Modified polynucleotides encoding SIAH E3 ubiquitin protein ligase 1
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C07K-014/47
C12N-009/00
출원번호
US-0107105
(2013-12-16)
등록번호
US-9255129
(2016-02-09)
발명자
/ 주소
Chakraborty, Tirtha
de Fougerolles, Antonin
출원인 / 주소
MODERNA THERAPEUTICS, INC.
대리인 / 주소
DT Ward, PC
인용정보
피인용 횟수 :
1인용 특허 :
395
초록
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
대표청구항▼
1. An mRNA encoding amino acid 17 to 298 of SEQ ID NO: 8363, wherein said mRNA nucleic acid comprises a coding region, said coding region having at least 80% identity to SEQ ID NO: 33695. 2. The mRNA of claim 1, wherein the mRNA comprises at least one untranslated region 5′ relative to the coding re
1. An mRNA encoding amino acid 17 to 298 of SEQ ID NO: 8363, wherein said mRNA nucleic acid comprises a coding region, said coding region having at least 80% identity to SEQ ID NO: 33695. 2. The mRNA of claim 1, wherein the mRNA comprises at least one untranslated region 5′ relative to the coding region and at least one untranslated region 3′ relative to the coding region. 3. The mRNA of claim 2, wherein the 5′ untranslated region is heterologous to the coding region of the mRNA. 4. The mRNA of claim 2, wherein the 3′ untranslated region is heterologous to the coding region of the mRNA. 5. The mRNA nucleic acid of claim 2, wherein the 5′ untranslated region and the 3′ untranslated region are heterologous to the coding region of the mRNA. 6. The mRNA of claim 2, wherein the mRNA comprises at least two stop codons. 7. The mRNA of claim 1, wherein the coding region is at least 99% identical to SEQ ID NO: 33695. 8. The mRNA of claim 1, wherein the coding region consists of SEQ ID NO: 33695. 9. A pharmaceutical composition comprising the mRNA of claim 1 and a pharmaceutically acceptable excipient. 10. The pharmaceutical composition of claim 9 wherein the pharmaceutically acceptable excipient is selected from a solvent, aqueous solvent, non-aqueous solvent, dispersion media, diluent, dispersion, suspension aid, surface active agent, isotonic agent, thickening or emulsifying agent, preservative, lipid, lipidoids liposome, lipid nanoparticle, core-shell nanoparticles, polymer, lipoplex, peptide, protein, cell, hyaluronidase, and mixtures thereof. 11. A method of producing a protein of interest in a cell, tissue or organism comprising contacting said cell, tissue or organism with the mRNA of claim 1. 12. The method of claim 1, wherein the mRNA comprises at least one untranslated region 5′ relative to the coding region and at least one untranslated region 3′ relative to the coding region. 13. The method of claim 12, wherein the 5′ untranslated region is heterologous to the coding region of the mRNA. 14. The method of claim 12, wherein the 3′ untranslated region is heterologous to the coding region of the mRNA. 15. The method of claim 12, wherein the 5′ untranslated region and the 3′ untranslated region are heterologous to the coding region of the mRNA. 16. The method of claim 12, wherein the mRNA comprises at least two stop codons.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (395)
Dellinger, Douglas J.; Sierzchala, Agnieska; Caruthers, Marvin H.; Dellinger, Geraldine F., 2′-silyl containing thiocarbonate protecting groups for RNA synthesis.
Mahon, Kerry Peter; Love, Kevin Thomas; Levins, Christopher G.; Whitehead, Kathryn Ann; Langer, Robert S.; Anderson, Daniel Griffith, Aminoalcohol lipidoids and uses thereof.
Casimiro, Jose Enrique Montero; Valladares, Josefa Lombardero; Rodriguez, Rolando Perez; Blazquez, Patricia Sierra; Bravo, Rosa Blanca Tormo, Anti-CD6 monoclonal antibodies and their uses.
Andrus William A. (San Francisco CA) McCollum Christie D. (Foster City CA) Zon Gerald (San Carlos CA), Automated system for polynucleotide synthesis and purification.
Andrus William A. (San Francisco CA) McCollum Christie D. (Foster City CA) Zon Gerald (San Carlos CA), Automated system for polynucleotide synthesis and purification.
Brahmbhatt, Himanshu; MacDiarmid, Jennifer; Hulf, Toby, Bacterially derived intact minicells that encompass plasmid free functional nucleic acid for in vivo delivery to mammalian cells.
Ahn, Cheol Hee; Kim, Sung Wan, Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents.
