The invention relates to a device of ocular iontophoresis for delivering active substances, comprising a reservoir having an outer wall and a hollow body at least partly delimited by the outer wall, wherein the hollow body is capable of receiving an electrical conductive medium and active substances
The invention relates to a device of ocular iontophoresis for delivering active substances, comprising a reservoir having an outer wall and a hollow body at least partly delimited by the outer wall, wherein the hollow body is capable of receiving an electrical conductive medium and active substances contained in the medium and has an outlet defining a surface, so-called “application surface”, intended to received a determine part of an eyeball surface, the application surface being at least partly limited by an outer line concave towards the optical axis of the eyeball, wherein the outer wall extends from the outer line with a global outwardly with respect to the said optical axis.
대표청구항▼
1. An ocular iontophoresis device for delivering active substances to an eyeball, the ocular iontophoresis device comprising: an active electrode;a reservoir having an inlet comprising a rigid material for maintaining a shape of the active electrode and an outlet comprising a flexible material suita
1. An ocular iontophoresis device for delivering active substances to an eyeball, the ocular iontophoresis device comprising: an active electrode;a reservoir having an inlet comprising a rigid material for maintaining a shape of the active electrode and an outlet comprising a flexible material suitable for making contact with the eyeball, the inlet and the outlet each having a respective shape, wherein the area of the inlet shape is greater than the area of the outlet; andwherein the outlet defines an application surface adapted to receive a predetermined part of an eyeball surface, wherein an area of the active electrode (“Se”) is greater than an area of the application surface (“Sa”) to provide an increased electric field intensity by a value proportionate to the ratio “Se/Sa”, the application surface configured in the shape of at least one of an entire ring, a disk, a portion of a ring, an ellipse, or eye-shaped. 2. The ocular iontophoresis device of claim 1, wherein the application surface is designed for covering at least a portion of the cornea of the eyeball. 3. The ocular iontophoresis device of claim 1, wherein the application surface is designed for covering at least a portion of the cornea of the eyeball and at least a portion of the sclera of the eyeball. 4. An ocular iontophoresis device according to claim 1, wherein the reservoir comprises: a first container for containing active substances and the electrically conductive medium; and a second container for containing electrically conductive elements; wherein the first and second containers are separated by a semi-permeable membrane permeable to the electrically conductive elements and non-permeable to the active substances. 5. The ocular iontophoresis device of claim 1, further comprising an electrically conductive medium contained in the reservoir, wherein the electrically conductive medium is selected from the group consisting of an electrically conductive liquid and a gel. 6. The ocular iontophoresis device of claim 1, wherein the active electrode has globally the same shape as the bottom of the hollow body. 7. The ocular iontophoresis device of claim 1, wherein the active electrode includes a through opening. 8. The ocular iontophoresis device of claim 1, further comprising active substances contained in the reservoir. 9. The ocular iontophoresis device of claim 8, wherein the active substances comprising a medication, a drug, or any combination thereof. 10. The ocular iontophoresis device of claim 1, further comprising an exterior wall and an interior wall, the exterior wall and the interior wall define the reservoir. 11. The ocular iontophoresis device of claim 10, wherein the application surface is designed for covering at least a portion of the sclera of the eyeball. 12. The ocular iontophoresis device of claim 11, wherein the application surface is designed for covering in projection at least a portion of the ciliary body of the eyeball. 13. The ocular iontophoresis device of claim 12, wherein the application surface is designed for covering in projection at least a portion of the anterior pars plicata ciliaris of the eyeball. 14. The ocular iontophoresis device of claim 12, wherein the application surface is designed for covering in projection at least a portion of the posterior pars plana ciliaris of the eyeball. 15. The ocular iontophoresis device of claim 10, wherein the reservoir further comprising: at least two compartments for containing different active substances; andwherein the active electrode is subdivided into at least two active electrode portions, each respective active electrode portion disposed in the respective compartment of the at least two compartments. 16. The ocular iontophoresis device of claim 10, wherein the application surface is designed for covering at least a portion of the cornea of the eyeball and at least a portion of the sclera of the eyeball.
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이 특허에 인용된 특허 (16)
Wallace Larry B. (1139 Ellis Hollow Rd. Ithaca NY 14850) Digney Kevin A. (7130 Woodchuck Hill Rd. Fayetteville NY 13066), Apparatus and method for ocular treatment.
Petelenz Tomasz J. (Salt Lake City UT) Stephen Robert L. (Salt Lake City UT) Jacobsen Stephen C. (Salt Lake City UT), Methods and apparatus for iontophoresis application of medicaments.
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