second chamber using negative pressure;(d) one or more first forming tools each adapted to move into one of said cavities through the first opening of said forming cavity;(e) one or more second forming tools each adapted to move adjacent to one of said second openings or into one of said cavities through the second opening of said forming cavity;(f) at least one first RF electrode operably associated with said one or more first forming tools, said one or more second forming tools, or said inner wall of said one or more forming cavities; and(g) at least one second RF electrode operably associated with said one or more first forming tools, said one or more second forming tools, or said inner wall of said one or more forming cavities;wherein said machine is configured such that when RF energy is applied between one or said at least one first RF electrode and one or said at least one second RF electrode, said RF energy passes through the portion of a forming cavity between one of said one or more first forming tools and one or said one or more second forming tools such that said RF energy is capable of heating said measured amount of said first powder blend deposited into said first chamber of said forming cavity by one of said one or more first dosing nozzles and said measured amount of said second powder blend deposited into said second chamber of said forming cavity by one of said one or more second dosing nozzles such that said measured amount of said first powder blend and said measured amount of said second powder blend binds into said solid dosage form and further wherein said machine is adapted to remove said movable divider from within said forming cavity such that said first powder blend contacts said second powder blend within said forming cavity prior to said binding step. 16. The machine of claim 15, wherein said movable divider is curved. 17. A machine if claim 15, wherein said machine further comprises an RF energy source in communication with said first RF electrode and said second RF electrode. 18. A machine of claim 15, wherein said first RF electrode is operably associated with said one or more first forming tools, said second RF electrode is operably associated with said one or more second forming tools, and the portion of the inner wall of said forming cavity which is adapted to form said dosage form is insulative to said RF energy. 19. A machine of claim 15, wherein said first RF electrode is operably associated with said one or more first forming tools and second RF electrode is operably associated with the portion of said inner wall of said one or more forming cavities that is adapted to form said dosage form. 20. A machine of claim 15, wherein said first RF electrode is operably associated with a first portion of said inner wall of said one or more forming cavities that is adapted to form said dosage form and second RF electrode is operably associated with a second portion of said inner wall of said one or more forming cavities that is adapted to form said dosage form. 21. A machine of claim 15, wherein said die block comprises at least six of said forming cavities. 22. A machine of claim 15, wherein said first forming tool or said second forming tool is further adapted to eject said tablet from said forming cavity.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (113)
Rudnic Edward M. ; Belendiuk George W. ; McCarty John ; Wassink Sandra ; Couch Richard A., Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine.
Izzo Henry J. (Naperville IL) Moran Martin J. (Oak Lawn IL) Wheeler Frederick G. (Poplarville MS), Antacid tablets and processes for their preparation.
Van Lengerich Bernhard H. (Ringwood NJ) Thorniley Denise (Maywood NJ) Palermo John (Crestwood NY) Koppa Daniel A. (Bloomfield NJ), Apparatus and methods for the production of three-dimensional food products.
Collins Alfred L. (Powhatan VA) Cutright Edwin L. (Powhatan VA) DeBlasio James A. (Midlothian VA) Dickerson Richard H. (Powhatan VA) Kean ; Jr. Billy J. (Chesterfield VA) Ritt ; Sr. Renzer R. (Richmo, Apparatus and methods for transferring and metering granular material.
Choi Tak-Ming (Troy NY) Konrad Adalbert (Glenville NY) Kim Bang M. (Schenectady County NY) Carroll ; Sr. James J. (Ballstone Lake NY), Apparatus for deforming thermoplastic material using RF heating.
Smith, Barry S.; Garthaffner, Martin T.; Ercelebi, Ahmet; Spiers, Steven; Straight, Jeremy, Applicator wheel for filling cavities with metered amounts of particulate material.
Puglia Wayne J. (Bellerose Village NY) Patanasinth Kanit J. (Tarrytown NY) Lombardo Andrew T. (Bronx NY) Beam John E. (Norwalk CT) Mackay Donald A. M. (Pleasantville NY), Compressed chewable antacid tablet and method for forming same.
Isaac Ghebre-Sellassie ; Matthew J. Mollan, Jr. ; Nitin Pathak ; Mayur Lodaya ; Mebrahtu Fessehaie, Continuous production of pharmaceutical granulation.
Hendrickson Dennis L. (Overland Park KS) Dimmitt Dan C. (Belton MO) Williams Mark S. (Kansas City MO) Skultety Paul F. (Leawood KS) Baltezor Michael J. (Lees Summit MO), Diltiazem formulation.
Gergely Gerhard (Gartengasse 8 Vienna ; A-1050 ATX) Gergely Thomas (Gartengasse 8 Vienna ; A-1050 ATX) Gergely Irmgard (Gartengasse 8 Vienna ; A-1050 ATX), Disintegrating tablet and process for its preparation.
Mackles Leonard (New York NY), Edible unit dosage form consisting of outer mannitol shell and inner liquid or gel center and method for manufacturing t.
Wei You C. (Randolph NJ) Cherukuri Subraman R. (Towaco NJ) Hriscisce Frank (Long Island City NY) Piccolo Dominic J. (Hopatcong NJ) Bilka Kenneth P. (Floral Park NY), Elastomer encapsulation of flavors and sweeteners, long lasting flavored chewing gum compositions based thereon and proc.
Schobel Alexander M. (Whitehouse Station NJ) Yang Robert K. (Randolph NJ), Encapsulated sweetener composition for use with chewing gum and edible products.
