A nanoparticle coated hydrogel may be formed by a method of electrospraying nanoparticles on to a hydrogel surface includes providing a drug and polymer combination in solvent to an inner capillary of a coaxial capillary spray nozzle. A coating with a drug that releases over time may be provided. Op
A nanoparticle coated hydrogel may be formed by a method of electrospraying nanoparticles on to a hydrogel surface includes providing a drug and polymer combination in solvent to an inner capillary of a coaxial capillary spray nozzle. A coating with a drug that releases over time may be provided. Open and closed matrixes may be selectively formed to help modify time release periods.
대표청구항▼
1. An article comprising: a hydrogel; anda nanoparticle coating adhered to the hydrogel, the coating comprising first nanoparticles comprising a first biologically active organic material and a first polymer, the first biologically active material being encapsulated by the first polymer, the first n
1. An article comprising: a hydrogel; anda nanoparticle coating adhered to the hydrogel, the coating comprising first nanoparticles comprising a first biologically active organic material and a first polymer, the first biologically active material being encapsulated by the first polymer, the first nanoparticles having a nominal diameter of less than 500 nanometers. 2. The article of claim 1, wherein the first biologically active organic material comprises a hydrophobic drug. 3. The article of claim 1, wherein the first biologically active material releases from the coating over time when the article is placed in a moist environment. 4. The article of claim 1, wherein the coating further comprises a polymer stabilizing material. 5. The article of claim 1, wherein the first polymer comprises polyurethane, poly(lactide-co-caprolactone), polyisobutylene, or a combination thereof. 6. The article of claim 1, wherein the first biologically active organic material is selected from the group consisting of an anti-inflammatory drug, an antimicrobial drug, an anti-proliferative drug, and combinations thereof. 7. The article of claim 1, wherein the coating further comprises a second biologically active organic material different from the first biologically active organic material. 8. The article of claim 1, wherein the hydrogel is in the form of a preformed hydrogel. 9. The article of claim 1, wherein the coating is in the form of an open matrix. 10. The article of claim 1, wherein the coating is in the form of an intermediate matrix. 11. The article of claim 1, wherein the coating comprises a first layer and a second layer, the first layer comprising the first nanoparticles and the second layer comprising second nanoparticles comprising a second polymer and a second biologically active organic material encapsulated by the second polymer, the second biologically active organic material being different from the first biologically active organic material. 12. The article of claim 11, wherein the first layer exhibits a first morphology and the second layer exhibits a second morphology different from the first morphology. 13. The article of claim 12, wherein the morphology of the first and second layers is independently selected from the group consisting of an open matrix, an intermediate matrix and a closed matrix. 14. The article of claim 1, wherein the first polymer comprises a biodegradable polymer. 15. The article of claim 1, wherein the nanoparticles comprise spherical nanoparticles. 16. The article of claim 1, wherein the nanoparticles comprise elongated fibrous nanoparticles. 17. The article of claim 1, wherein the first biologically active organic material is a drug and the coating comprises a first layer comprising the first nanoparticles, anda second layer comprising second nanoparticles comprising a second drug and a second polymer, the second drug being different from the first drug. 18. The article of claim 17, wherein the first layer exhibits a first release profile and the second layer exhibits a second release profile different from the first release profile. 19. The article of claim 18, wherein the first release profile is rapid relative to the second release profile and the second release profile is delayed relative to the first release profile. 20. The article of claim 17, wherein the first layer releases substantially all of the first drug within no greater than a few hours. 21. The article of claim 20, wherein the second layer releases the second drug over a period of at least two weeks. 22. The article of claim 1, wherein the first nanoparticles are formed by a coaxial nozzle electronanospray device. 23. The article of claim 1, wherein the biologically active organic material comprises a drug and the first nanoparticles are derived from a composition comprising the drug, the first polymer, and a solvent. 24. The article of claim 23, wherein the first nanoparticles are formed by delivering the composition to an inner capillary of a coaxial capillary spray nozzle. 25. The article of claim 1, wherein the nanoparticle coating comprises a layer that is several nanoparticles deep. 26. The article of claim 1, wherein the polymer comprises a hydrophobic polymer.
