Movement disorder therapy system and methods of tuning remotely, intelligently and/or automatically
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/372
A61N-001/36
A61B-005/11
A61N-001/05
A61B-005/00
G06F-019/00
출원번호
US-0022376
(2013-09-10)
등록번호
US-9238142
(2016-01-19)
발명자
/ 주소
Heldman, Dustin A
Pulliam, Christopher L
Giuffrida, Joseph P
Mera, Thomas O
출원인 / 주소
Great Lakes NeuroTechnologies Inc.
대리인 / 주소
Kolkowski, Brian
인용정보
피인용 횟수 :
5인용 특허 :
19
초록▼
The present invention relates to methods for remotely and intelligently tuning movement disorder of therapy systems. The present invention still further provides methods of quantifying movement disorders for the treatment of patients who exhibit symptoms of such movement disorders including, but not
The present invention relates to methods for remotely and intelligently tuning movement disorder of therapy systems. The present invention still further provides methods of quantifying movement disorders for the treatment of patients who exhibit symptoms of such movement disorders including, but not limited to, Parkinson's disease and Parkinsonism, Dystonia, Chorea, and Huntington's disease, Ataxia, Tremor and Essential Tremor, Tourette syndrome, stroke, and the like. The present invention yet further relates to methods of remotely and intelligently or automatically tuning a therapy device using objective quantified movement disorder symptom data to determine the therapy setting or parameters to be transmitted and provided to the subject via his or her therapy device. The present invention also provides treatment and tuning intelligently, automatically and remotely, allowing for home monitoring of subjects.
대표청구항▼
1. A method of continuous or periodic tuning of a movement disorder therapy system comprising steps of: having a subject wear a movement disorder diagnostic device during activities of daily living, the subject having a deep brain stimulation (DBS) device with a first level of DBS parameters, and th
1. A method of continuous or periodic tuning of a movement disorder therapy system comprising steps of: having a subject wear a movement disorder diagnostic device during activities of daily living, the subject having a deep brain stimulation (DBS) device with a first level of DBS parameters, and the movement disorder diagnostic device comprising at least one physiological or movement sensor having a signal;identifying or determining in real-time with a processor what activity of daily living the subject is performing, andmotor symptoms of a movement disorder or side effects of a treatment the subject is undergoing that the subject is suffering or has suffered based at least in part on the signal(s) from the at least one physiological or movement sensor and at least in part on the identified determined activity of daily living;measuring and quantifying a severity of the identified or determined motor symptoms or side effects with a processor based at least in part on the signal(s) from the at least one physiological or movement sensor while the subject is wearing the diagnostic device in real-time;calculating, with the processor, at least two optional groups of DBS parameters based at least in part on the measured and quantified severity of the identified or determined motor symptoms or side effects, each optional group addressing a separate identified or detected symptom or side effect in real-time;having the subject select one of the at least two optional groups of DBS parameters based on the subject's activity of daily living;transmitting the selected optional group of DBS parameters to the subject's DBS device; andentering the selected optional group of DBS parameters into the subject's DBS device such that the subject's DBS device operates under the selected optional group of DBS parameters,wherein data corresponding to the subject's measured and quantified motor symptoms is displayed in a tuning map that is a two-dimensional representation of a three-dimensional graph visually for review, and the displayed data and second level of DBS parameters is reviewed and approved by a clinician, physician or technician before being entered into the subject's therapy device. 2. The method of claim 1, wherein the movement disorder diagnostic device has a real-time average intraclass correlation (ICC) of at least 0.60. 3. The method of claim 2, wherein the movement disorder diagnostic device has a real-time average minimum detectable change (MDC) of at least 25% or less. 4. The method of claim 1, wherein the steps of measuring and quantifying severity, transmitting data and calculating at least two optional groups of DBS parameters are performed over a measurement time of less than about 10 minutes. 5. A method of tuning a movement disorder therapy system comprising steps of: having a subject wear a movement disorder diagnostic device, the subject having a deep brain stimulation (DBS) device with a first level of DBS parameters, the movement disorder diagnostic device comprising at least one physiological or movement sensor having a signal;measuring and quantifying a severity of motor symptoms of the subject based at least in part on the signal from the at least one physiological or movement sensor(s) in real-time;transmitting data corresponding to the severity of the subject's measured and quantified motor symptoms to a clinician, physician or technician at a remote location, the data being represented in the form of a tuning map that is a two-dimensional representation of a three-dimensional graph;having the clinician, physician or technician determine, based at least in part on the tuning map, a second level of DBS parameters;transmitting the second level of DBS parameters to the subject's DBS device; andentering the second level of DBS parameters into the subject's DBS device such that the subject's DBS device operates under the second level of DBS parameters. 6. The method of claim 5, wherein the movement disorder diagnostic device has a real-time average intraclass correlation (ICC) of at least 0.60. 7. The method of claim 5, wherein the movement disorder diagnostic device has a real-time average minimum detectable change (MDC) of at least 25% or less. 8. The method of claim 5, wherein the second level of DBS parameters corresponds to an increased ability for the subject to perform at least one activity of daily living. 9. The method of claim 5, wherein the clinician, physician or technician is caused to determine at least two optional groups of DBS parameters, each optional group corresponding to a different desired outcome or restraint, and further comprising the step of selecting one of the at least two optional groups to be transmitted and entered into the subject's therapy device such that the subject's therapy device operates under the selected group of parameters. 10. The method of claim 9, wherein the at least two optional groups of DBS parameters each correspond to a different motor symptom or side effect, and the selected group of parameters corresponds to a quantifiable decrease in the severity of the motor symptom or side effect corresponding to the selected group. 11. The method of claim 9, wherein the data corresponding to the subject's measured and quantified motor symptoms and the selected optional group of DBS parameters are displayed visually for review in a tuning map that is a two-dimensional representation of a three-dimensional graph, and the tuning map and second level of DBS parameters are reviewed and approved by a clinician, physician or technician before being entered into the subject's therapy device. 12. The method of claim 5, wherein the data and second level of DBS parameters are reviewed and approved by a clinician, physician or technician before being entered into the subject's therapy device.
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이 특허에 인용된 특허 (19)
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Gliner,Bradford Evan; Balzer,Jeffrey; Firlik,Andrew D., Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators.
Gliner,Bradford Evan, Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of Parkinson's disease and/or other movement disorders.
Heldman, Dustin A.; Giuffrida, Joseph P., Wearable, unsupervised transcranial direct current stimulation (tDCS) device for movement disorder therapy, and method of using.
Heldman, Dustin A; Pulliam, Christopher L; Giuffrida, Joseph P; Mera, Thomas O, Movement disorder therapy system and methods of tuning remotely, intelligently and/or automatically.
Heldman, Dustin A; Pulliam, Christopher L; Giuffrida, Joseph P; Mera, Thomas O, Movement disorder therapy system, devices and methods, and intelligent methods of tuning.
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