Mark J. Evans ; Louis A. Matis ; Eileen Elliott Mueller ; Steven H. Nye ; Scott Rollins ; Russell P. Rother ; Jeremy P. Springhorn ; Stephen P. Squinto ; Thomas C. Thomas ; James A. Wilkins, C5-specific antibodies for the treatment of inflammatory diseases.
Eberwine James ; Dichter Marc ; Miyashiro Kevin, Characterization of mRNA patterns in neurites and single cells for medical diagnosis and therapeutics.
Darrell R. Anderson ; Nabil Hanna ; Roland A. Newman ; Mitchell E. Reff ; William H. Rastetter, Chimeric and radiolabelled antibodies specific to human CD20 antigen and use thereof for treatment of B-cell lymphoma.
Fewell, Jason G.; Matar, Majed; Rice, Jennifer; Lewis, Danny H.; Anwer, Khursheed, Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases.
Kitabayashi,Masao; Kuroita,Toshihiro; Ishida,Yoshikazu; Komatsubara,Hideyuki; Nishiya,Yoshiaki; Oka,Masanori; Kawamura,Yoshihisa; Imanaka,Tadayuki, Compositions for enhancing DNA synthesis, DNA polymerase-related factors and utilization thereof.
Mark David F. (Danville CA) Lin Leo S. (Fremont CA) Yu Lu Shi-da (Oakland CA) Wang Alice M. (Walnut Creek CA), Cysteine-depleted muteins of biologically active proteins.
Kossmann, Jens; Buttcher, Volker; Welsh, Thomas, DNA sequences coding for enzymes capable of facilitating the synthesis of linear α-1,4 glucans in plants, fungi and microorganisms.
Koops Andries Jurriaan,NLX ; van der Meer Ingrid Maria,NLX ; Van Tunen Arjen Johannus,NLX, DNA sequences encoding carbohydrate polymer synthesizing enzymes and method for producing transgenic plants.
Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Delivery of exogenous DNA sequences in a mammal.
Prausnitz, Mark R.; Allen, Mark G.; Henry, Sebastien; McAllister, Devin V.; Ackley, Donald E.; Jackson, Thomas, Devices and methods for enhanced microneedle penetration of biological barriers.
Zale, Stephen E.; Troiano, Greg; Ali, Mir Mukkaram; Hrkach, Jeff; Wright, James, Drug loaded polymeric nanoparticles and methods of making and using same.
Zale, Stephen E.; Troiano, Greg; Ali, Mir Mukkaram; Hrkach, Jeff; Wright, James, Drug loaded polymeric nanoparticles and methods of making and using same.
Zale, Stephen E.; Troiano, Greg; Ali, Mir Mukkaram; Hrkach, Jeff; Wright, James, Drug loaded polymeric nanoparticles and methods of making and using same.
Mir Lluis (Verrieres-le-Buisson FRX) Orlowski Stephane (Bourg-la-Reine FRX) Siros Michel (Antony FRX), Electric pulse applicator using pairs of needle electrodes for the treatment of biological tissue.
Schrum, Jason P.; Afeyan, Noubar B.; Sieczkiewicz, Gregory J.; Bancel, Stephane; de Fougerolles, Antonin; Elbashir, Sayda M., Engineered nucleic acids encoding a modified erythropoietin and their expression.
Hoffman, Allan S.; Stayton, Patrick; Press, Oliver W.; Murthy, Niren; Reed, Chantal Lackey; Crum, Lawrence A.; Mourad, Pierre D.; Porter, Tyrone M.; Tirrell, David, Enhanced transport using membrane disruptive agents.
Hoffman, Allan S.; Stayton, Patrick; Press, Oliver W.; Tirrell, David; Murthy, Niren; Lackey, Chantal; Crum, Lawrence A.; Mourad, Pierre D.; Porter, Tyrone M., Enhanced transport using membrane disruptive agents.
Wolff Jon A. (Madison WI) Duke David J. (Salem OR) Felgner Philip L. (Rancho Santa Fe CA), Expression of exogenous polynucleotide sequences cardiac muscle of a mammal.
Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon Asher (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert Wallace (Davis CA) Carson Dennis A. (Del Mar CA), Generation of antibodies through lipid mediated DNA delivery.
Makarov, Vladimir L.; Kamberov, Emmanuel; Sleptsova, Irina, Genome walking by selective amplification of nick-translate DNA library and amplification from complex mixtures of templates.
Salfeld Jochen G. ; Allen Deborah J.,GBX ; Hoogenboom Hendricus R. J. M.,BEX ; Kaymakcalan Zehra ; Labkovsky Boris ; Mankovich John A. ; McGuinness Brian T.,GBX ; Roberts Andrew J.,GBX ; Sakorafas Pa, Human antibodies that bind human TNF.alpha..