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Sanford John C. (Geneva NY) Wolf Edward D. (Ithaca NY) Allen Nelson K. (Newfield NY), Biolistic apparatus for delivering substances into cells and tissues in a non-lethal manner.
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Kaufman Stanley L. (New Brighton MN) Zarrin Fahimeh (St. Paul MN) Dorman Frank (Minneapolis MN), Electrospray apparatus for producing uniform submicrometer droplets.
Coffee Ronald A. (Haslemere GB2) Noakes Timothy J. (Selbourne ; near Alton GB2) Bancroft Stephen J. (Haslemere GB2) Bals Edward J. (Bromyard GB2), Electrostatic spraying apparatus.
Noakes Timothy J. (Clwyd GB7) Reed Brian A. (Swindon GB2) Chambers John J. (Gloucestershire GB2), Electrostatic spraying device and method using an alternating polarity high potential.
Jones Lawrence D. (Portage MI) Frey Paul T. (Delton MI) Gleason David D. (Oshtemo Township ; Kalamazoo County MI) Chee Paula P. (Kalamazoo MI) Slightom Jerry L. (Kalamazoo MI), Gas driven microprojectile accelerator and method of use.
Brinegar Chris (587 Locksley Rd. Boulder Creek CA 95006) Gilmore James (6385 Camino Verde Dr. San Jose CA 95119) Johnson Michael (6385 Camino Verde Dr. San Jose CA 95119) Walker Nigel (5385 Broadway , Ice-mediated introduction of substances into biological material.
Kuehnle Adelheid R. (1617 Keeaumoku St. #1008 Honolulu HI 96822) Kuehnle Manfred R. (Waldesruh Rte. 103A ; P.O. Box 1020 New London NH 03257), Magnetophoretic particle delivery method and apparatus for the treatment of cells.
Sanford John C. (Geneva) DeVit Michael J. (Geneva NY) Bruner Ronald F. (Sewell NJ) Johnston Stephen A. (Durham NC), Method and apparatus for introducing biological substances into living cells.
Miller ; Jr. Theodore E. (Midland MI) Schuchardt Bradley C. (Midland MI) Gould Alan R. (Midland MI) Skokut Thomas A. (Champaign IL), Method and apparatus for the acceleration of a propellable matter.
Pletcher Timothy Allen ; Datta Pabitra ; Poux Christopher Just ; McCoy Randall Eugene, Method for electrostatically depositing a medicament powder upon predefined regions of a substrate.
Sanford John C. (Geneva NY) Wolf Edward D. (Ithaca NY) Allen Nelson K. (Newfield NY), Method for transporting substances into living cells and tissues.
Sanford John C. (Geneva NY) Wolf Edward D. (Ithaca NY) Allen Nelson K. (Newfield NY), Method for transporting substances into living cells and tissues and apparatus therefor.
Sanford John C. (Geneva NY) Wolf Edward D. (Ithaca NY) Allen Nelson K. (Newfield NY), Method for transporting substances into living cells and tissues and apparatus therefor.
Juvinall James W. (Sylvania Township ; Lucas County OH) Kock Erhard (Toledo OH), Method of depositing electrostatically charged liquid coating material.
Zhong Sheng-Ping (Farum DKX), Method of providing a substrate with a hydrophilic coating and substrates, particularly medical devices, provided with s.
Yadav, Tapesh; Kostelecky, Clayton; Franke, Evan; Miremadi, Bijan; Au, Ming; Vigliotti, Anthony, Nanomaterials and magnetic media with coated nanostructured fillers and carriers.
Strutt, Peter R.; Kear, Bernard H.; Boland, Ross F., Nanostructured feeds for thermal spray systems, method of manufacture, and coatings formed therefrom.
Ginaven Robert O. (Encinitas CA) Facciotti Daniel (Davis CA), Needle array and method of introducing biological substances into living cells using the needle array.
Ripoll,Antonio Barrero; Ganan Calvo,Alfonso M.; Loscertales,Ignacio Gonzalez; Bon,Raul Cortijo; Marquez,Manuel, Production of capsules and particles for improvement of food products.
Kennedy Joseph P. (Akron OH) Puskas Judit E. (Akron OH) Kaszas Gabor (Akron OH) Hager William G. (Akron OH), Thermoplastic elastomers of isobutylene and process of preparation.
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