Disclosed is a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. Further disclosed are
Disclosed is a dry composition, which upon addition of an aqueous medium forms a substantially homogenous paste suitable for use in haemostasis procedures. The paste forms spontaneously upon addition of the liquid, hence no mechanical mixing is required for said paste to form. Further disclosed are methods of preparing said dry composition, a paste made from said dry composition and use of said paste for medical and surgical purposes.
대표청구항▼
1. A method of preparing a dry composition suitable for use in haemostasis and wound healing, comprising the sequential steps of: a) providing a cross-linked biocompatible polymer in powder form, one or more polyols and an aqueous medium, wherein the one or more polyols are selected from sugar alcoh
1. A method of preparing a dry composition suitable for use in haemostasis and wound healing, comprising the sequential steps of: a) providing a cross-linked biocompatible polymer in powder form, one or more polyols and an aqueous medium, wherein the one or more polyols are selected from sugar alcohols and sugars;b) mixing the biocompatible polymer, the one or more polyols and the aqueous medium to obtain a paste; andc) freeze-drying the paste to produce a dry composition, wherein the dry composition is capable of reconstituting to form a substantially homogeneous paste without mechanical mixing, wherein the dry composition comprises from 10% w/w to 60% w/w of one or more polyols. 2. The method according to claim 1, wherein the paste prior to drying comprises from 3% w/w to 20% w/w of one or more polyols. 3. The method according to claim 1, wherein the biocompatible polymer is gelatine. 4. The method according to claim 3, wherein the gelatine is obtained from a cross-linked gelatine sponge. 5. The method according to claim 1, wherein the paste prior to freeze-drying comprises: a) from 5% w/w to 20% w/w of one or more polyols;b) from 15% w/w to 25% w/w of biocompatible polymer; andc) from 60% w/w to 80% w/w of water. 6. The method according to claim 1, wherein the dry composition comprises less than 5% w/w of water. 7. The method according to claim 1, wherein the one or more sugar alcohols is selected from glycol, glycerol, erythritol, threitol, arabitol, xylitol, ribitol, mannitol, sorbitol, dulcitol, fucitol, iditol, inositol, volemitol, isomalt, maltitol, lactitol or polyglycitol. 8. The method according to claim 1, wherein the one or more polyols is mannitol. 9. The method according to claim 8, where the dry composition comprises one or more further polyols. 10. The method according to claim 1, wherein the dry composition further comprises one or more bioactive agents that stimulate haemostasis or wound, bone, tendon and/or tissue healing. 11. The method according to claim 10, wherein the bioactive agent is thrombin. 12. The method according to claim 1, wherein the aqueous medium is selected from water, saline, a calcium chloride solution or a buffered aqueous medium. 13. The method according to claim 1, wherein the method comprises a further step of placing the dry composition into an outer packaging. 14. The method according to claim 13, wherein the outer packaging is an aluminium foil packaging. 15. The method according to claim 1, wherein the method comprises a further step of sterilising the dry composition. 16. The method according to claim 1, wherein the paste is filled into and freeze-dried within a syringe or applicator suitable for dispensing flowable haemostatic compositions. 17. The method according to claim 1, wherein the dry composition comprises from 20% w/w to 60% w/w of one or more polyols. 18. The method according to claim 1, wherein the dry composition comprises from 25% w/w to 60% w/w of one or more polyols. 19. A method for reconstituting a dry composition suitable for use in haemostasis and wound healing, comprising the sequential steps of: a) providing a cross-linked biocompatible polymer in powder form, one or more polyols and an aqueous medium, wherein the one or more polyols are selected from sugar alcohols and sugars;b) mixing the biocompatible polymer, the one or more polyols and the aqueous medium to obtain a paste;c) freeze-drying the paste to produce a dry composition, wherein the dry composition is capable of reconstituting to form a substantially homogeneous paste without mechanical mixing, wherein the dry composition comprises from 10% w/w to 60% w/w of one or more polyols; andd) adding an aqueous medium to the dry composition, thereby forming a paste without the need for mechanical mixing. 20. The method according to claim 19, wherein the dry composition is present in a container. 21. The method according to claim 20, wherein the container is a syringe.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (248)
Ashton Gregory (Markham OH CAX) Cooper John T. (West Chester OH) Hawkins Craig A. (Toronto CAX), Absorbent core having improved dry/wet integrity.
Yeung Jeffrey E. (San Jose CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA) Rhee Woonza M. (Palo Alto CA), Anti-adhesion films and compositions for medical use.