Van Den Brink, Edward Norbert; De Kruif, Cornelis Adriaan; Throsby, Mark, Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof.
Korman, Alan J.; Srinivasan, Mohan; Wang, Changyu; Selby, Mark J.; Chen, Bingliana; Cardarelli, Josephine M., Human monoclonal antibodies to programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics.
Bendig Mary M.,GBX ; Leger Olivier J.,GBX ; Saldanha Jose,GBX ; Jones S. Tarran,GBX ; Yednock Ted A., Humanized antibodies against leukocyte adhesion molecule VLA-4.
Holtzman,David M.; DeMattos,Ronald; Bales,Kelly R.; Paul,Steven M.; Tsurushita,Naoya; Vasquez,Maximiliano, Humanized antibodies that sequester abeta peptide.
Burke, David J.; Buckley, Shaun E.; Lehrman, Sherwood Russ; O'Connor, Barbara Horsey; Callaway, James; Phillips, Christopher P., Immunoglobulin formulation and method of preparation thereof.
Raz, Eyal; Kornbluth, Richard; Catanzaro, Antonio; Hayashi, Tomoko; Carson, Dennis, Immunomodulatory polynucleotides in treatment of an infection by an intracellular pathogen.
Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Induction of a protective immune response in a mammal by injecting a DNA sequence.
Felgner Philip L. ; Wolff Jon Asher ; Rhodes Gary H. ; Malone Robert Wallace ; Carson Dennis A., Induction of a protective immune response in a mammal by injecting a DNA sequence.
Müller, Rainer H.; Jenning, Volkard; Mader, Karsten; Lippacher, Andreas, Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same.
Cload, Sharon; Diener, John L.; Keefe, Anthony Dominic; Thompson, Kristin, Materials and methods for the generation of transcripts comprising modified nucleotides.
Richard, Robert E.; Strickler, Frederick H.; Schwarz, Marlene C.; Faust, Rudolf; Ranade, Shrirang V.; Helmus, Michael N., Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility.
Fouchier, Ronaldus Adrianus Maria; Van Den Hoogen, Bernadetta Gerarda; Osterhaus, Albertus Dominicus Marcellinus Erasmus; Haller, Aurelia; Tang, Roderick, Metapneumovirus strains and their use in vaccine formulations and sequences.
Laney Maureen (Palo Alto CA) Chen Yan (Palo Alto CA) Ullman Edwin F. (Atherton CA) Hahnenberger Karen M. (Cupertino CA), Method for introducing defined sequences at the 3\end of polynucleotides.
Sutcliffe J. Gregor ; Hasel Karl W., Method for simultaneous identification of differentially expresses mRNAs and measurement of relative concentrations.
Merenkova Irena Nicolaevna,FRX ; Milne Edwards Jean-Baptiste Dumas,FRX, Method for the specific coupling of the cap of the 5' end of an mRNA fragment and preparation of mRNA and complete cDNA.
Davey Cheryl (Toronto CAX) Malek Lawrence T. (Brampton CAX) Lens Peter F. (Amsterdam NLX) Wielaard Frits (Den Bosch NLX), Method for the synthesis of ribonucleic acid (RNA).
Kempf, Dale J.; Bertz, Richard J.; Waring, Jeffrey F., Method for treating a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate.
Kempf,Dale J.; Bertz,Richard J.; Waring,Jeffrey F., Method for treating a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate.
Chenchik Alex ; Zhu York ; Diatchenko Luda ; Siebert Paul, Methods and compositions for full-length cDNA Cloning using a template-switching oligonucleotide.
Chenchik Alex ; Zhu York ; Diatchenko Luda ; Siebert Paul, Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end.
Hudson Geoffrey R. ; Schumm James W. ; Dimond Randall L., Methods and compositions for nucleic acid detection by target extension and probe amplification.
Ali, Mir M.; Hrkach, Jeff; Zale, Stephen E.; Alvarez de Cienfuegos, Luis, Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles.
Forsberg, Goran; Erlandsson, Eva; Antonsson, Per; Walse, Bjorn, Methods for treating a subject having cancer by the administration of a conjugate between a variant staphylococcal entertoxin E superantigen and an antibody that binds to the 5T4 antigen.
Horton,Holly; Parker,Suezanne; Manthorpe,Marston; Felgner,Philip L.; Hartikka,Jukka, Methods for treating cancer using cytokine-expressing polynucleotides.
Sousa Rui ; Jendrisak Jerome J., Methods for using mutant RNA polymerases with reduced discrimination between non-canonical and canonical nucleoside trip.