Sowden, Harry S.; Bunick, Frank J.; Luber, Joseph R.; Kriksunov, Leo B.; Szymczak, Christopher E., Machine for the manufacture of dosage forms utilizing radiofrequency energy.
Koll, Gregory E.; Sowden, Harry S.; Luber, Joseph R.; Kriksunov, Leo B.; Bunick, Frank J.; Chen, Jen-Chi; Olsson, Roland; Szymczak, Christopher E., Manufacture of chewing gum product with radiofrequency.
Chen, Jen-Chi; Sowden, Harry S.; Luber, Joseph R.; Kriksunov, Leo B.; Bunick, Frank J.; Szymczak, Christopher E.; Koll, Gregory E., Manufacture of lozenge product with radiofrequency.
Chen, Jen-Chi; Sowden, Harry S.; Luber, Joseph R.; Kriksunov, Leo B.; Bunick, Frank J.; Szymczak, Christopher E.; Koll, Gregory E., Manufacture of lozenge product with radiofrequency.
Kriksunov, Leo B.; Sowden, Harry S.; Luber, Joseph R.; Bunick, Frank J., Manufacture of tablet having immediate release region and sustained release region.
Bunick, Frank J.; Sowden, Harry S.; Luber, Joseph R.; Kriksunov, Leo B.; Szymczak, Christopher E., Manufacture of tablet in a die utilizing radiofrequency energy and meltable binder.
Szymczak, Christopher E.; Bunick, Frank J.; Sowden, Harry S.; Luber, Joseph R.; Kriksunov, Leo B., Manufacture of variable density dosage forms utilizing radiofrequency energy.
Piehler Henry R. (Pittsburgh PA) Richter John M. (Pittsburgh PA) Kuhni Michael (Acme PA), Method and apparatus for inductively heating powders or powder compacts for consolidation.
Lee, Chang Hyun; Woo, Jong Soo; Yi, Hong Gi; Kim, Kyeong Soo; Yim, Ho Taek, Method for preparing rapidly disintegrating formulation for oral administration and apparatus for preparing and packing the same.
Kuzee Hendrika C. (Oost Souburg NLX) Hoeks Theodorus L. (Bergen Op Zoom NLX) Visschedijk Paulus J. (Roosendaal NLX), Method for the preparation of polysaccharide derivatives.
Stben Werner (Bchen DEX) Hinzpeter Jrgen (Schwarzenbek DEX) Deusch Rudolf (Schwarzenbek DEX) Friedrichs Konrad (Schwarzenbek DEX), Method for the production of tablets and a tablet press.
Stben Werner (Bchen DEX) Hinzpeter Jrgen (Schwarzenbek DEX) Deusch Rudolf (Schwarzenbek DEX) Friedrichs Konrad (Schwarzenbek DEX), Method of producing tablets in a press and a tablet press for carrying out the method.
Burnside Beth A. ; Guo Xiaodi ; Fiske Kimberly ; Couch Richard A. ; Treacy Donald J. ; Chang Rong-Kun ; McGuinness Charlotte ; Rudnic Edward M., Oral pulsed dose drug delivery system.
Gole Dilip J. (Ann Arbor MI) Levinson R. Saul (Chesterfield MO) Wilkinson Paul K. (Ann Arbor MI) Davies J. Desmond (Grosse Pointe Farms MI), Pharmaceutical and other dosage forms.
Gole Dilip J. (Ann Arbor MI) Levinson R. Saul (Chesterfield MO) Wilkinson Paul K. (Ann Arbor MI) Davies J. Desmond (Grosse Pointe Farms MI), Pharmaceutical and other dosage forms.
Schneider Gerhard (Baldham DEX) Stanislaus Fritz (Munich DEX) Hofer Josef M. (Grafing DEX) Heese Gert-Ulfert (Munich DEX) Huber Hans-Joachim (Munich DEX), Pharmaceutical formulation as well as a process for its preparation.
Login Robert B. (Oakland NJ) Tazi Mohammed (Marietta GA) Chuang Jui-Chang (Wayne NJ) Haldar Rama K. (Randolph NJ) Jaiswal Dinesh (Butler NJ) Wu Chi-San (Wayne NJ), Pharmaceutical tablet with PVP having enhanced drug dissolution rate.
Myers Garry L. (Reston VA) Battist Gerald E. (Reston VA) Fuisz Richard C. (Great Falls VA), Process and apparatus for making rapidly dissolving dosage units and product therefrom.
Cherukuri Subraman R. (Towner NJ) Myers Garry L. (Reston VA) Battist Gerald E. (Reston VA) Fuisz Richard C. (Great Falls VA), Process for forming quickly dispersing comestible unit and product therefrom.
Roche Edward J. (Paoli PA) Reo Joseph P. (Harleysville PA), Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets.
Morris William M. (Rancho Palos Verdes CA) Witzel Frank (Saratoga Springs NY) Puglia Wayne J. (Bayville NY) Mackay Donald A. M. (Pleasantville NY) Clark K. Warren (Brewster NY) Patanasinth Kanit J. (, Soft homogeneous antacid tablet.
Mizumoto, Takao; Masuda, Yoshinori; Kajiyama, Atsushi; Yanagisawa, Masahiro; Nyshadham, Janaki Ram, Tablets quickly disintegrating in the oral cavity and process for producing the same.
Alkire Todd G. (Crystal MN) Sanftleben Ronald A. (Maple Grove MN) Schuehle Steven S. (Maple Grove MN), Taste masking microparticles for oral dosage forms.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.