Tay Sew-Wah (Plymouth MN) Schankereli Kemal (Stillwater MN) Holman Thomas (Minneapolis MN) Mische Hans (St. Cloud MN), Apparatus and method for sealing vascular punctures.
Coelho,Philip Henry; Kingsley,Phil; Brausch,Jim; Godsey,James H.; Rock,Gail, Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby.
Sadozai, Khalid K.; Kuo, Jing-wen; Sherwood, Charles H., Bioabsorbable composites of derivatized hyaluronic acid and other biodegradable, biocompatible polymers.
Tardy Michel (Lyons FRX) Tiollier Jerome (Lyons FRX) Tayot Jean-Louis (La Tour De Salvagny FRX), Biocompatible bioresorbable and non-toxic adhesive composition for surgical use.
Epstein Gordon H. ; Lempert Todd E. ; Martin Brian B., Biological sealant mixture and system for use in percutaneous occlusion of puncture sites and tracts in the human body and method.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Biologically inert, biocompatible-polymer conjugates.
Miyata Teruo (Tokyo NJ JPX) Rubin Albert L. (Englewood NJ) Stenzel Kurt H. (Englewood NJ) Dunn Michael W. (New Rochelle NY), Collagen drug delivery device.
Chu George H. (Sunnyvale CA) Ogawa Yasushi (Pacifica CA) McPherson John M. (Hopkinton MA) Ksander George (Redwood City CA) Pratt Bruce (Union City CA) Hendricks Diana (Brea CA) McMullin Hugh (San Bru, Collagen wound healing matrices and process for their production.
Rhee Woonza M. (Palo Alto CA) Rao Prema R. (Los Gatos CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA) Harner Carol F. H. (Redwood Shores CA) Sakai Naomi (San Mateo CA) Schroeder Jacqu, Collagen-based bioadhesive compositions.
Silver Fred (Bangor PA) Sharma Vinay (Long Valley NJ) Berndt Dieter R. (Allenwood NJ) Marn Louis E. (Morris Plains NJ), Collagen-based wound dressing and method for applying same.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Pfeifer Thomas,DEX ; Weitzel Dietmar,DEX ; Kneip Wolfgang,DEX ; Vohwinkel Bernhard,DEX ; von Brand Axel,DEX, Component mixing apparatus and system including a movable cannula.
Henry Raymond L. (Grosse Pointe Woods MI), Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers an.
Palefsky Howard (Atherton CA) Pharriss Bruce B. (Palo Alto CA) Chu George (Cupertino CA), Composition of low type III content human placental collagen.
Olof Mikael Trollsas ; Donald G. Wallace ; Frank A. DeLustro, Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use.
Donald G. Wallace ; George H. Chu ; Jacqueline Anne Schroeder, Compositions and systems for forming high strength medical sealants, and associated methods of preparation and use.
Prior Jeffrey J. ; Wallace Donald G. ; Sierra David H. ; DeLustro Frank A., Compositions containing thrombin and microfibrillar collagen and methods for preparation and use thereof.
Prior Jeffrey J. ; Wallace Donald G. ; Sierra David H. ; DeLustro Frank A., Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparation and use thereof.
Yannas Ioannis V. (Newtown Center MA) Gordon Philip L. (Lexington MA) Huang Chor (Avon Lake OH) Silver Frederick H. (Danville NH) Burke John F. (Belmont MA), Crosslinked collagen-mucopolysaccharide composite materials.
Viegas Tacey X. (Ann Arbor MI) Reeve Lorraine E. (Dexter MI) Levinson Robert S. (Chesterfield MO), Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers.
Haynes Duncan H (4051 Barbarossa Ave. Miami FL 33133) Bodeker Ben H. (3925 Dunes Way Burtonsville MD 20866) Kline Mark D. (11403 Ashley Dr. Rockville MD 20852), Drug releasing surgical implant or dressing material.
Qian, Zhen; Osawa, A. Edward; Reich, Cary J.; Wallace, Donald G.; Shargill, Narinder S.; Vega, Felix, Dry hemostatic compositions and methods for their preparation.
Narotam Pradeep K.,CAX ; van Dellen James R.,ZAX ; O'Fee Robert P. ; McKinney ; III George W. ; Archibald Simon J. ; O'Grady Judith, Dural/meningeal repair product using collagen matrix.
Conston Stanley R. (San Carlos CA) Dapper Gregory S. (Newark CA) Murphy Aileen L. (Menlo Park CA) Raeder-Devens Jennifer (Oakland CA) Yamamoto Ronald (San Francisco CA), Embolization plugs for blood vessels.