Philip L. Felgner ; Jon Asher Wolff ; Gary H. Rhodes ; Robert Wallace Malone ; Dennis A. Carson, Methods of delivering a physiologically active polypeptide to a mammal.
Bendig, Mary M.; Leger, Olivier J.; Saldanha, Jose; Jones, Tarran S.; Yednock, Ted A., Methods of inhibiting alpha-4-dependent interactions with VCAM-1 with anti-VLA-4 antibodies.
Dellinger, Douglas J.; Caruthers, Marvin H.; Betley, Jason R., Methods of synthesizing oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection.
Bancel, Stephane; Chakraborty, Tirtha; de Fougerolles, Antonin; Elbashir, Sayda M.; John, Matthias; Roy, Atanu; Whoriskey, Susan; Wood, Kristy M.; Hatala, Paul; Schrum, Jason P.; Ejebe, Kenechi; Ellsworth, Jeff Lynn; Guild, Justin, Modified polynucleotides for the production of biologics and proteins associated with human disease.
Agrawal,Sudhir; Kandimalla,Ekambar R.; Yu,Dong; Bhagat,Lakshmi, Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends.
Schlesinger, Paul; Soman, Neelesh; Lanza, Gregory; Wickline, Samuel A., Nanoparticle delivery systems comprising a hydrophobic core and a lipid/surfactant layer comprising a membrane-lytic peptide.
Bloom, Corey Jay; Crew, Marshall David; Smithey, Daniel Tod; Miller, Warren Kenyon; Morgen, Michael Mark, Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer.
Ginaven Robert O. (Encinitas CA) Facciotti Daniel (Davis CA), Needle array and method of introducing biological substances into living cells using the needle array.
Monforte Joseph Albert (Berkeley CA) Becker Christopher Hank (Menlo Park CA) Shaler Thomas Andrew (San Francisco CA) Pollart Daniel Joseph (Menlo Park CA), Oligonucleotide sizing using immobilized cleavable primers.
Koths Kirston E. (El Cerrito CA) Halenbeck Robert F. (San Rafael CA) Mark David F. (Plainsboro NJ) Nitecti Danutee (Berkeley CA), Oxidation-resistant muteins of Il-2 and other protein.
Pamela Hawley-Nelson ; Jianqing Lan ; PoJen Shih ; Joel A. Jessee ; Kevin P. Schifferli ; Gulilat Gebeyehu ; Valentina C. Ciccarone ; Krista L. Evans, Peptide-enhanced transfections.
Wagner,Hermann; Lipford,Grayson; Heeg,Klaus, Pharmaceutical compositions comprising a polynucleotide and optionally an antigen especially for vaccination.
Miller, Warren K.; Vodak, David T.; Dobry, Daniel E.; Lyon, David K.; Friesen, Dwayne T.; Morgen, Michael M.; Bloom, Corey J.; Smithey, Daniel T., Pharmaceutical compositions of dextran polymer derivatives.
Rozema, David B.; Wakefield, Darren H.; Lewis, David L.; Klein, Jason; Wong, So; Wolff, Jon A.; Hagstrom, James E., Polyconjugates for in vivo delivery of polynucleotides.
Queen Cary L. (Los Altos CA) Schneider William P. (Mountain View CA) Selick Harold E. (Belmont CA), Polynucleotides encoding improved humanized immunoglobulins.
Park, Jong-Sang; Seo, Min-Hyo, Positively charged poly(alpha-(omega-aminoalkyl)lycolic acid) for the delivery of a bioactive agent via tissue and cellular uptake.
Park Jong-Sang,KRX ; Seo Min-Hyo,KRX, Positively charged poly[alpha-(omega-aminoalkyl) glycolic acid] for the delivery of a bioactive agent via tissue and cellular uptake.
Dahl, Gary A.; Jendrisak, Jerome J.; Davydova, Elena K.; Rothman-Denes, Lucia B.; Gerdes, Svetalana Y., Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences.
Van Gelder Russell N. (2200 Divot Dr. Crystal Lake MD 63131) Von Zastrow Mark E. (11570 Buena Vista Dr. Los Altos CA 94022) Barchas Jack D. (1900 Rittenhouse Sq. #18A Philadelphia PA 19103) Eberwine , Process for amplifying a target polynucleotide sequence using a single primer-promoter complex.
Axel Richard (New York NY) Wigler Michael H. (Cold Spring Harbor NY) Silverstein Saul J. (Irvington NY), Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials.
Berninger Mark S. (Gaithersburg) Schuster David M. (Poolesville) Rashtchian Ayoub (Gaithersburg MD), Promoter ligation activated transcription amplification of nucleic acid sequences.
