Mayo Foundation for Medical Education and Research
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Fish & Richardson P.C.
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41
초록▼
Fumaric acid or a salt thereof, such as a fumaryl halide (e.g. fumaryl chloride), which contains unsaturated carbon-carbon double bonds that can be used for in situ crosslinking, is copolymerized with poly(caprolactone)diol in the presence of an alkali metal salt. The resulting photocrosslinkable bi
Fumaric acid or a salt thereof, such as a fumaryl halide (e.g. fumaryl chloride), which contains unsaturated carbon-carbon double bonds that can be used for in situ crosslinking, is copolymerized with poly(caprolactone)diol in the presence of an alkali metal salt. The resulting photocrosslinkable biocompatible and bioresorbable poly(caprolactone fumarate) biomaterial is useful in the fabrication of injectable an in-situ hardening scaffolds for application in skeletal reconstruction.
대표청구항▼
1. A scaffold for tissue regeneration, the scaffold comprising: a biodegradable matrix comprising a copolymer including caprolactone units and fumarate;wherein the copolymer is photocrosslinkable, colorless or light colored, and clear in the melt state;wherein the matrix includes particulate or fibe
1. A scaffold for tissue regeneration, the scaffold comprising: a biodegradable matrix comprising a copolymer including caprolactone units and fumarate;wherein the copolymer is photocrosslinkable, colorless or light colored, and clear in the melt state;wherein the matrix includes particulate or fiber reinforcement materials and a bioactive agent selected from enzymes, organic catalysts, ribozvmes, organometallics, proteins, glycoproteins, peptides, polyamino acids. Antibodies, nucleic acids, steroidal molecules, antibiotics, antimycotics, cvtokines, growth factors, carbohydrates, oleophobics, lipids, extracellular matrix and/or its individual components, pharmaceuticals, therapeutics and mixtures thereof. 2. The scaffold of claim 1 wherein: reinforcement materials comprise hydroxyapatite. 3. The scaffold of claim 1 wherein: the scaffold is porous. 4. A method of making a scaffold, the method comprising: preparing a copolymer by reacting (i) a poly(ε-caprolactone)diol and (ii) fumaric acid or a salt thereof in the presence of potassium carbonate to form a repeating polymer of polycaprolactone fumarate wherein the copolymer is photocrosslinkable, colorless or light colored, and clear in the melt state; forming a biodegradable matrix of the copolymer;adding a particulate or fiber reinforcement materials to the matrix; andforming a scaffold of the matrix using a method selected from the group consisting of: extrusion, injection molding, compression molding and a solid free-form fabrication method. 5. The method of claim 4 further comprising: adding to the matrix a bioactive agent selected from enzymes, organic catalysts, ribozymes, organometallics, proteins, glycoproteins, peptides, polyamino acids, antibodies, nucleic acids, steroidal molecules, antibiotics, antimycotics, cytokines, growth factors, carbohydrates, oleophobics, lipids, extracellular matrix and/or its individual components, pharmaceuticals, therapeutics and mixtures thereof. 6. The scaffold of claim 4 wherein the solid free-form fabrication method is selected from the group consisting of stereo-lithography, selective laser sintering, ballistic particle manufacturing, fusion deposition modeling, and three dimensional printing. 7. The scaffold of claim 1, wherein the copolymer is prepared by reacting (i) a poly(ε-caprolactone)diol and (ii) fumaric acid or a salt thereof in the presence of potassium carbonate to form a repeating polymer of polycaprolactone fumarate. 8. The scaffold of claim 1, wherein the scaffold is formed using a method selected from the group consisting of: extrusion, injection molding, compression molding and a solid free-form fabrication method. 9. The scaffold of claim 1, wherein the copolymer is colorless. 10. The method of claim 4, wherein the copolymer is colorless. 11. The scaffold of claim 8, wherein the solid free-form fabrication method is selected from the group consisting of stereo-lithography, selective laser sintering, ballistic particle manufacturing, fusion deposition modeling, and three dimensional printing. 12. The scaffold of claim 7, wherein: the copolymer is prepared by reacting (i) a poly(ε-caprolactone)diol and (ii) a fumaryl halide. 13. The scaffold of claim 7, wherein: the copolymer is prepared by reacting (i) a poly(ε-caprolactone)diol and (ii) fumaryl chloride.
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이 특허에 인용된 특허 (41)
Jo, Seongbong; Mikos, Antonios G., Biocompatible macromers.
Mikos Antonios G. (Houston TX) Sarakinos Georgios (Boston MA) Vacanti Joseph P. (Winchester MA) Langer Robert S. (Newton MA) Cima Linda G. (Lexington MA), Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures.
Shulin He ; Michael J. Yaszemski ; Antonios G. Mikos, Biodegradable poly(propylene fumarate) networks cross linked with poly(propylene fumarate)-diacrylate macromers.
Han, Dong Keun; Ahn, Kwang-Duk; Kim, Jong-Man; Ju, Young Min, Biodegradable porous polymer scaffolds for tissue engineering prepared from an effervescent mixture and its preparation.
Wise Donald L. ; Gresser Joseph D. ; Trantolo Debra J. ; Hsu Y. Y., Bioerodible polymeric semi-interpenetrating network alloys and internal fixation devices made therefrom.
Yaszemski, Michael J.; Currier, Bradford L.; Lu, Lichun; Zhu, Xun; Jabbari, Esmaiel; Kempen, Diederik H. R., Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery.
Palladino Michael A. ; Lee Bruce A. ; Huse William D. ; Varner Judith A., Fivemer cyclic peptide inhibitors of diseases involving .alpha..sub.v .beta..sub.3.
Park Kinam ; Chen Jun ; Park Haesun, Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties.
Suggs Laura J. (Houston TX) Payne Richard G. (Houston TX) Yaszemski Michael J. (San Antonio TX) Mikos Antonios G. (Houston TX), Method of making poly(propylene fumarate-coethylene oxide).
Breant Patrice,FRX ; Bouilloux Alain,FRX, Mixtures of polymers including a halogen-containing polymer and compatibilized with a grafted aliphatic polyester.
Suggs Laura J. (Rice University ; 6100 Main St ; Houston TX 77005) Payne Richard G. (Rice University ; 6100 Main St ; Houston TX 77005) Yaszemski Michael J. (Lackland A.F.B. ; 59th Medical Wing/PSSB , Poly(propylene fumarate-co-ethylene oxide).
Susan J. Peter ; Laura J. Suggs ; Paul S. Engel ; Antonios G. Mikos, Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger.
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