Illum Lisbeth (Nottingham GBX), Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving mater.
Yves Delmotte BE; Arnold Bilstad ; David Amrani ; James DiOrio ; Atif M. Yardimci ; David W. Pennington ; James S. Slepicka ; Cristina Stadler, Fibrin delivery device and method for forming fibrin on a surface.
Wallace, Donald G.; Reich, Cary J.; Shargill, Narinder S.; Vega, Felix; Osawa, A. Edward; Qian-Wallis, Zhen, Fragmented polymeric compositions and methods for their use.
Wallace, Donald G.; Reich, Cary J.; Shargill, Narinder S.; Vega, Felix; Osawa, A. Edward; Qian-Wallis, Zhen, Fragmented polymeric compositions and methods for their use.
Hashimoto, Masamichi; Umeda, Toshihiko; Arai, Kazuhiko; Miyata, Yoshiaki; Yamamoto, Osamu; Himeda, Yasukazu, Hyaluronic acid gel composition, process for producing the same, and medical material containing the same.
Yoshiaki Miyata JP; Akio Okamoto JP; Masatoshi Kawata JP; Kazuhiro Oshima JP; Masamichi Hashimoto JP; Kazuhiko Arai JP; Tomio Sawada JP, Hyaluronic acid gel, a method of its production and medical material containing it.
Murray Douglas G. (Willowdale CAX) Smith Dennis C. (Toronto CAX) Guillet James E. (Don Mills CAX), Hydrogel-forming wound dressing or skin coating material.
Wallace Donald G. (Menlo Park CA) McMullin Hugh (Pacifica CA) Chu George (Cupertino CA), Injectable ceramic compositions and methods for their preparation and use.
Wallace Donald G. (Menlo Park) McMullin Hugh (Pacifica) Chu George (Cupertino CA), Injectable ceramic compositions and methods for their preparation and use.
Oppenheim ; Richard Charles ; Marty ; Jennifer Joy ; Speiser ; Peter, Injectable compositions, nanoparticles useful therein, and process of manufacturing same.
Wallace Donald G. (Menlo Park CA) Reihanian Hertsel (San Francisco CA) Pharriss Bruce B. (Palo Alto CA) Braun William G. (Los Altos CA), Injectable implant composition having improved intrudability.
Rhee Woonza M. ; Berg Richard A. ; Chu George H. ; DeLustro Frank A. ; Jolivette Dan M. ; McCullough Kimberly A., Injectable or implantable biomaterials for filling or blocking lumens and voids of the body.
Etienne Schacht BE; An Van Den Bulcke BE; Bernard Delaey BE; Jean-Pierre Draye BE, Medicaments based on polymers composed of methacrylamide-modified gelatin.
Wahlig Helmut (Darmstadt DEX) Dingeldain Elvira (Dreieich DEX) Braun Dietrich (Darmstadt-Arheilgen DEX), Medicinally useful, shaped mass of collagen resorbable in the body.
Wahlig Helmut (Darmstadt DEX) Dingeldein Elvira (Dreieich DEX) Braun Dietrich (Darmstadt DEX), Medicinally useful, shaped mass of collagen resorbable in the body.
Goldberg Eugene P. (Gainesville FL) Yaacobi Yoseph (Gainesville FL), Method and composition for preventing surgical adhesions using a dilute solution of polymer.
Philip Henry Coelho ; Phil Kingsley ; Jim Brausch ; James H. Godsey ; Gail Rock CA; Trista K. Madsen ; Sona B. Frausto, Method for preparing thrombin for use in a biological glue.
Eibl Johann (Vienna ATX) Schwarz Otto (Vienna ATX) Elsinger Fritz (Vienna ATX) Wber Gnter (Oberwaltersdorf ATX) Philapitsch Anton (Ebenfurt ATX) Linnau Yendra (Vienna ATX) Dorner Friedrich (Vienna AT, Method of inactivating reproducible filterable pathogens in blood products as well as a method of producing blood produc.
Harvey Michael A. ; Kremer Richard D. ; Burghoff Robert L. ; King Thomas H., Methods and devices for collecting and storing clinical samples for genetic analysis.
Sawyer Philip N. (Brooklyn NY) Sawyer Philip M. (Menlo Park CA) Reich Cary J. (Laguna Hills CA), Methods for sealing of staples and other fasteners in tissue.
Song Suk-Zu (Moorpark CA) Morawiecki Andrew (Camarillo CA) Pierce Glenn F. (Thousand Oaks CA) Pitt Colin G. (Westlake Village CA), Multi-layered collagen film compositions for delivery of proteins and methods of using same.