Aitken Bruce G. (Corning NY) Annunziata Frank A. (Horseheads NY) Bartholomew Roger F. (Painted Post NY) Newhouse Mark A. (Corning NY) Powley Mark L. (Campbell NY) Sadd Andrea L. (Corning NY), Rare earth-doped, stabilized cadmium halide glasses.
Apt, Doris; Punnonen, Juha; Brinkman, Alice M., Recombinant dengue virus antigen comprising the capsid protein leader sequence, full-length prM protein, and full-length E protein.
Cabilly Shmuel (Monrovia CA) Heyneker Herbert L. (Burlingame CA) Holmes William E. (Pacifica CA) Riggs Arthur D. (La Verne CA) Wetzel Ronald B. (San Francisco CA), Recombinant immunoglobin preparations.
Khosla Chaitan (Stanford CA) Hopwood David A. (Norwich GB2) Ebert-Khosla Suzanne (Stanford CA) McDaniel Robert (Palo Alto CA) Fu Hong (Stanford CA) Kao Camilla (Stanford CA), Recombinant production of novel polyketides.
Pastan, Ira H.; Onda, Masanori; Nagata, Satoshi; Tsutsumi, Yasuo; Vincent, James J.; Kreitman, Robert J.; Vasmatzis, George; Lee, Byungkook, Reduction of the nonspecific animal toxicity of immunotoxins by mutating the framework regions of the Fv to lower the isoelectric point.
Tsuchiya,Masayuki; Sato,Koh; Bendig,Mary Margaret; Jones,Steven Tarran; Saldanha,Jose William, Reshaped human antibody to human interleukin-6 receptor.
Burg James L. (Foster City CA) Pouletty Philippe J. (Menlo Park CA) Boothroyd John C. (Palo Alto CA), Selective amplification of target polynucleotide sequences.
Mark David F. (Hercules CA) Lin Leo S. (Fremont CA) Yu Lu Shi-Da (Oakland CA), Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-
상세보기
Malek Lawrence T.,CAX ; Sooknanan Roy R.,CAX, Subtractive amplification.
Peery John R. ; Dionne Keith E. ; Eckenhoff James B. ; Landrau Felix A. ; Lautenbach Scott D. ; Magruder Judy A. ; Wright Jeremy C., Sustained delivery of an active agent using an implantable system.
Peery, John R.; Dionne, Keith E.; Landrau, Felix A.; Eckenhoff, James B.; Lautenbach, Scott D.; Magruder, Judy A.; Wright, Jeremy C., Sustained delivery of an active agent using an implantable system.
Anderson Darrell R. ; Hanna Nabil ; Leonard John E. ; Newman Roland A. ; Reff Mitchell E. ; Rastetter William H., Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen.
Anderson Darrell R. ; Hanna Nabil ; Leonard John E. ; Newman Roland A. ; Reff Mitchell E. ; Rastetter William H., Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen.
Anderson Darrell R. ; Hanna Nabil ; Leonard John E. ; Newman Roland A. ; Reff Mitchell E. ; Rastetter William H., Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen.
Zale, Stephen E.; Troiano, Greg; Ali, Mir Mukkaram; Hrkach, Jeff; Wright, James, Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same.
Edwards Stuart D. (Los Altos CA) Lax Ronald G. (Grass Valley CA) Sharkey Hugh R. (Redwood City CA), Transurethral needle delivery device with cystoscope and method for treatment of urinary incontinence.
White, Christine A.; Grillo-López, Antonio J.; Curd, John G.; Desmond-Hellmann, Susan, Treatment of hematologic malignancies associated with circulating tumor cells using chimeric anti-CD20 antibody.
Hedlund, Gunnar; Forsberg, Göran; Wallén-öhman, Marie, Treatment of hyperproliferative disease with superantigens in combination with another anticancer agent.
Zhang, Jing; Dekker, John; van der Kuyl, Antoinette C.; Maas, Jolanda; van Gemen, Bob, Universal nucleic acid amplification system for nucleic acids in a sample.
Schleyer,Siew C.; Jefferson,Anne B.; Abraham,Judith A.; Kavanaugh,W. Michael, Use of NRG4, or inhibitors thereof, in the treatment of colon and pancreatic cancers.
Schleyer,Siew C.; Jefferson,Anne B.; Abraham,Judith A.; Kavanaugh,W. Michael, Use of NRG4, or inhibitors thereof, in the treatment of colon and pancreatic cancers.
Reinke, Petra; Volk, Hans-Dieter; Hammer, Markus; Babel, Nina; Bold, Gana, Use of a B-cell-depleting antibody for treatment of polyoma virus infections.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.