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An osteoinductive bone graft substitute including an osteoinductive calcium phosphate component retained within a collagen scaffold, wherein the collagen scaffold is formulated to maintain the osteoinductivity of the calcium phosphate component while also exhibiting the following characteristics (1)

An osteoinductive bone graft substitute including an osteoinductive calcium phosphate component retained within a collagen scaffold, wherein the collagen scaffold is formulated to maintain the osteoinductivity of the calcium phosphate component while also exhibiting the following characteristics (1) ability to absorb bone marrow and/or other physiologic liquids, (2) compression resistance; (3) moldability; (4) retaining the calcium phosphate component during and after manipulation of the collagen scaffold and (5) fibrous collagen matrix that retains but does not occlude the osteoinductive calcium phosphate component.

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1. A method of making an osteoinductive bone graft substitute, comprising: mixing a first soluble collagen solution having a first concentration with osteoinductive calcium phosphate granules to create a slurry;blending the slurry with a second soluble collagen solution having a second concentration

1. A method of making an osteoinductive bone graft substitute, comprising: mixing a first soluble collagen solution having a first concentration with osteoinductive calcium phosphate granules to create a slurry;blending the slurry with a second soluble collagen solution having a second concentration which is greater than the first concentration to create a mixture having a final collagen concentration of 65 mg/g;pouring the mixture into a mold; andlyophilizing the mixture. 2. The method of making an osteoinductive bone graft of claim 1, wherein the first collagen solution has a concentration of 12.5 mg/g. 3. The method of making an osteoinductive bone graft of claim 1, wherein the second collagen solution has a concentration of 100 mg/g. 4. The method of making an osteoinductive bone graft of claim 1, wherein the osteoinductive calcium phosphate comprises greater than 90% β-TCP and less than 10% hydroxyapatite. 5. The method of making an osteoinductive bone graft of claim 1, wherein the osteoinductive calcium phosphate comprises 100% β-TCP.