Saferstein Lowell (Edison NJ) Wolf Stephen (Neshanic Station NJ) Kamp Lola (Highland Park NJ) Linsky Cary (East Brunswick NJ) Wiseman David (Highland Park NJ), Process for preparing a neutralized oxidized cellulose product and its method of use.
Boctor Amal (Long Valley NJ) Mehta Surendra (Randolph NJ) Radebaugh Galen (Chester NJ), Process for purified thromboplastin for ultra-pure thrombin preparation.
Pendharkar, Sanyog M.; Gorman, Anne J.; Looney, Dwayne. Lee; Zhang, Guanghui; Rivera, Ada, Process of making flowable hemostatic compositions and devices containing such compositions.
Pendharkar, Sanyog M.; Gorman, Anne J.; Zhang, Guanghui; Rivera, Ada; Looney, Dwayne Lee; Craven, Thomas Lee, Process of making flowable hemostatic compositions and devices containing such compositions.
Pendharkar, Sanyog M.; Gorman, Anne J.; Zhang, Guanghui; Rivera, Ada; Looney, Dwayne Lee; Craven, Thomas Lee, Process of making flowable hemostatic compositions and devices containing such compositions.
Sharma Vinay K. (12 Walnut Dr. Long Valley NJ 07853), Process of preparing microparticulate collagen, collagen-based products thereby and method of applying same.
Silbering Steven B. (Forest Hills NY) Blythe ; Jr. Rowland P. (Washington MI) Nesbitt ; Jr. Russell U. (Somerville NJ) Fawzi Mahdi B. (Flanders NJ), Purified thrombin preparations.
Wallace Donald G. ; Cruise Gregory M. ; Rhee Woonza M. ; Schroeder Jacqueline Anne ; Coker ; III George T. ; Maroney Marcee M., Rapid gelling biocompatible polymer composition.
Nabai Hossein (14555 Levan Rd. ; Suite 410 Livonia MI 48154) Rahbari Homayoon (1314 N. Macomb St. ; P.O. Box 360 Monroe MI 48161), Skin biopsy plug and method.
Perbellini Alberto (Padua ITX) Toffano Gino (Montegrotto Terme ITX) Romeo Aurelio (Rome ITX), Spongy material consisting essentially of hyaluronic acid or its derivatives, and its use in microsurgery.
Trevino Leo A. ; Schutt Ernest George ; Klein David H. ; Tarara Thomas E. ; Weers Jeffry G. ; Kabalnov Alexey, Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement.
Kensey Kenneth (Chester Springs PA) Nash John E. (Downington PA) Evans Douglas (Devon PA), System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating.
Bass Lawrence S. (Little Neck NY) Libutti Steven K. (Fort Lee NJ) Eaton Alexander M. (Durham NC), Tissue bonding and sealing composition and method of using the same.
Bass Lawrence S. (Little Neck NY) Libutti Steven K. (Lido Beach NY) Eaton Alexander M. (New York NY), Tissue bonding and sealing composition and method of using the same.
Hermes Matthew E. (Easton CT) Muth Ross R. (Brookfield CT) Gustafson Darel L. (Shelton CT), Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin.
Tsouderos Yannis,FRX ; Deloffre Pascale,FRX ; Wierzbicki Michel,FRX, Use of strontium salts and pharmaceutical compositions thereof for the treatment of arthrosis.
Kuo Jing-Wen (Stoneham MA) Swann David A. (Lexington MA) Prestwich Glenn D. (Harbor NY), Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use.
Dean ; Jr. Robert C. (Norwich VT) Silver Frederick H. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Phillips Philip G. (Norwich VT) Runstadler ; Jr. Peter W. (Hanover NH), Weighted collagen microsponge for immobilizing bioactive material.
Dean ; Jr. Robert C. (Norwich VT) Silver Frederick H. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Phillips Philip G. (Norwich VT) Runstadler ; Jr. Peter W. (Hanover NH), Weighted collagen microsponge for immobilizing bioactive material.
Dean ; Jr. Robert C. (Norwich VT) Silver Frederick H. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Phillips Philip G. (Norwich VT) Runstadler ; Jr. Peter W. (Hanover NH) Maffia Gennaro J. (Leba, Weighted collagen microsponge for immobilizing bioactive materials.
Weldon Thomas D. (P.O. Box 5149 Aquadilla PR 00605) Larsen Charles E. (P.O. Box 5149 Aquadilla PR 00605), Wound treating device using an inflatable membrane and method for treating wounds.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.